12 Cardiomyopathy Clinical Trials in Boston, MA (2026)

Q: How do I join a clinical trial in Boston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you.

Recruiting Cardiomyopathy Studies in Boston

NCT07358078Recruiting

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

The purpose of this study is to: * Describe the clinical characteristics of adult patients with transthyretin-mediated amyloidosis with cardiomyopathy (ATTR-CM) treated with vutrisiran in routine cli...

Boston, MA2,000 participantsAlnylam Pharmaceuticals

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NCT07210723Recruiting

A Study of the Efficacy and Safety of Danicamtiv in Participants With Symptomatic Genetic and Familial Dilated Cardiomyopathy

The Sponsor is studying an investigational medication called danicamtiv to determine if it can help people with genetic and familial dilated cardiomyopathy (DCM). Investigational means that the safety...

Boston, MA332 participantsKardigan, Inc.

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NCT07608354Recruiting

A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

The purpose of this randomised, double-blind, placebo-controlled, multicenter study is to evaluate the efficacy and safety of concomitant use of eplontersen and ALXN2220 compared with eplontersen and ...

Boston, MA326 participantsAstraZeneca

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NCT07054073Recruiting

HCMR Re-Imaging Study

This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM). HC...

Boston, MA314 participantsChristopher Kramer

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NCT06311708Recruiting

Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

This is a multicenter, non-interventional study to observe the natural progression of the disease and to study the prevalence of pre-existing antibodies to AAV9 used for gene therapy in a population o...

Boston, MA200 participantsTenaya Therapeutics

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NCT07023614Recruiting

A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy

FORTITUDE-HCM is a global, multicenter, double-blind, parallel-group, placebo-controlled Phase 2b study that will assess the efficacy and safety of ninerafaxstat compared to placebo on top of Standard...

Boston, MA165 participantsImbria Pharmaceuticals, Inc.

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NCT06551129Recruiting

Real-world Patient Reported Outcomes Among Patients Treated With Camzyos

This real-world study will assess changes in health status among participants with symptomatic obstructive hypertrophic cardiomyopathy who are treated with mavacamten in the real world....

Boston, MA118 participantsBristol-Myers Squibb

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NCT05797857Recruiting

Exercise Training in Transthyretin Cardiac Amyloidosis

Transthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training program to improve functional capacity in patie...

Boston, MA40 participantsBrigham and Women's Hospital

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NCT05836259Recruiting

Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

This is a first-in-human, non-randomized, open-label study designed to evaluate the safety, tolerability, and pharmacodynamics (PD) of TN-201 in adult patients with symptomatic hypertrophic cardiomyop...

Boston, MA30 participantsTenaya Therapeutics

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NCT07606274Recruiting

A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)

This study is designed to evaluate the safety and tolerability of NVC-001 in adults with LMNA-related dilated cardiomyopathy (LMNA-DCM). The study will also assess exploratory measures of efficacy....

Boston, MA21 participantsNuevocor Pte. Ltd.

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NCT06228924Recruiting

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

This first-in-human study is designed to evaluate the safety, and preliminary efficacy (PD) of TN-401 gene therapy in adult patients with symptomatic PKP2 mutation-associated ARVC....

Boston, MA15 participantsTenaya Therapeutics

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NCT07218887Recruiting

ALXN2350 in Adult Participants With BAG3-Associated Dilated Cardiomyopathy

This Phase 1/2 study is an open-label, dose finding and dose expansion study investigating the safety, tolerability, and efficacy of a single IV infusion of ALXN2350 in adult participants with BAG3 as...

Boston, MA6 participantsAlexion Pharmaceuticals, Inc.

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About Cardiomyopathy Clinical Trials in Boston

Cardiomyopathy refers to diseases of the heart muscle that make it harder for the heart to pump blood. Types include dilated, hypertrophic, and restrictive cardiomyopathy. Treatment depends on the type and may include medications, devices, or heart transplant.

There are currently 12 cardiomyopathy clinical trials recruiting participants in Boston, MA. These studies are seeking a combined 3,567 participants. Research is being sponsored by Alnylam Pharmaceuticals, Kardigan, Inc., AstraZeneca and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Cardiomyopathy Clinical Trials in Boston — FAQ

Are there cardiomyopathy clinical trials in Boston?

Yes, there are 12 cardiomyopathy clinical trials currently recruiting in Boston, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Boston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Boston research site will contact you about next steps.

Are clinical trials in Boston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Boston studies also compensate for your time and travel.

What cardiomyopathy treatments are being tested?

The 12 active trials in Boston are testing new therapies including novel drugs, biologics, and treatment approaches for cardiomyopathy.

Data updated July 13, 2026 from ClinicalTrials.gov