28 Breast Cancer Clinical Trials in Chapel Hill, NC (2026)

Q: How do I join a clinical trial in Chapel Hill?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chapel Hill research site will contact you.

Recruiting Breast Cancer Studies in Chapel Hill

NCT01000883Recruiting

Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer....

Chapel Hill, NC10,000 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07214610Recruiting

Integrating Biological, Clinical, and Behavioral Factors to Improve Breast Cancer Outcomes - Carolina Breast Cancer Study

Phase 4 of the Carolina Breast Cancer Study (CBCS4) builds on prior phases that examined molecular and epidemiologic differences in breast cancer types and outcomes. Previous findings showed that cert...

Chapel Hill, NCNA3,300 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07340541Recruiting

Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

This is a multicenter, multi-arm, biomarker-stratified trial designed to evaluate biomarker-directed therapies in patients with estrogen receptor-positive/hormone receptor-negative (ER+/HR-) and tripl...

Chapel Hill, NCPHASE2700 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT03769415Recruiting

Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

The HARMONY trial is an interventional trial enrolling metastatic breast cancer (MBC). Current treatment of breast cancer uses clinical subtype information (e.g. hormone receptor-positive (HR+)) to he...

Chapel Hill, NCNA500 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT06533826Recruiting

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

The purpose of this study is to test the safety and effectiveness of the sequence of two investigational drugs (trastuzumab deruxtecan followed by datopotamab deruxtecan, or datopotamab deruxtecan fol...

Chapel Hill, NCPHASE2357 participantsAna C Garrido-Castro, MD

View Study Details

NCT06878547Recruiting

VisR Ultrasound for Noninvasively Interrogating Stromal Collagen Organization in Women as a Breast Cancer Biomarker: Evaluation of Anisotropy in Cancer Patients

Purpose: This study will evaluate how measurements of tissue stiffness, viscosity, and anisotropy using non-invasive ultrasound imaging correlate with breast tumor malignancy and response to chemother...

Chapel Hill, NC250 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07389967Recruiting

Nutrition Awareness Among Women With Non-Metastatic Breast Cancer

This study explores perspectives of women with non-metastatic breast cancer regarding their willingness and ability to make dietary changes pertaining to foods/food products that may pose a risk to th...

Chapel Hill, NCNA200 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT06610539Recruiting

PAS 1ml Magtrace® for Sentinel Lymph Node Biopsy in Breast Cancer Patients

The purpose of this study is to provide prospective evidence in the US population of the frequency of skin discoloration and Sentinel Lymph Node detection rate in patients who have recevied Magtrace f...

Chapel Hill, NC184 participantsEndomagnetics Ltd.

View Study Details

NCT06855654Recruiting

Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

This pilot interventional study evaluates the change from baseline to post-intervention in resilience and other patient-reported outcomes for individuals with a recent diagnosis of metastatic breast c...

Chapel Hill, NCNA120 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT04468061Recruiting

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

This research study involves testing the safety and efficacy of an investigational intervention for patients with triple-negative breast cancer (TNBC) that has spread, or metastasized, to other parts ...

Chapel Hill, NCPHASE2110 participantsDana-Farber Cancer Institute

View Study Details

NCT07025785Recruiting

Molecular Residual Disease Assessment in a Representative Diverse Population of Patients With Early-stage Breast Cancer

The purpose of this study is to determine how circulating tumor DNA (ctDNA), a sign of minimal residual disease (MRD), is detectable after surgery in patients with early HR+/HER2- breast cancer that h...

Chapel Hill, NCNA100 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT06902311Recruiting

Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

This study evaluates the rates of radiation-specific toxicity, quality of life, and oncologic outcomes for early-stage breast cancer and ductal carcinoma in situ treated with 5-fraction whole breast i...

Chapel Hill, NCPHASE290 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT05472792Recruiting

Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy

The aim of this prospective study is to investigate quality of life and oncologic outcomes in low-risk elderly breast cancer patients randomized to adjuvant therapy with accelerated partial breast irr...

Chapel Hill, NCPHASE290 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT06727773Recruiting

Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer

This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise p...

Chapel Hill, NCPHASE290 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT06789653Recruiting

A Novel Approach Utilizing Organ Specific Age Proteomics

This study compares changes in P16INK4A expression and plasma proteomic signatures of specific organ age pre- and post-chemotherapy in women treated with adjuvant chemotherapy for early-stage breast c...

