4 Angelman Syndrome Clinical Trials in Chicago, IL (2026)

Q: How do I join a clinical trial in Chicago?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you.

Recruiting Angelman Syndrome Studies in Chicago

NCT04507997Recruiting

Angelman Syndrome Natural History Study

The goal of this study is to conduct a prospective, longitudinal natural history study of children and adults with Angelman Syndrome using investigator-observed and parent-reported outcome measures to...

Chicago, IL300 participantsBoston Children's Hospital

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NCT06914609Recruiting

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

The purpose of this study is to evaluate the efficacy and safety of ION582 in children and adults with Angelman syndrome caused by a deletion or mutation of the UBE3A gene....

Chicago, ILPHASE3158 participantsIonis Pharmaceuticals, Inc.

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NCT07157254Recruiting

A Safety and Efficacy Study of GTX-102 in Subjects With Deletion- or Nondeletion-type Angelman Syndrome (AS)

The main goal of the study is to evaluate the safety and efficacy of GTX-102 in participants with Angelman syndrome....

Chicago, ILPHASE260 participantsUltragenyx Pharmaceutical Inc

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NCT07181837Recruiting

A Phase 1/2 Study of the Safety and Efficacy of MVX-220 in Angelman Syndrome

The purpose of this study is to evaluate the safety and efficacy of MVX-220 gene therapy in children and adults with Angelman syndrome with UBE3A gene deletion, uniparental disomy, or imprinting cente...

Chicago, ILPHASE112 participantsMavriX Bio, LLC

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About Angelman Syndrome Clinical Trials in Chicago

Angelman syndrome is a rare genetic disorder primarily affecting the nervous system, characterized by severe developmental delays, speech impairment, seizures, and a happy demeanor. It is caused by loss of function of the UBE3A gene. Treatment focuses on managing symptoms and maximizing developmental potential.

There are currently 4 angelman syndrome clinical trials recruiting participants in Chicago, IL. These studies are seeking a combined 530 participants. Research is being sponsored by Boston Children's Hospital, Ionis Pharmaceuticals, Inc., Ultragenyx Pharmaceutical Inc and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Angelman Syndrome Clinical Trials in Chicago — FAQ

Are there angelman syndrome clinical trials in Chicago?

Yes, there are 4 angelman syndrome clinical trials currently recruiting in Chicago, IL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What angelman syndrome treatments are being tested?

The 4 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for angelman syndrome.

Data updated August 27, 2026 from ClinicalTrials.gov