45 Myalgic Encephalomyelitis Clinical Trials in Birmingham, AL (2026)

Q: How do I join a clinical trial in Birmingham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you.

Recruiting Myalgic Encephalomyelitis Studies in Birmingham

NCT07177352Recruiting

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

This study is a pre-screening process used to assess participants' potential eligibility for Roche interventional Alzheimer's disease studies....

Birmingham, ALPHASE380,000 participantsHoffmann-La Roche

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NCT04262206Recruiting

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

PREVENTABLE is a multi-center, randomized, parallel group, placebo-controlled superiority study. Participants will be randomized 1:1 to atorvastatin 40 mg or placebo. This large study conducted in com...

Birmingham, ALPHASE420,000 participantsDuke University

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NCT05685745Recruiting

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

The goal of the Tiny Baby Collaborative Multicenter Inventory of Neonatal-Perinatal Interventions (MINI) minimum dataset is to serve as a registry detailing the outcomes and practices for all deliveri...

Birmingham, AL5,000 participantsThe University of Texas Health Science Center, Houston

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NCT07667803Recruiting

A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM

This master study protocol, Study D7260C00015, covers 2 independent, pivotal studies, Study 1 and Study 2. Each study is a global, randomized, double-blind, parallel-group, multicenter, Phase III stud...

Birmingham, ALPHASE34,500 participantsAstraZeneca

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NCT05918861Recruiting

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

This is a placebo-controlled, randomized, double-blind, parallel group, phase 3 multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile. Subjects will prov...

Birmingham, ALPHASE32,000 participantsDalCor Pharmaceuticals

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NCT01429389Recruiting

Specimen Collection from Pregnant Women At Increased Risk for Fetal Aneuploidy

The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21....

Birmingham, AL2,000 participantsSequenom, Inc.

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NCT03538665Recruiting

The DETECT Study: Discovery and Evaluation of Testing for Endometrial and Ovarian Cancer in Tampons

BACKGROUND: Endometrial cancer is a common and deadly cancer for women. It is getting more common and deadly because risk factors like age and obesity are increasing. Also, this cancer is becoming mo...

Birmingham, AL1,700 participantsUniversity of Alabama at Birmingham

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NCT07406360Recruiting

A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Administered as Intramuscular Injection to Healthy Children 15 Months to 6 Years of Age

This study is evaluating the immunogenicity and safety of intramuscular administration of the investigational MMRVNS vaccine compared to intramuscular administration of the MMRV (Merck's measles, mump...

Birmingham, ALPHASE31,209 participantsGlaxoSmithKline

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NCT07169578Recruiting

A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

The purpose of this study is to assess the efficacy and safety of trontinemab in participants with early symptomatic Alzheimer's disease (AD) (mild cognitive impairment \[MCI\] to mild dementia due to...

Birmingham, ALPHASE3800 participantsHoffmann-La Roche

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NCT05727904Recruiting

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared with pembrolizumab al...

Birmingham, ALPHASE3670 participantsIovance Biotherapeutics, Inc.

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NCT07146516Recruiting

Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults. Resear...

Birmingham, ALNA500 participantsHelen Keller Eye Research Foundation

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NCT05256225Recruiting

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

This phase III trial tests whether adding trastuzumab and hyaluronidase-oysk (Herceptin Hylecta \[TM\]) or pertuzumab, trastuzumab and hyaluronidase-zzxf (Phesgo \[TM\]) to the usual chemotherapy (pac...

Birmingham, ALPHASE3360 participantsNational Cancer Institute (NCI)

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NCT05702645Recruiting

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment...

Birmingham, AL330 participantsChildren's Oncology Group

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NCT06679855Recruiting

Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

The goal of this Phase 3, randomized, masked clinical trial is to is to find out whether milrinone, when given to infants after PDA closure, will help the heart work better by supplying oxygen to the ...

Birmingham, ALPHASE3316 participantsNICHD Neonatal Research Network

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NCT07335497Recruiting

CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors

The purpose of this study is to determine the safety and tolerability of monotherapy CR-001 and identify the maximum tolerated dose (MTD), and/or optimal biologic dose and Recommended Phase 2 Dose(s) ...

Birmingham, ALPHASE1290 participantsCrescent Biopharma, Inc.

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NCT06647498Recruiting

A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individu...

Birmingham, ALPHASE2280 participantsWashington University School of Medicine

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NCT05552157Recruiting

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation

The purpose is to evaluate the biomarker effect, safety, and tolerability of investigational study drugs in participants who are known to have an Alzheimer's disease (AD)-causing mutation. Stage 1 wil...

