Chicago, ILLINOIS5 Active Studies

Type 2 Diabetes Clinical Trials in Chicago, ILLINOIS

Find 5 actively recruiting type 2 diabetes clinical trials in Chicago, ILLINOIS. Connect with local research sites and explore new treatment options.

5
Active Trials
4
Sponsors
528
Enrolling

Recruiting Type 2 Diabetes Studies in Chicago

RecruitingChicago, ILLINOISNCT05476276

EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy

This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HE...

122 participants
James P. Rathmell, MD
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RecruitingChicago, ILLINOISNCT05480228

EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA

The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 13 wee...

122 participants
James P. Rathmell, MD
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RecruitingChicago, ILLINOISNCT07014176

Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)

The purpose of this study is to determine how well our dHPT (Dehydrated Human Placental Tissue) Product and Standard of Care work when compared to Standard of Care alone in achieving complete closure ...

120 participants
Cellution Biologics
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RecruitingChicago, ILLINOISNCT04128995

Surgical or Medical Treatment

This study will test the hypothesis that metabolic bariatric surgery will be more effective at providing durable glycemic control and reduce co-morbidities than intensive medical therapy in youth with...

100 participants
Children's Hospital Medical Center, Cincinnati
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RecruitingChicago, ILLINOISNCT06851858

Efficacy, Safety and Tolerability of AZD6234 in Participants Living With Overweight or Obesity With Type 2 Diabetes Who Are on a Stable Dose of GLP-1 Receptor Agonist

This Phase II study is a randomized, parallel group, double blinded, placebo-controlled, multicenter to evaluate the efficacy, safety, and tolerability of AZD6234 in adults with overweight or obesity ...

64 participants
AstraZeneca
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About Type 2 Diabetes Clinical Trials in Chicago

Type 2 diabetes is a chronic metabolic condition affecting over 37 million Americans, characterized by insulin resistance and progressive loss of beta-cell function. While metformin remains the first-line treatment, the treatment landscape has expanded dramatically with GLP-1 receptor agonists (semaglutide, tirzepatide), SGLT2 inhibitors (empagliflozin, dapagliflozin), and dual GIP/GLP-1 agonists showing both glycemic and cardiovascular benefits. Clinical trials are now exploring triple-hormone agonists, oral GLP-1 formulations, islet cell regeneration therapies, and precision medicine approaches that tailor treatment to individual metabolic profiles. Patients with uncontrolled HbA1c on current medications, those with diabetic complications, or newly diagnosed patients may qualify for enrollment.

There are currently 5 type 2 diabetes clinical trials recruiting participants in Chicago, ILLINOIS. These studies are seeking a combined 528 participants. Research is being sponsored by James P. Rathmell, MD, Cellution Biologics, Children's Hospital Medical Center, Cincinnati and 1 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Type 2 Diabetes Clinical Trials in Chicago — FAQ

Are there type 2 diabetes clinical trials in Chicago?

Yes, there are 5 type 2 diabetes clinical trials currently recruiting in Chicago, ILLINOIS. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Chicago?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Chicago research site will contact you about next steps.

Are clinical trials in Chicago free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Chicago studies also compensate for your time and travel.

What type 2 diabetes treatments are being tested?

The 5 active trials in Chicago are testing new therapies including novel drugs, biologics, and treatment approaches for type 2 diabetes.

Data updated March 2, 2026 from ClinicalTrials.gov