26 Rheumatoid Arthritis Clinical Trials in Gainesville, FL (2026)

Q: How do I join a clinical trial in Gainesville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Gainesville research site will contact you.

Recruiting Rheumatoid Arthritis Studies in Gainesville

NCT05366881Recruiting

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers inc...

Gainesville, FL7,000 participantsAdela, Inc

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NCT07440225Recruiting

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person...

Gainesville, FLPHASE2960 participantsEyeBiotech Ltd.

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NCT05816382Recruiting

A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions

The main aim is to evaluate the safety and tolerability of TAK-861 on participants with type 1 narcolepsy, who were exposed to previously tested doses of TAK-861....

Gainesville, FLPHASE2500 participantsTakeda

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NCT05421741Recruiting

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treated with traditional standard of care intra...

Gainesville, FLPHASE4484 participantsWake Forest University Health Sciences

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NCT02577731Recruiting

Hematopoietic Stem Cell Dysfunction in the Elderly After Severe Injury

Traumatic injury is a leading cause of morbidity and mortality in young adults, and remains a substantial economic and health care burden. Despite decades of promising preclinical and clinical investi...

Gainesville, FLNA400 participantsUniversity of Florida

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NCT06033196Recruiting

Tocilizumab in Lung Transplantation

This is a trial in which 350 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or p...

Gainesville, FLPHASE2350 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT05615844Recruiting

Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy

The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries. Eligible participant...

Gainesville, FLPHASE3312 participantsUniversity of Maryland, Baltimore

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NCT06635148Recruiting

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

The purpose of this study is to assess the long-term safety and tolerability after an intravitreal injection (a shot of medicine into the eye) of JNJ-81201887 administered in parent clinical studies....

Gainesville, FLPHASE2274 participantsJanssen Research & Development, LLC

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NCT05616130Recruiting

Pathological Myeloid Activation After Sepsis and Trauma

The goal of this observational study is to better understand what happens to circulating blood after a patient experiences severe trauma injury. The main questions it aims to answer are: Is severe hum...

Gainesville, FL255 participantsUniversity of Florida

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NCT06213649Recruiting

Parasitic Ulcer Treatment Trial

The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regime...

Gainesville, FLPHASE3232 participantsJeremy Keenan, MD, MPH

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NCT03170440Recruiting

Non-invasive Nerve Stimulation for PTSD and Sleep

In this study, our objective is to determine the effect of two different nerve stimulation types in changing sleep architecture....

Gainesville, FLNA221 participantsUniversity of Florida

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NCT05197270Recruiting

4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration

Phase 1/2 dose-escalation and randomized, controlled, masked expansion trial in adults with wet AMD undergoing active anti-VEGF treatment. Substudies will evaluate the safety and tolerability of 4D-1...

Gainesville, FLPHASE1215 participants4D Molecular Therapeutics

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NCT07038200Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)...

Gainesville, FLPHASE3200 participantsAvidity Biosciences, Inc.

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NCT06393712Recruiting

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

The purpose of the study is to evaluate the effect of ALN-APP on measures of CAA disease progression and to characterize the safety, tolerability, and pharmacodynamics (PD) of ALN-APP in adult patient...

Gainesville, FLPHASE2200 participantsAlnylam Pharmaceuticals

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NCT06701682Recruiting

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort A: Vilobelimab

This is a Phase 2 multicenter, randomized, double-blinded, placebo-controlled study that will evaluate the safety and efficacy of host-directed therapeutics in hospitalized adults diagnosed with Acute...

Gainesville, FLPHASE2200 participantsPPD Development, LP

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NCT06008795Recruiting

BLOCK-SAH - PPF-Block for Post-SAH Headache

BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injecti...

Gainesville, FLPHASE2195 participantsUniversity of Florida

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NCT05014971Recruiting

Telehealth in Lewy Body Dementia

Lewy body dementia (LBD) is the 2nd most common neurodegenerative dementia in the US. Optimal care requires an interdisciplinary approach, however often faced barriers include rural residence, limited...

Gainesville, FLNA106 participantsUniversity of Florida

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NCT05792189Recruiting

Distal Femur Fx: ORIF(Open Reduction and Internal Fixation) vs DFR (Distal Femur Replacement Total Knee Arthroplasty)

Supracondylar femur periprosthetic fractures about a total knee arthroplasty (TKA) are a catastrophic and challenging complication of TKA and unfortunately are increasing in incidence. Fixation of the...