Birmingham, ALPHASE2280 participantsWashington University School of Medicine

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NCT07198074Recruiting

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

This phase III trial compares the effect of bevacizumab in combination with carboplatin, paclitaxel and pembrolizumab to the usual treatments of carboplatin and paclitaxel with or without pembrolizuma...

Birmingham, ALPHASE3255 participantsNational Cancer Institute (NCI)

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NCT06734351Recruiting

A Study to Assess Safety and Effectiveness of Injections of NOA VOLUME Injectable Gel in Adult Participants Compared to JUVÉDERM VOLUMA XC for Change of Mid-Face Volume

Facial fullness is often regarded as a characteristic feature of a youthful face. Chronic reduction of collagen, elastin, and glycosaminoglycans contribute to the facial volume loss that characterizes...

Birmingham, ALPHASE3231 participantsAbbVie

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NCT05382338Recruiting

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

This phase III trial tests two hypotheses in patients with low-risk and average-risk medulloblastoma. Medulloblastoma is a type of cancer that occurs in the back of the brain. The term, risk, refers t...

Birmingham, ALPHASE3225 participantsChildren's Oncology Group

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NCT06099769Recruiting

A Study of Enzalutamide, Enzalutamide in Combination With Mifepristone, or Chemotherapy in People With Metastatic Breast Cancer

The researchers are doing this study to find out if the study drug, enzalutamide, alone or combined with the study drug, mifepristone, is effective in treating advanced or metastatic androgen receptor...

Birmingham, ALPHASE2201 participantsMemorial Sloan Kettering Cancer Center

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NCT06701682Recruiting

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute...

Birmingham, ALPHASE2200 participantsPPD Development, LP

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NCT07553637Recruiting

ALTO-207 in Adults With Treatment-resistant Depression (TRD)

The purpose of this trial is to measure depressive symptoms following treatment with ALTO-207 compared with placebo in participants with TRD....

Birmingham, ALPHASE2178 participantsAlto Neuroscience

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NCT03180268Recruiting

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery

This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by sur...

Birmingham, ALPHASE3163 participantsNRG Oncology

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NCT07281079Recruiting

A Study of NNZ-2591 in Pediatric Participants With Phelan-McDermid Syndrome

This Phase 3, randomized, double-blind, parallel-group (2-arm), placebo-controlled, multicenter study will evaluate the efficacy and safety of NNZ-2591 compared to placebo in pediatric participants wi...

Birmingham, ALPHASE3160 participantsNeuren Pharmaceuticals Limited

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NCT04462770Recruiting

A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome

This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole hydrochloride (EPX-100) as adjunctive therapy in children a...

Birmingham, ALPHASE3150 participantsEpygenix

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NCT05606432Recruiting

Cardiometabolic Health Intervention Using Movement-to-Music Exercise

The study aims to test the benefits of a 24-week, cardio-emphasized Movement-to-Music exercise program for reversing cardiometabolic health risk factors compared to asynchronous, standard exercise pro...

Birmingham, ALNA132 participantsUniversity of Alabama at Birmingham

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NCT02523014Recruiting

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting wor...

Birmingham, ALPHASE2124 participantsAlliance for Clinical Trials in Oncology

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NCT04511013Recruiting

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

This phase II trial compares the effect of encorafenib, binimetinib, and nivolumab versus ipilimumab and nivolumab in treating patients with BRAF- V600 mutant melanoma that has spread to the brain (br...

Birmingham, ALPHASE2112 participantsSWOG Cancer Research Network

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NCT07002034Recruiting

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adj...

Birmingham, ALPHASE2100 participantsReunion Neuroscience Inc

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NCT06423430Recruiting

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjuncti...

Birmingham, ALNA100 participantsAbbott Medical Devices

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NCT03739814Recruiting

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

This phase II trial studies how well inotuzumab ozogamicin and blinatumomab with or without ponatinib work in treating patients with CD22-positive B-lineage acute lymphoblastic leukemia that is newly ...

Birmingham, ALPHASE284 participantsNational Cancer Institute (NCI)

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NCT05112601Recruiting

Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma

This phase II trial tests whether the combination of nivolumab and ipilimumab is better than nivolumab alone to shrink tumors in patients with deficient mismatch repair system (dMMR) endometrial carci...

Birmingham, ALPHASE281 participantsNational Cancer Institute (NCI)

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NCT03094026Recruiting

Cognitive Training Intervention and Attitudes Towards Genetics

A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic cell transplantation (HCT) survivors using the cognitive training...

Birmingham, ALNA60 participantsUniversity of Alabama at Birmingham

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NCT07211685Recruiting

A Study to Learn About How Well BAY 3401016 Works in Adults With Alport Syndrome

Alport syndrome (AS) is a rare genetic condition that causes kidney disease, hearing loss, and eye abnormalities that occur due to changes in specific genes (COL4A3, COL4A4, and COL4A5). These genes h...

