18 Pulmonary Hypertension Clinical Trials in Chapel Hill, NC (2026)

Q: How do I join a clinical trial in Chapel Hill?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chapel Hill research site will contact you.

Recruiting Pulmonary Hypertension Studies in Chapel Hill

NCT04774159Recruiting

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular ...

Chapel Hill, NCPHASE36,150 participantsPopulation Health Research Institute

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NCT00288119Recruiting

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarc...

Chapel Hill, NC2,000 participantsCase Western Reserve University

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NCT06687603Recruiting

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test. Barrett's esophagus is a condition in which the flat pink l...

Chapel Hill, NCNA800 participantsCase Comprehensive Cancer Center

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NCT05208190Recruiting

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine ...

Chapel Hill, NCPHASE4280 participantsNew York State Psychiatric Institute

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NCT05948943Recruiting

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

The main purpose of this study in participants with PIK3CA-mutated LyM is to assess the change in radiological response and symptom severity upon treatment with alpelisib film-coated tablets (FCT) as ...

Chapel Hill, NCPHASE2232 participantsNovartis Pharmaceuticals

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NCT06777901Recruiting

Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone

The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages. The main question it aims to answer is: Is tr...

Chapel Hill, NCPHASE4224 participantsAngiodynamics, Inc.

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NCT04564989Recruiting

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating...

Chapel Hill, NC220 participantsUNC Lineberger Comprehensive Cancer Center

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NCT06238648Recruiting

Epcoritamab Compared to Observation for Treating B-cell Lymphoma Patients Not in Complete Remission After CD19-directed CAR-T Therapy

This phase II trial compares epcoritamab to standard practice (observation) for the treatment of patients with B-cell lymphomas who are not in complete remission after treatment with CD19-directed chi...

Chapel Hill, NCPHASE2120 participantsAcademic and Community Cancer Research United

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NCT05538208Recruiting

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

The study is a 1-year 2-part double-blinded placebo controlled 2-arm clinical trial. Treatment arms are (1) MMF dosed as per body-surface area (MMFBSA; 600mg/m2 body surface area per dose about every ...

Chapel Hill, NCPHASE2105 participantsChildren's Hospital Medical Center, Cincinnati

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NCT04771572Recruiting

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

This is a Phase 1, multi-center, open-label study with a dose-escalation phase (Phase 1a) and a cohort expansion phase (Phase 1b), to evaluate the safety, tolerability, and PK profile of LP-118 under ...

Chapel Hill, NCPHASE1100 participantsNewave Pharmaceutical Inc

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NCT06732388Recruiting

Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus

This phase II trial tests how well itraconazole works in combination with standard of care endoscopy with ablation for the prevention of esophageal cancer in patients with high-risk Barrett's esophagu...

Chapel Hill, NCPHASE276 participantsNational Cancer Institute (NCI)

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NCT04895436Recruiting

Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess retreatment with venetoclax-obinutuzumab (VenG) in participants previousl...

Chapel Hill, NCPHASE275 participantsAbbVie

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NCT06534060Recruiting

MB-105 in Patients With CD5 Positive T-cell Lymphoma

This is a single arm, two-stage, Phase 2, open-label, multicenter study of MB-105 in patients with CD5 Positive (CD5+) Relapsed / Refractory T-cell Lymphoma (r/r TCL). This study will apply a Simon tw...

Chapel Hill, NCPHASE246 participantsMarch Biosciences Inc

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NCT05654506Recruiting

Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits

The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in people with proliferative glomerulonephritis with monoclonal immunoglobulin...

Chapel Hill, NCPHASE240 participantsMayo Clinic

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NCT06860880Recruiting

Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

This health services study will assess a multidisciplinary intervention program directed at fatigue mitigation among patients diagnosed with indolent lymphomas. Specifically, 30 subjects with chronic ...

Chapel Hill, NCNA40 participantsUNC Lineberger Comprehensive Cancer Center

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NCT07073820Recruiting

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is h...

Chapel Hill, NCPHASE236 participantsPfizer

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NCT04083495Recruiting

CD30 CAR for Relapsed/Refractory CD30+ T Cell Lymphoma

This is a research study to determine the safety and tolerability of ATLCAR.CD30 for treating relapsed/refractory Peripheral T Cell Lymphoma. Blood samples will be collected from study participants an...

Chapel Hill, NCPHASE220 participantsUNC Lineberger Comprehensive Cancer Center

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NCT07112378Recruiting

A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

This study is researching an experimental drug called dupilumab (called "study drug"). The study is focused on children with active eosinophilic esophagitis (EoE; an inflammatory disease of the esopha...

Chapel Hill, NCPHASE320 participantsRegeneron Pharmaceuticals

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About Pulmonary Hypertension Clinical Trials in Chapel Hill

Pulmonary hypertension is a type of high blood pressure that affects the arteries in the lungs and the right side of the heart. It can lead to heart failure if untreated. Treatment includes vasodilators, endothelin receptor antagonists, and PDE-5 inhibitors.

There are currently 18 pulmonary hypertension clinical trials recruiting participants in Chapel Hill, NC. These studies are seeking a combined 10,584 participants. Research is being sponsored by Population Health Research Institute, Case Western Reserve University, Case Comprehensive Cancer Center and 13 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Pulmonary Hypertension Clinical Trials in Chapel Hill — FAQ

Are there pulmonary hypertension clinical trials in Chapel Hill?

Yes, there are 18 pulmonary hypertension clinical trials currently recruiting in Chapel Hill, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chapel Hill?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chapel Hill research site will contact you about next steps.

Are clinical trials in Chapel Hill free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chapel Hill studies also compensate for your time and travel.

What pulmonary hypertension treatments are being tested?

The 18 active trials in Chapel Hill are testing new therapies including novel drugs, biologics, and treatment approaches for pulmonary hypertension.

Data updated July 17, 2026 from ClinicalTrials.gov