25 Pulmonary Hypertension Clinical Trials in Durham, NC (2026)

Q: Are there pulmonary hypertension clinical trials in Durham?

Yes, there are 25 pulmonary hypertension clinical trials currently recruiting in Durham, NC.

Q: How do I join a clinical trial in Durham?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Durham research site will contact you.

Q: Are clinical trials in Durham free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Pulmonary Hypertension Studies in Durham

NCT04774159Recruiting

Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk

The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular ...

Durham, NCPHASE36,150 participantsPopulation Health Research Institute

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NCT07609394Recruiting

Duchenne Electronic Health Record Study

This study aims to collect retrospective and prospective, long-term data of patients with dystrophinopathy (including Duchenne, Becker, and female carriers) through electronic transfer. At select clin...

Durham, NC2,500 participantsThe Duchenne Registry

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NCT03489278Recruiting

Clinical Procedures to Support Research in ALS

The purpose of the Clinical Procedures To Support Research (CAPTURE) study is to utilize information collected in the medical record to learn more about a disease called amyotrophic lateral sclerosis ...

Durham, NC1,200 participantsUniversity of Miami

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NCT07674758Recruiting

Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials

Dystrophin associated heart dysfunction is a leading cause of death in patients with Duchenne and Becker Muscular dystrophy (DMD/BMD) and Duchenne and Becker muscular dystrophy carriers (MDC); however...

Durham, NC1,000 participantsVanderbilt University Medical Center

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NCT05150197Recruiting

Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease

The purpose of this study is to test a new way of measuring the peripheral vision (called a visual field test) using a device which can be worn as goggles rather than being a large instrument the pati...

Durham, NCNA1,000 participantsDuke University

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NCT07634471Recruiting

A Clinical Trial of MK-1045 and Rituximab in People With Follicular Lymphoma (MK-1045-007)

Researchers are looking for new ways to treat follicular lymphoma (FL). A standard (usual) treatment for FL includes a targeted therapy called rituximab and chemotherapy. In this study, researchers wa...

Durham, NCPHASE2960 participantsMerck Sharp & Dohme LLC

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NCT07127978Recruiting

A Study Evaluating the Real-World Experience of Givinostat in Patients With Duchenne Muscular Dystrophy

This is a prospective observational study conducted to evaluate safety, tolerability, and functional outcomes of patients with DMD newly initiating oral givinostat or having started therapy within 6 m...

Durham, NC300 participantsITF Therapeutics LLC

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NCT07038200Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)...

Durham, NCPHASE3200 participantsAvidity Biosciences, Inc.

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NCT07215507Recruiting

Timing of Physician Rounds for Antepartum Patients

This study will include patients admitted to the Antepartum service at Duke University Hospital, many of whom are managing high-risk pregnancies that require extended hospital stays and frequent physi...

Durham, NCNA200 participantsDuke University

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NCT06581198Recruiting

A Study of Rapcabtagene Autoleucel in Systemic Lupus Erythematosus (SLE) Patients With Active, Refractory Lupus Nephritis (LN)

The purpose of this study is to evaluate the efficacy and safety of rapcabtagene autoleucel (administered once following lymphodepletion) versus Standard of Care (SOC) in patients with systemic lupus ...

Durham, NCPHASE2179 participantsNovartis Pharmaceuticals

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NCT07284186Recruiting

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

A multicenter, single-arm, first-in-human study to investigate the safety, pharmacokinetics, and preliminary antitumor activity of PLX-61639 in participants with locally advanced or metastatic, relaps...

Durham, NCPHASE1155 participantsPlexium, Inc.

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NCT07488676Recruiting

A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

This study will help find the most suitable dose of ASP546C in people with gastric cancer, gastroesophageal junction (GEJ) cancer, pancreatic cancer, and other specific solid tumors. GEJ is where the ...

Durham, NCPHASE1150 participantsAstellas Pharma Global Development, Inc.

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NCT04302272Recruiting

STRIVE Post-Market Registry Study

This is a single-arm, prospective, multi-center, Registry study to evaluate the long-term safety and effectiveness of the Spiration Valve System (SVS) for the treatment of severe emphysema in a post-m...

Durham, NC150 participantsOlympus Corporation of the Americas

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NCT06116110Recruiting

Lentiviral Gene Therapy (Zamtocabtagene Autoleucel) LTFU

This is an observational long-term follow-up (LTFU) study for subjects who previously received zamtocabtagene autoleucel, known as MB-CART2019.1....

