29 Prostate Cancer Clinical Trials in Houston, NC (2026)

Q: How do I join a clinical trial in Houston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you.

Recruiting Prostate Cancer Studies in Houston

NCT07365995Recruiting

A Phase III Trial of BNT324 Versus Docetaxel in Metastatic Castration-resistant Prostate Cancer

This study will test whether BNT324 is safe and works better against metastatic castration-resistant prostate cancer (mCRPC) than the current standard of care (SoC) chemotherapy, which is docetaxel (g...

Houston, NC736 participantsBioNTech SE

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NCT05997615Recruiting

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

The study will be conducted in 4 parts and will commence with dose escalation of VIR-5500 as a monotherapy (Part 1), followed by combination escalation (Part 3a), monotherapy dose expansion (Part 2) a...

Houston, NC437 participantsVir Biotechnology, Inc.

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NCT04812366Recruiting

Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer

The objective of this study is to see if providing an appropriate therapy based on the genomic testing of prostate tumour tissue will result in an improved clinical response. Each participant will be...

Houston, NC315 participantsUniversity of British Columbia

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NCT05043012Recruiting

Diagnostic Performance Of Non-Endorectal Coil Multiparametric Magnetic Resonance Imaging Of Prostate With Flexible AIR Coil (DoNEMAC Study)

Multiparametric MRI (mpMRI) of the prostate is an important tool for diagnosis of clinically significant prostate cancer (csPCa) in men with an elevated serum prostate specific antigen, which can decr...

Houston, NC258 participantsM.D. Anderson Cancer Center

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NCT05125016Recruiting

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer

This study is researching an investigational drug called REGN4336. Some participants may receive additional investigational drugs in combination with REGN4336. These additional drugs include REGN5678,...

Houston, NC228 participantsRegeneron Pharmaceuticals

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NCT04947254Recruiting

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

This phase II trial studies the effect of androgen ablation therapy with or without niraparib after standard of care radiation therapy in treating patients with prostate cancer that has not spread to ...

Houston, NC200 participantsM.D. Anderson Cancer Center

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NCT05054296Recruiting

Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring

This phase II trial studies how well an exercise program and continuous Fitbit monitoring work for managing metabolic syndrome and cardiovascular disease risk in patients with prostate cancer that has...

Houston, NC200 participantsM.D. Anderson Cancer Center

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NCT06217822Recruiting

First-in-human Study of 225Ac-PSMA-Trillium (BAY 3563254) in Participants With Advanced Metastatic Castration-resistant Prostate Cancer (mCRPC)

Researchers are looking for a better way to treat participants who have metastatic castration-resistant prostate cancer (mCRPC). mCRPC is a cancer of the prostate (male reproductive gland found below...

Houston, NC198 participantsBayer

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NCT06785441Recruiting

Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Efficacy Testing

This protocol describes pilot testing of an educational shared decision-making intervention to help men with localized prostate cancer make decisions with their health care providers about if and when...

Houston, NC180 participantsM.D. Anderson Cancer Center

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NCT07590934Recruiting

Phase Ib/II Platform Study of Multiple Anti-Cancer Agents in Participants With Metastatic Prostate Cancer

The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of multiple anti-cancer agents in participants with metastatic prost...

Houston, NC152 participantsAstraZeneca

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NCT03833921Recruiting

Evaluation of Response to Abiraterone/Prednisone by Race/Ethnicity and Other Factors in Metastatic Hormone Naive Prostate Cancer

The investigators are conducting this study with men that have prostate cancer and are getting standard of care treatment with the drugs abiraterone acetate and prednisone. The study will follow men w...

Houston, NC130 participantsMartha Mims

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NCT05840484Recruiting

Comprehensive Monitoring of Men With Prostate Cancer Cared for by "Active Surveillance

Prostate cancer is the most commonly diagnosed cancer in men. However, there is a wide range in prognosis determined by a host of factors. This study will evaluate the feasibility of guiding therapeut...

Houston, NC100 participantsM.D. Anderson Cancer Center

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NCT06609005Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of INV-9956 in Adult Patients With Advanced Metastatic Castration Resistant Prostate Cancer

This is a Phase 1 and Phase 2 study to determine the safety profile, RDR and/or MTD, DLT, PK/PD, and preliminary antitumor activity of INV-9956 in adult patients with advanced mCRPC....

Houston, NC84 participantsShenzhen Ionova Life Sciences Co., Ltd.

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NCT06496256Recruiting

Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

Barrigel is intended to temporarily position the anterior rectal wall away from the prostate or prostate bed during radiotherapy treatment for prostate cancer and, in creating this space, it is the in...

Houston, NC84 participantsPalette Life Sciences, Inc.

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NCT05488548Recruiting

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

A Phase 1, first-in-human study of EP31670, a dual BET and CBP/p300 inhibitor in patients with targeted advanced solid tumors and Hematological Malignancies...

Houston, NC75 participantsEpigenetix, Inc.

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NCT06782555Recruiting

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

The purpose of this Phase 1/2 study is to test the overall safety, tolerability, and effectiveness of the combination investigational drugs evofosfamide, zalifrelimab, and balstilimab in treating adva...