Chapel Hill, NC80 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07069595Recruiting

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

This is a Phase II, interventional, prospective, single-arm, multi-center study that will enroll patients with stage II/III triple negative breast cancer (TNBC) who have residual cancer burden (RCB) I...

Chapel Hill, NCPHASE278 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT05557877Recruiting

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

This phase II trial tests whether low-dose aspirin can affect markers of inflammation in postpartum (after childbirth) women planning to have a breast biopsy. Chronic inflammation may increase the ris...

Chapel Hill, NCPHASE260 participantsMayo Clinic

View Study Details

NCT05501704Recruiting

ETHAN - ET for Male BC

This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male...

Chapel Hill, NCPHASE260 participantsJose Pablo Leone

View Study Details

NCT06817226Recruiting

BREAST Choice Decision Tool R21 - AIM2

Breast reconstruction is a critical component of breast cancer treatment because it restores quality of life and body image after mastectomy. However, Spanish-speaking Latina women are significantly l...

Chapel Hill, NCNA50 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07313306Recruiting

Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise

This study will examine unmet exercise needs among patients with metastatic breast cancer (MBC) at UNC and assess whether participation in Get Real and Heel (GRH) can increase physical activity. The p...

Chapel Hill, NCNA50 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT06347068Recruiting

Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells

This phase 1, single-center, open-label study explores the safety of escalating doses of chimeric antigen receptor T cells (CAR-T) cells in subjects with relapsed/refractory triple-negative breast can...

Chapel Hill, NCPHASE142 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07225114Recruiting

Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging

This is a 4-arm, single-center study involving 40 participants. Ten healthy volunteers will be enrolled for system imaging optimization, and thirty (30) patients with previously identified lesions in ...

Chapel Hill, NCPHASE240 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07276880Recruiting

Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer

This is a prospective radiation dose-finding, phase 2 expansion study of the Triple Negative (TN) cohort of the multicenter randomized study P-RAD (A Randomized Study of Preoperative Chemotherapy, Pem...

Chapel Hill, NCPHASE232 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT05029999Recruiting

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

This research study is being done to find out if the immunotherapy drugs called CDX-301 and CDX-1140 in combination with the standard chemotherapy treatment pegylated liposomal doxorubicin (PLD, Doxil...

Chapel Hill, NCPHASE130 participantsUniversity of Texas Southwestern Medical Center

View Study Details

NCT05974150Recruiting

Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring

The goal of this study is to create a data set to add to Carevive's registry from real world clinical and patient reported data collected using an electronic care planning system (CPS) with remote sym...

Chapel Hill, NC25 participantsCarevive Systems, Inc.

View Study Details

NCT05754749Recruiting

Comparison of CE-DBT and MRI in Patients With Known Breast Lesions

The purpose of this pilot study is to compare radiologist confidence level in evaluating patients with known breast lesions between contrast enhanced digital breast tomosynthesis (CE- DBT) and contras...

Chapel Hill, NCEARLY_PHASE120 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT07396766Recruiting

Dissemination of BREASTChoice AIM1-B

This registration covers only Aim 1b, which focuses on testing usability. The study will include 20 participants who are breast cancer patients. Participants will be observed using the tool on their m...

Chapel Hill, NCNA20 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

NCT05440929Recruiting

Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

I this qualitative study, Investigators will conduct semi-structured interviews with clinicians that are involved in the care of patients with breast cancer to evaluate the acceptability, appropriaten...

Chapel Hill, NC15 participantsUNC Lineberger Comprehensive Cancer Center

View Study Details

About Breast Cancer Clinical Trials in Chapel Hill

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 28 breast cancer clinical trials recruiting participants in Chapel Hill, NC. These studies are seeking a combined 16,693 participants. Research is being sponsored by UNC Lineberger Comprehensive Cancer Center, Ana C Garrido-Castro, MD, Endomagnetics Ltd. and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Chapel Hill — FAQ

Are there breast cancer clinical trials in Chapel Hill?

Yes, there are 28 breast cancer clinical trials currently recruiting in Chapel Hill, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chapel Hill?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chapel Hill research site will contact you about next steps.

Are clinical trials in Chapel Hill free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chapel Hill studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 28 active trials in Chapel Hill are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated July 18, 2026 from ClinicalTrials.gov