Birmingham, ALPHASE260 participantsBayer

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NCT03949855Recruiting

Belimumab With Rituximab for Primary Membranous Nephropathy

The primary objective of this study is to evaluate the effectiveness of belimumab and intravenous rituximab co-administration at inducing a complete or partial remission (CR or PR) compared to rituxim...

Birmingham, ALPHASE258 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT07179406Recruiting

The Effect of Spinal Cord Stimulators on Restless Leg Syndrome

This study aims to evaluate neurophysiological responses and symptom changes in individuals with Restless Legs Syndrome (RLS) and/or chronic pain. Participants will undergo standard clinical assessmen...

Birmingham, ALNA50 participantsUniversity of Alabama at Birmingham

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NCT07224529Recruiting

Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction

This research study evaluates a prescription eye drop called Vevye® (cyclosporine 0.1%) for adults who have meibomian gland dysfunction (MGD), a common eye condition that can cause dry, irritated, or ...

Birmingham, ALPHASE448 participantsUniversity of Alabama at Birmingham

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NCT07199465Recruiting

A Clinical Study of Letermovir (MK-8228) in Children and Adolescents Who Receive a Kidney Transplant (KT) (MK-8228-077)

Researchers are looking for a way to prevent cytomegalovirus (CMV) in children and adolescents who receive a kidney transplant (KT) and weigh less than 40 kilograms (88.2 pounds). The goals of the stu...

Birmingham, ALPHASE140 participantsMerck Sharp & Dohme LLC

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NCT07288112Recruiting

DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma

The goal of this clinical trial is to learn if DOC1021 + pIFN will be safe and will lead to tumor responses in patients with refractory melanoma. DOC1021 is a dendritic cell immunotherapy derived from...

Birmingham, ALPHASE135 participantsDiakonos Oncology Corporation

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NCT07523113Recruiting

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

The purpose of this study is to compare two approaches to cognitive rehabilitation in adults with post-viral cognitive syndrome, which resulted in brain fog. All participants will be screened for elig...

Birmingham, ALNA30 participantsUniversity of Alabama at Birmingham

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NCT05084430Recruiting

Study of Pembrolizumab and M032 (NSC 733972)

This Phase I (Cohort I and Cohort II) and Phase II trial is designed to confirm the safety and tolerability of Pembrolizumab when given in conjunction with M032, an Oncolytic Herpes Simplex Virus (oHS...

Birmingham, ALPHASE128 participantsUniversity of Alabama at Birmingham

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NCT06701812Recruiting

Digoxin Medulloblastoma Study

The purpose of this study is to evaluate the efficacy of digoxin in treating relapsed non-SHH, non-WNT medulloblastoma in pediatric and young adult patients....

Birmingham, ALPHASE223 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT06771206Recruiting

Evaluation of Accuracy of the Owlet OSS 3.0 Sensor in the Neonatal Population

The sponsor of this study, Owlet Baby Care, Inc., is comparing the accuracy of their pulse oximeter Sensor with the measurements of oxygen levels in newborns who are already being monitored with arter...

Birmingham, ALNA20 participantsOwlet Baby Care, Inc.

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NCT07194044Recruiting

Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes

This single arm study is designed to demonstrate the feasibility of a radically different approach for an exceptionally high-risk subset of MES with widely metastatic disease (WMES). We incorporate th...

Birmingham, ALPHASE115 participantsH. Lee Moffitt Cancer Center and Research Institute

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About Myalgic Encephalomyelitis Clinical Trials in Birmingham

Myalgic encephalomyelitis (ME/CFS) is a complex, chronic illness characterized by profound fatigue, post-exertional malaise, cognitive impairment, and sleep dysfunction. It affects millions worldwide and has no definitive diagnostic test or cure. Research is exploring immune, metabolic, and neurological mechanisms.

There are currently 45 myalgic encephalomyelitis clinical trials recruiting participants in Birmingham, AL. These studies are seeking a combined 123,198 participants. Research is being sponsored by Hoffmann-La Roche, Duke University, The University of Texas Health Science Center, Houston and 29 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Myalgic Encephalomyelitis Clinical Trials in Birmingham — FAQ

Are there myalgic encephalomyelitis clinical trials in Birmingham?

Yes, there are 45 myalgic encephalomyelitis clinical trials currently recruiting in Birmingham, AL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Birmingham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Birmingham research site will contact you about next steps.

Are clinical trials in Birmingham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Birmingham studies also compensate for your time and travel.

What myalgic encephalomyelitis treatments are being tested?

The 45 active trials in Birmingham are testing new therapies including novel drugs, biologics, and treatment approaches for myalgic encephalomyelitis.

Data updated August 29, 2026 from ClinicalTrials.gov