10 Heart Disease Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Heart Disease Studies in Birmingham

NCT07000357Recruiting

A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event

The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in ...

Birmingham, ALPHASE315,100 participantsAstraZeneca

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NCT07181109Recruiting

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

The purpose of this study is to evaluate whether zilebesiran versus placebo reduces the risk of cardiovascular (CV) death, nonfatal myocardial infarction (MI), nonfatal stroke, or heart failure (HF) e...

Birmingham, ALPHASE311,000 participantsAlnylam Pharmaceuticals

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NCT07136012Recruiting

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization...

Birmingham, ALPHASE311,000 participantsAmgen

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NCT06909565Recruiting

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

V-INTERVENTION will evaluate the effectiveness of inclisiran in preventing major cardiovascular and limb events in patients receiving percutaneous coronary or peripheral arterial revascularization. In...

Birmingham, ALPHASE46,000 participantsDuke University

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NCT06535854Recruiting

Prevail Global Study

The purpose of the study is to evaluate the clinical safety and efficacy of the Prevail DCB....

Birmingham, ALNA1,205 participantsMedtronic Vascular

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NCT05618353Recruiting

The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial

Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death. Patients with heart disease undergoing major surgery are...

Birmingham, ALPHASE4700 participantsVA Office of Research and Development

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NCT06875973Recruiting

Pelacarsen Roll-over Extension Program

This non-randomized, rollover extension study will provide post-trial access to pelacarsen (TQJ230) to participants who have successfully completed either of the double-blind parent studies (CTQJ230A1...

Birmingham, ALPHASE3599 participantsNovartis Pharmaceuticals

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NCT06153459Recruiting

Cord Clamping Among Neonates With Congenital Heart Disease

The goal of this clinical trial is to compare 2 different timepoints for clamping the umbilical cord at birth for term-born infants with a prenatal diagnosis of congenital heart disease (CHD). The mai...

Birmingham, ALNA500 participantsCarl Backes, MD

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NCT06813911Recruiting

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

The purpose of the study CTQJ230A12304, is to evaluate the efficacy, safety, and tolerability of pelacarsen (TQJ230) compared to placebo in participants with ASCVD who have elevated lipoprotein(a) (Lp...

Birmingham, ALPHASE3340 participantsNovartis Pharmaceuticals

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NCT05216042Recruiting

GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study

Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of ...

Birmingham, ALNA200 participantsUniversity of Alabama at Birmingham

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About Heart Disease Clinical Trials in Birmingham

Heart disease is the leading cause of death worldwide, encompassing conditions that affect the heart and blood vessels. Coronary artery disease, the most common type, occurs when arteries supplying the heart become narrowed or blocked. Risk factors include high blood pressure, high cholesterol, diabetes, and smoking.

There are currently 10 heart disease clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 46,644 participants. Research is being sponsored by AstraZeneca, Alnylam Pharmaceuticals, Amgen and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Disease Clinical Trials in Birmingham — FAQ

Are there heart disease clinical trials in Birmingham?

Yes, there are 10 heart disease clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What heart disease treatments are being tested?

The 10 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for heart disease.

Data updated July 17, 2026 from ClinicalTrials.gov