27 Myalgic Encephalomyelitis Clinical Trials in Irvine, CA (2026)

Q: How do I join a clinical trial in Irvine?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Irvine research site will contact you.

Recruiting Myalgic Encephalomyelitis Studies in Irvine

NCT07177352Recruiting

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

This study is a pre-screening process used to assess participants' potential eligibility for Roche interventional Alzheimer's disease studies....

Irvine, CAPHASE380,000 participantsHoffmann-La Roche

View Study Details

NCT03860883Recruiting

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. Thi...

Irvine, CANA2,998 participantsMelanoma and Skin Cancer Trials Limited

View Study Details

NCT07200830Recruiting

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

This randomized phase III trial examines whether lengthening the dosage interval in an adaptive manner for the prostate cancer drug lutetium 177 Lu PSMA RLT improves quality of life without decreasing...

Irvine, CAPHASE31,524 participantsAlliance for Clinical Trials in Oncology

View Study Details

NCT06952504Recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Researchers are looking for new ways to treat people with proficient mismatch repair (pMMR) endometrial cancer (EC) that is advanced or recurrent. * EC is a type of cancer that starts in the tissues ...

Irvine, CAPHASE31,123 participantsMerck Sharp & Dohme LLC

View Study Details

NCT05980949Recruiting

Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT and KarXT + KarX-EC in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

This is a Phase 3 global, multicenter, 52-week, open-label extension (OLE) rollover study for subjects completing study CN012-0026, CN012-0027, CN012-0056 or CN012-0034. Subjects (randomized or non-ra...

Irvine, CAPHASE31,000 participantsKaruna Therapeutics

View Study Details

NCT05354141Recruiting

Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)

To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitaliz...

Irvine, CAPHASE3970 participantsDirect Biologics, LLC

View Study Details

NCT07166094Recruiting

Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer

The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatm...

Irvine, CAPHASE3660 participantsGenmab

View Study Details

NCT06989112Recruiting

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when compared to chemotherapy (carboplatin + paclitaxel) + pembroliz...

Irvine, CAPHASE3600 participantsAstraZeneca

View Study Details

NCT06976203Recruiting

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease...

Irvine, CAPHASE3586 participantsBristol-Myers Squibb

View Study Details

NCT05511363Recruiting

A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)

This is a Phase 3, 38-week, randomized, double-blind, placebo-controlled, multicenter, outpatient study in subjects with psychosis associated with Alzheimer's Disease. The primary objective of the st...

Irvine, CAPHASE3410 participantsKaruna Therapeutics

View Study Details

NCT06545331Recruiting

Study of XB010 in Subjects With Solid Tumors

This is a FIH study is to evaluate the safety, tolerability, PK, immunogenicity, and preliminary antitumor activity of XB010 as a single agent and in combination with pembrolizumab in subjects with lo...

Irvine, CAPHASE1396 participantsExelixis

View Study Details

NCT07033494Recruiting

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memo...

Irvine, CAPHASE2340 participantsMerck Sharp & Dohme LLC

View Study Details

NCT07154290Recruiting

A Study to Investigate Ubamatamab With and Without REGN7075 in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

This study will evaluate two study drugs called ubamatamab and REGN7075, to see if they can help treat advanced or metastatic Non-Small Cell Lung Cancer (NSCLC), and sarilumab, to evaluate to see if i...

Irvine, CAPHASE2300 participantsRegeneron Pharmaceuticals

View Study Details

NCT03550391Recruiting

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. It is a one-day (or in some cases two day), out-patient procedure during which a high dose of radiation is delivered to s...

Irvine, CAPHASE3206 participantsCanadian Cancer Trials Group

View Study Details

NCT07029581Recruiting

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Multicenter, randomized, 6-week, double-blind, placebo-controlled, parallel-group, Phase 2 study in subjects with LBDP....

Irvine, CAPHASE2180 participantsACADIA Pharmaceuticals Inc.