Gainesville, FLNA100 participantsUniversity of Florida

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NCT07325188Recruiting

HUD Surgical Guidance for Toric Alignment

This study aims to assess the accuracy of toric intraocular lens (IOL) alignment axes as calculated and displayed by a novel digital guidance system. In addition, it evaluates the time required to ini...

Gainesville, FLNA100 participantsGainesville Eye Associates

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NCT06774131Recruiting

A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer

This study will evaluate the efficacy and safety of UGN-104, a new formulation of UGN-101 (approved in the United States and Israel as JELMYTO \[mitomycin\] for pyelocalyceal solution), instilled in t...

Gainesville, FLPHASE370 participantsUroGen Pharma Ltd.

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NCT05714150Recruiting

Balance After Traumatic Brain Injury

A moderate traumatic brain injury (TBI) occurring in early or middle adulthood might have long-lasting effects on the brain that can accelerate the decline of physical and cognitive function in older ...

Gainesville, FLNA70 participantsVA Office of Research and Development

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NCT06660667Recruiting

A Safety and Efficacy Study of One-time SAR402663 in Adults With Neovascular Age-related Macular Degeneration

This is a Phase 1/Phase 2 multicenter study to evaluate the safety and efficacy of a one-time single-eye intravitreal dose of SAR402663 in participants with neovascular age-related macular degeneratio...

Gainesville, FLPHASE166 participantsSanofi

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NCT05465174Recruiting

Tovorafenib for Treatment of Craniopharyngioma in Children and Young Adults

The current study assesses the tolerability and efficacy of monotherapy with pan-RAF-kinase (Tovorafenib) inhibition for the treatment of children and young adults with craniopharyngioma....

Gainesville, FLPHASE257 participantsSabine Mueller, MD, PhD

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NCT06263322Recruiting

The ROAMM-EHR Study

In recent years, mobile health (mHealth) apps have promised improved monitoring of health conditions to improve clinical outcomes. The objective of this study is to conduct a pilot randomized clinical...

Gainesville, FLNA50 participantsUniversity of Florida

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NCT05819866Recruiting

A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy

A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adults Male Subjects with Cerebral Adrenoleukodystrophy....

Gainesville, FLPHASE340 participantsMinoryx Therapeutics, S.L.

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NCT07465302Recruiting

Treating Spinal Cord Injury With Early Normobaric Hyperoxia

SpiCoH is a phase IIa, single center, open-label, clinical trial of intermittent normobaric hyperoxia in mechanically ventilated patients with traumatic cervical and/or thoracic spinal cord injury....

Gainesville, FLPHASE212 participantsUniversity of Florida

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About Rheumatoid Arthritis Clinical Trials in Gainesville

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1.3 million Americans, where the immune system mistakenly attacks joint linings, causing painful swelling, bone erosion, and joint deformity. Early diagnosis and treatment are critical to prevent irreversible damage. Current standard treatments include methotrexate and other DMARDs, TNF inhibitors (etanercept, infliximab), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and JAK inhibitors (tofacitinib, baricitinib). Clinical trials are now exploring next-generation targeted therapies, dual-pathway inhibitors, and treatment strategies aimed at achieving sustained remission rather than just symptom control. Patients with inadequate response to conventional DMARDs or biologics are commonly eligible for enrollment.

There are currently 26 rheumatoid arthritis clinical trials recruiting participants in Gainesville, FL. These studies are seeking a combined 12,669 participants. Research is being sponsored by Adela, Inc, EyeBiotech Ltd., Takeda and 16 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Rheumatoid Arthritis Clinical Trials in Gainesville — FAQ

Are there rheumatoid arthritis clinical trials in Gainesville?

Yes, there are 26 rheumatoid arthritis clinical trials currently recruiting in Gainesville, FL. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Gainesville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Gainesville research site will contact you about next steps.

Are clinical trials in Gainesville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Gainesville studies also compensate for your time and travel.

What rheumatoid arthritis treatments are being tested?

The 26 active trials in Gainesville are testing new therapies including novel drugs, biologics, and treatment approaches for rheumatoid arthritis.

Data updated July 17, 2026 from ClinicalTrials.gov