13 Liver Disease Clinical Trials in Cleveland, TX (2026)

Q: How do I join a clinical trial in Cleveland?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Cleveland research site will contact you.

Recruiting Liver Disease Studies in Cleveland

NCT04613921Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival...

Cleveland, TX3,000 participantsEuropean Foundation for Study of Chronic Liver Failure

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NCT03224949Recruiting

Comparison of ALD, NASH, and Healthy Control Patients

The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate heavy drinking, yet healthy controls and non-drinking healthy controls, ...

Cleveland, TX500 participantsThe Cleveland Clinic

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NCT05832229Recruiting

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

This is a double-blind, phase 2 study to evaluate safety and efficacy of rosuvastatin in comparison to placebo after 2 years in patients with compensated cirrhosis....

Cleveland, TX256 participantsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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NCT06374875Recruiting

Fibrosis Lessens After Metabolic Surgery

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), a major global public health concern, is commonly associated with obesity...

Cleveland, TX120 participantsAli Aminian

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NCT05490888Recruiting

Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

This 2-part study will evaluate PHIN-214 given as a single one-time dose (Part 1) and in multiple doses (given as daily doses for 28-days) (in Part 2). Specifically, this study evaluates PHIN-214, to ...

Cleveland, TX74 participantsPharmaIN

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NCT04858412Recruiting

Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19

Patients with COVID-19 and comorbidities including alcohol associated liver disease (ALD) are at risk for severe illness and abrupt or sudden clinical deterioration with ventilatory failure. â-hydroxy...

Cleveland, TX48 participantsThe Cleveland Clinic

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NCT03121404Recruiting

Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting

Cirrhosis is characterized by loss of muscle as well as fat mass, which increases morbidity and mortality before, during, and after liver transplantation. A common mechanism for the reduced muscle and...

Cleveland, TX40 participantsThe Cleveland Clinic

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NCT03209791Recruiting

Ethanol Induces Skeletal Muscle Autophagy

In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts....

Cleveland, TX40 participantsThe Cleveland Clinic

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NCT05982769Recruiting

Molecular Mechanism of Exercise in Cirrhosis

This study aims to investigate the effects of 12 weeks of resistance or endurance exercise on patients with cirrhosis. Cirrhotic patients are prone to muscle loss (sarcopenia) and ammonia build up due...

Cleveland, TX40 participantsThe Cleveland Clinic

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NCT03208868Recruiting

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

Loss of skeletal muscle mass or sarcopenia is the most common and potentially reversible complication in cirrhosis that increases morbidity and mortality before, during and after liver transplantation...

Cleveland, TX32 participantsThe Cleveland Clinic

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NCT05166499Recruiting

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

Cleveland, TX24 participantsThe Cleveland Clinic

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NCT03225677Recruiting

Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies....

Cleveland, TX20 participantsThe Cleveland Clinic

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NCT06477146Recruiting

Milk Thistle Clinical Trial in Pediatric NAFLD

Pediatric Fatty Liver disease is a growing problem in the United States and is expected to be the leading cause of Liver Transplantation in Adults in 20 years. Following lifestyle changes such as diet...

Cleveland, TX20 participantsUniversity Hospitals Cleveland Medical Center

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About Liver Disease Clinical Trials in Cleveland

Chronic liver disease encompasses conditions that damage the liver over time, including cirrhosis, hepatitis, and fatty liver disease. The liver plays a crucial role in digestion, metabolism, and detoxification. Treatment depends on the cause and may include medications, lifestyle changes, or liver transplant.

There are currently 13 liver disease clinical trials recruiting participants in Cleveland, TX. These studies are seeking a combined 4,214 participants. Research is being sponsored by European Foundation for Study of Chronic Liver Failure, The Cleveland Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Liver Disease Clinical Trials in Cleveland — FAQ

Are there liver disease clinical trials in Cleveland?

Yes, there are 13 liver disease clinical trials currently recruiting in Cleveland, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Cleveland?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Cleveland research site will contact you about next steps.

Are clinical trials in Cleveland free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Cleveland studies also compensate for your time and travel.

What liver disease treatments are being tested?

The 13 active trials in Cleveland are testing new therapies including novel drugs, biologics, and treatment approaches for liver disease.

Data updated July 13, 2026 from ClinicalTrials.gov