Durham, NC150 participantsMiltenyi Biomedicine GmbH

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NCT03666000Recruiting

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T,...

Durham, NCPHASE1135 participantsImugene Limited

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NCT04858256Recruiting

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

The main purpose of this study is to determine the effectiveness of the study drug pacritinib in people with relapsed or refractory lymphoproliferative disorders....

Durham, NCPHASE2100 participantsUniversity of Michigan Rogel Cancer Center

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NCT06520098Recruiting

A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

People who have chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) are often treated with ibrutinib, acalabrutinib, or zanubrutinib. These are pills that are taken by mouth. This t...

Durham, NCPHASE2100 participantsVA Office of Research and Development

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NCT05563766Recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

Esophageal cancer, which has a low 5-year overall survival rate (\<20%) is increasing in incidence. Previous studies have shown that Hedgehog, AKT, and angiogenic signaling pathways are activated in a...

Durham, NCPHASE278 participantsVA Office of Research and Development

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NCT04747236Recruiting

Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL

The purpose of this study is to find out whether the combination treatment of romidepsin and oral azacytidine is safe and effective in patients with Peripheral T-Cell Lymphoma (PTCL). This study will ...

Durham, NCPHASE250 participantsUniversity of Virginia

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NCT05233397Recruiting

ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

ACTEMRA (tocilizumab) is an IL-6 receptor antagonist used for the treatment of adult Rheumatoid Arthritis as well as Polyarticular (PJIA) and Systemic (SJIA) Juvenile Idiopathic Arthritis. In this Pha...

Durham, NCPHASE230 participantsNationwide Children's Hospital

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NCT05671757Recruiting

Daratumumab in Primary Antiphospholipid Syndrome

The purpose of this study is to see if the study medication, daratumumab, is safe to treat individuals with Anti-Phospholipid Syndrome (APS). Three daratumumab dosing cohorts are planned with up to s...

Durham, NCPHASE122 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT04991454Recruiting

Xenon MRI Pulm Hypertension

The overall objective outlined in this study is to determine how pulmonary vascular remodeling in PAH at a cellular and pathological level is associated with changes in gas exchange physiology and hem...

Durham, NCPHASE220 participantsBastiaan Driehuys

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NCT06104228Recruiting

129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

The overall study objectives outlined in this study are to derive 129Xe MRI pulmonary vascular biomarker signatures that differentiate common subtypes of PAH and to determine the ability of 129Xe MRI ...

Durham, NCPHASE220 participantsBastiaan Driehuys

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NCT05140525Recruiting

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

The main goal of this study is to determine the effects of combination medical therapy (Riociguat and Macitentan) and balloon pulmonary angioplasty (BPA) on hemodynamics and right ventricular (RV) fun...

Durham, NCPHASE315 participantsDr Sudarshan Rajagopal

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NCT06351345Recruiting

129 Xenon Imaging in Patients Treated With Sotatercept

Determine the ability of 129Xe MRI/MRS biomarker signatures to non-invasively monitor pulmonary vascular reverse remodeling induced by sotatercept in pulmonary arterial hypertension (PAH)....

Durham, NCPHASE214 participantsBastiaan Driehuys

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About Pulmonary Hypertension Clinical Trials in Durham

Pulmonary hypertension is a type of high blood pressure that affects the arteries in the lungs and the right side of the heart. It can lead to heart failure if untreated. Treatment includes vasodilators, endothelin receptor antagonists, and PDE-5 inhibitors.

There are currently 25 pulmonary hypertension clinical trials recruiting participants in Durham, NC. These studies are seeking a combined 14,878 participants. Research is being sponsored by Population Health Research Institute, The Duchenne Registry, University of Miami and 18 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Pulmonary Hypertension Clinical Trials in Durham — FAQ

Are there pulmonary hypertension clinical trials in Durham?

Yes, there are 25 pulmonary hypertension clinical trials currently recruiting in Durham, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Durham?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Durham research site will contact you about next steps.

Are clinical trials in Durham free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Durham studies also compensate for your time and travel.

What pulmonary hypertension treatments are being tested?

The 25 active trials in Durham are testing new therapies including novel drugs, biologics, and treatment approaches for pulmonary hypertension.

Data updated September 1, 2026 from ClinicalTrials.gov