12 Sarcoma Soft Tissue Clinical Trials in Houston, TX (2026)

Q: How do I join a clinical trial in Houston?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you.

Recruiting Sarcoma Soft Tissue Studies in Houston

NCT06797999Recruiting

First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma

The goal of this clinical trial is to learn about the safety, tolerability and efficacy of ADCE-D01....

Houston, TXPHASE1270 participantsAdcendo ApS

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NCT04751409Recruiting

Evaluating the Impact of Limited Compared With Intense Post-Operative Surveillance on Patient-Reported Outcomes in Patients With Stage II-III Soft Tissue Sarcoma of the Trunk and Extremities

This phase II trial studies how anxiety is affected by 2 types of follow-up after surgery, limited follow-up and intense follow-up, in patients with stage II-III soft tissue sarcoma of the trunk and e...

Houston, TXPHASE2227 participantsM.D. Anderson Cancer Center

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NCT05653388Recruiting

Metastatic Leiomyosarcoma Biomarker Protocol

Leiomyosarcoma (LMS) is one of the most prevalent soft tissue sarcomas (STS) and can occur in various sites including soft tissue, uterus and retroperitoneal large vessels. Metastatic disease occurs i...

Houston, TX200 participantsUniversity of Michigan Rogel Cancer Center

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NCT06574269Recruiting

A Study on TLC590 for Managing Postsurgical Pain

This Phase 2 open-label trial investigates the pharmacokinetics (PK), pharmacodynamics, and safety profile of TLC590 across various surgical procedures. Researchers aim to determine the maximum tolera...

Houston, TXPHASE2120 participantsTaiwan Liposome Company

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NCT07377747Recruiting

Prospective Study Evaluating the Treatment Outcomes for Localised Recurrent, Resectable Retroperitoneal Liposarcoma

The aim of the study is to collect prospective data on the treatment outcomes in patients with first localized, resectable recurrent retroperitoneal well-differentiated and/or dedifferentiated liposar...

Houston, TX100 participantsAustralia and New Zealand Sarcoma Association

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NCT06498648Recruiting

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

This phase I/II trial tests the side effects and best dose of abemaciclib when added to gemcitabine and compares the effectiveness of that treatment to the usual treatment of gemcitabine with docetaxe...

Houston, TXPHASE174 participantsNational Cancer Institute (NCI)

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NCT07049848Recruiting

SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma

The goal of this clinical research study is to look at the effectiveness of giving a combination of chemotherapy, immunotherapy, radiation therapy, and surgery to treat soft tissue sarcomas that can b...

Houston, TXPHASE250 participantsM.D. Anderson Cancer Center

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NCT07076186Recruiting

Phase II Decentralized Pragmatic Trial of Adjuvant Doxorubicin - Trabectedin Chemotherapy in uLMS

To find out if receiving standard chemotherapy (doxorubicin and trabectedin) can extend the cancer-free survival of patients with Stage 1b/2 uterine leiomyosarcoma who had surgery that fully removed t...

Houston, TXPHASE248 participantsM.D. Anderson Cancer Center

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NCT07156565Recruiting

Actinium Therapy for Late-stage Aggressive Sarcomas

The goal of this clinical trial is to learn about the safety of drug \[Ac225\]RTX-2358 and the diagnostic imaging agent \[Cu64\]LNTH-1363S. Additionally Ratio Therapeutics will learn if \[Ac225\]RTX-2...

Houston, TXPHASE148 participantsRatio Therapeutics, Inc.

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NCT06083883Recruiting

Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1

The goal of this clinical research study is to find a recommended dose of donated NK cells that can be given along with chemotherapy to patients with advanced cancers. The safety and effects of this t...

Houston, TXPHASE144 participantsM.D. Anderson Cancer Center

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NCT03896269Recruiting

CPX-351 in Treating Patients With Relapsed or Refractory High Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

This phase I trial studies best dose and side effects of liposome-encapsulated daunorubicin-cytarabine (CPX-351) and how well it works in treating patients with high risk myelodysplastic syndrome or c...

Houston, TXPHASE138 participantsM.D. Anderson Cancer Center

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NCT07444619Recruiting

A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas

The goal of this study is to build on the experience of the SAINT trial by evaluating the safety and efficacy of the addition of pazopanib to their published chemotherapy regimen....

Houston, TXPHASE118 participantsM.D. Anderson Cancer Center

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About Sarcoma Soft Tissue Clinical Trials in Houston

Soft tissue sarcomas are rare cancers that develop in the soft tissues of the body including muscle, fat, blood vessels, and tendons. There are more than 50 subtypes, each with different characteristics. Treatment includes surgery, radiation, and chemotherapy, with newer targeted therapies under investigation.

There are currently 12 sarcoma soft tissue clinical trials recruiting participants in Houston, TX. These studies are seeking a combined 1,237 participants. Research is being sponsored by Adcendo ApS, M.D. Anderson Cancer Center, University of Michigan Rogel Cancer Center and 4 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Sarcoma Soft Tissue Clinical Trials in Houston — FAQ

Are there sarcoma soft tissue clinical trials in Houston?

Yes, there are 12 sarcoma soft tissue clinical trials currently recruiting in Houston, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Houston?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Houston research site will contact you about next steps.

Are clinical trials in Houston free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Houston studies also compensate for your time and travel.

What sarcoma soft tissue treatments are being tested?

The 12 active trials in Houston are testing new therapies including novel drugs, biologics, and treatment approaches for sarcoma soft tissue.

Data updated October 15, 2026 from ClinicalTrials.gov