Houston, NC71 participantsImmunoGenesis

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NCT06369246Recruiting

PRORAD-5 PROstate RADiation in 5 Fractions: Phase II Five Fraction Radiotherapy for Patients With Advanced Prostate Cancer.

To look at the safety and effectiveness of stereotactic body radiation therapy (SBRT) in treating advanced or high-risk prostate cancer....

Houston, NC70 participantsM.D. Anderson Cancer Center

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NCT07591701Recruiting

Efforts to Increase Representation in Prostate Cancer Clinical Trials at Lyndon B. Johnson Hospital

The main rationale underlying this study is that prostate cancer clinical trials are lacking representation from racial and ethnic minority groups. Study proposal aims to target barriers at the partic...

Houston, NC60 participantsM.D. Anderson Cancer Center

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NCT06826768Recruiting

A Ph Ib Study of REGN5678 Plus Cemiplimab in Patients With mCRPC

A single-center phase Ib/II dose escalation and dose-expansion clinical trial of REGN5678 plus cemiplimab...

Houston, NC60 participantsM.D. Anderson Cancer Center

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NCT05497024Recruiting

Older Men's Decision Making About Active Surveillance for Prostate Cancer - Aim 3: Decision Aid Cognitive and Usability Testing

This protocol describes development and user testing of an educational shared decision making intervention to help men with prostate cancer who are on active surveillance make decisions with their hea...

Houston, NC45 participantsM.D. Anderson Cancer Center

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NCT06085664Recruiting

A Pilot Presurgical Trial of REGN5678 (Anti-PSMA x CD28) in Patients With High-risk, Localized Prostate Cancer Followed by Radical Prostatectomy

To learn about the safety and effects of a drug called REGN5678 when it is given to patients with high-risk prostate cancer....

Houston, NC42 participantsM.D. Anderson Cancer Center

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NCT04693377Recruiting

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

This trial compares cryoablation combined with stereotactic body radiation therapy to stereotactic body radiation therapy alone to see how well they work in treating patients with pain from cancer tha...

Houston, NC40 participantsM.D. Anderson Cancer Center

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NCT05691465Recruiting

Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

This phase II trial studies how well lutetium Lu 177 dotatate works in treating patients with prostate cancer with neuroendocrine differentiation that has spread to other places in the body (metastati...

Houston, NC35 participantsNational Cancer Institute (NCI)

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NCT06815354Recruiting

Comprehensive Assessment of Cancer Theranostic Response

The intent of this study is to evaluate actionable outputs from TRAQinform Theranostics in a prospective, multi-center, non-interventional clinical study. The primary objective is to investigate inten...

Houston, NC32 participantsAIQ Solutions

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NCT06085729Recruiting

Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)

To find the best dose of ADI-PEG20 that can be given in combination with carboplatin and cabazitaxel to patients with AVPC....

Houston, NC30 participantsM.D. Anderson Cancer Center

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NCT05873192Recruiting

Presurgical Phase II Study of Talazoparib in Combination With Enzalutamide in Prostate Cancer

To learn about the effectiveness of adding talazoparib to the standard of care treatment combination of androgen ablation therapy (hormone therapy, also known as ADT) and enzalutamide in patients with...

Houston, NC30 participantsM.D. Anderson Cancer Center

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NCT06972628Recruiting

Treatment of Patients With Progressive mCRPC With 177Lu-PSMA-617

The purpose of this study is to evaluate the safety and tolerability of Lutetium-177-PSMA-617 (PLUVICTO) in patients with metastatic castration-resistant prostate cancer (mCRPC) and extensive bone met...

Houston, NC30 participantsEbrahim S Delpassand

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NCT05454488Recruiting

An Evidence-Based Focal Cryotherapy Protocol for Focal Ablation of Intermediate Risk Prostate Cancer

To learn if using cryotherapy to treat only the part of the prostate known to contain cancer is effective in controlling prostate cancer...

Houston, NC30 participantsM.D. Anderson Cancer Center

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NCT07182279Recruiting

Neoadjuvant High Dose Rate Brachytherapy Prior to Radical Prostatectomy in Patients With Prostate Cancer

This is a Phase I/II trial evaluating the effectiveness of adding neoadjuvant HDR-B prior to RALP for HR-PCa patients with selective AAB for decipher high risk or pathologically node positive patients...

Houston, NC29 participantsThe Methodist Hospital Research Institute

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About Prostate Cancer Clinical Trials in Houston

Prostate cancer develops in the prostate gland and is one of the most common cancers in men. Many prostate cancers grow slowly, but some can be aggressive. Treatment options range from active surveillance to surgery, radiation, and hormone therapy.

There are currently 29 prostate cancer clinical trials recruiting participants in Houston, NC. These studies are seeking a combined 3,981 participants. Research is being sponsored by BioNTech SE, Vir Biotechnology, Inc., University of British Columbia and 13 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Prostate Cancer Clinical Trials in Houston — FAQ

Are there prostate cancer clinical trials in Houston?

Yes, there are 29 prostate cancer clinical trials currently recruiting in Houston, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Houston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you about next steps.

Are clinical trials in Houston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Houston studies also compensate for your time and travel.

What prostate cancer treatments are being tested?

The 29 active trials in Houston are testing new therapies including novel drugs, biologics, and treatment approaches for prostate cancer.

Data updated July 13, 2026 from ClinicalTrials.gov