11 Prostate Cancer Clinical Trials in Indianapolis, IN (2026)

Q: How do I join a clinical trial in Indianapolis?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Indianapolis research site will contact you.

Recruiting Prostate Cancer Studies in Indianapolis

NCT04221542Recruiting

Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

The overall aim of the trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of AMG 509 (monotherapy and in combination with abiraterone acetate and enzalutamide) and to evaluate pr...

Indianapolis, INPHASE1479 participantsAmgen

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NCT04787744Recruiting

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

This is a prospective, open-label, multi-center seamless phase II to phase III randomized clinical trial designed to compare SST with or without PET-directed local therapy in improving the castration-...

Indianapolis, INPHASE2464 participantsVA Office of Research and Development

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NCT06780670Recruiting

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

This is a Phase II/III study. Patient population is adult participants with PSMA-positive mCRPC who had treatments with androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy and pro...

Indianapolis, INPHASE2443 participantsNovartis Pharmaceuticals

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NCT06056830Recruiting

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

The aim for this study is to assess the diagnostic performance of 64Cu-SAR-bisPSMA PET to detect regional nodal metastases....

Indianapolis, INPHASE3383 participantsClarity Pharmaceuticals Ltd

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NCT05381103Recruiting

PSMA-PET to Guide Prostatectomy

In this study, 196 patients will be randomized 1:1 to either having only the standard of care MRI prior to surgery versus having the standard of care MRI and the PSMA PET scan. PET (and MRI) findings ...

Indianapolis, INPHASE2288 participantsFive Eleven Pharma, Inc.

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NCT06873581Recruiting

Pivotal Study of Voro Urologic Scaffold

The objective of this study is to compare safety and effectiveness of the Voro Urologic Scaffold in adult men undergoing robotic assisted radical prostatectomy as compared to control arm. The study i...

Indianapolis, INPHASE3266 participantsLevee Medical, Inc.

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NCT06785636Recruiting

Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617

This is a dose-finding study to assess the safety and preliminary antitumor activity of Pocenbrodib alone or with Abiraterone acetate, Olaparib or 177Lu-PSMA-617 in patients with metastatic castration...

Indianapolis, INPHASE1120 participantsPathos AI, Inc.

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NCT05879913Recruiting

ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

This is a randomized pilot study of Coronary CT Angiography (CCTA) for coronary atherosclerosis vs. Usual Care in patients with prostate cancer who are either planning to begin, or are currently takin...

Indianapolis, INNA100 participantsIndiana University

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NCT06084338Recruiting

Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc

This trial tests if the combination of comprehensive metastasis directed therapy delivered by a precision form of external beam radiotherapy (stereotactic ablative radiotherapy), combined with PSMA ta...

Indianapolis, INPHASE260 participantsVA Office of Research and Development

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NCT06817668Recruiting

Evaluating Tolerability of ePUHRT With Brachytherapy Boost

The purpose of this study is to evaluate the tolerability and toxicity of combining two radiation therapy methods for prostate cancer: Elective Pelvic Ultra Hypofractionated Irradiation Treatment (ePU...

Indianapolis, INNA31 participantsIndiana University

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NCT06849544Recruiting

Phase II Trial to Investigate the Safety and Efficacy of Four Dosing Regimens of OTL78 Injection

This study is being done to compare how well Zopocianine (OTL78) in combination with Near InfraRed (NIR) fluorescent imaging may improve the detection of malignant (growing in an uncontrolled way) tis...

Indianapolis, INPHASE222 participantsClinton Bahler

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About Prostate Cancer Clinical Trials in Indianapolis

Prostate cancer develops in the prostate gland and is one of the most common cancers in men. Many prostate cancers grow slowly, but some can be aggressive. Treatment options range from active surveillance to surgery, radiation, and hormone therapy.

There are currently 11 prostate cancer clinical trials recruiting participants in Indianapolis, IN. These studies are seeking a combined 2,656 participants. Research is being sponsored by Amgen, VA Office of Research and Development, Novartis Pharmaceuticals and 6 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Prostate Cancer Clinical Trials in Indianapolis — FAQ

Are there prostate cancer clinical trials in Indianapolis?

Yes, there are 11 prostate cancer clinical trials currently recruiting in Indianapolis, IN. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Indianapolis?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Indianapolis research site will contact you about next steps.

Are clinical trials in Indianapolis free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Indianapolis studies also compensate for your time and travel.

What prostate cancer treatments are being tested?

The 11 active trials in Indianapolis are testing new therapies including novel drugs, biologics, and treatment approaches for prostate cancer.

Data updated July 17, 2026 from ClinicalTrials.gov