View Study Details

NCT05877430Recruiting

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

Study CJB-101-01 will be conducted at multiple centers in the USA and Republic of Korea as an open-label safety and preliminary efficacy study of CJRB-101 in combination with pembrolizumab in subjects...

Irvine, CAPHASE1160 participantsCJ Bioscience, Inc.

View Study Details

NCT05136196Recruiting

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

This phase II trial studies the good and bad effects of the combination of drugs called cabozantinib and nivolumab in treating patients with melanoma or squamous cell head and neck cancer that may hav...

Irvine, CAPHASE2150 participantsNational Cancer Institute (NCI)

View Study Details

NCT07581184Recruiting

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

This is a Phase 1b, multi-center, open-label study to evaluate the safety, tolerability, dosimetry, and pharmacokinetics (PK) of \[64Cu\]Cu-AKY-2519 and/or \[225Ac\]Ac-AKY-2519, as well as the prelimi...

Irvine, CAPHASE1138 participantsAktis Oncology, Inc.

View Study Details

NCT06524973Recruiting

Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

This clinical trial evaluates the impact of telehealth self-management coaching sessions on quality of life in pancreatic cancer survivors and their family care givers (FCGs). Patients with pancreatic...

Irvine, CANA136 participantsCity of Hope Medical Center

View Study Details

NCT03739814Recruiting

Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia

This phase II trial studies how well inotuzumab ozogamicin and blinatumomab with or without ponatinib work in treating patients with CD22-positive B-lineage acute lymphoblastic leukemia that is newly ...

Irvine, CAPHASE284 participantsNational Cancer Institute (NCI)

View Study Details

NCT05551793Recruiting

Regeneron AA Multicenter (Dupilumab)

This is a prospective, randomized, double blind, placebo-controlled clinical trial. The study will take place at 4 sites. This trial will enroll a total of 68 patients with moderate to severe AA (affe...

Irvine, CAPHASE276 participantsEmma Guttman

View Study Details

NCT06577441Recruiting

Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

This phase II MyeloMATCH treatment trial compares the usual treatment of cedazuridine-decitabine (ASTX727) to the combination treatment of ASTX727 and enasidenib in treating patients with higher-risk,...

Irvine, CAPHASE254 participantsNational Cancer Institute (NCI)

View Study Details

NCT06492122Recruiting

Study With [225Ac]Ac-FL-020 in mCRPC Participants

The purpose of this study is to evaluate the safety, therapeutic effect, and pharmacokinetics of \[225Ac\]Ac-FL-020 in participants with metastatic castration-resistant prostate cancer (mCRPC)....

Irvine, CAPHASE150 participantsFull-Life Technologies UK Limited

View Study Details

NCT07156227Recruiting

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

This phase I trial tests the safety, side effects, and best dose of camonsertib in combination with stereotactic body radiation therapy in controlling disease in patients with head and neck squamous c...

Irvine, CAPHASE139 participantsNational Cancer Institute (NCI)

View Study Details

NCT06654037Recruiting

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

This phase I trial tests the safety, side effects, and best dose of abemaciclib in combination with 5-fluorouracil and how well it works in treating patients with colorectal cancer that has spread fro...

Irvine, CAPHASE139 participantsNational Cancer Institute (NCI)

View Study Details

NCT06910761Recruiting

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

This phase II trial tests how well craniospinal irradiation (CSI) using photon volumetric modulated arc radiotherapy (VMAT) works in treating patients with breast cancer or non-small cell lung cancer ...

Irvine, CAPHASE235 participantsCity of Hope Medical Center

View Study Details

NCT06439836Recruiting

Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy

This phase I trial tests the safety, side effects, best dose, and effectiveness of emavusertib (CA-4948) in combination with pembrolizumab in treating patients with urothelial cancer that has spread f...

Irvine, CAPHASE127 participantsNational Cancer Institute (NCI)

View Study Details

About Myalgic Encephalomyelitis Clinical Trials in Irvine

Myalgic encephalomyelitis (ME/CFS) is a complex, chronic illness characterized by profound fatigue, post-exertional malaise, cognitive impairment, and sleep dysfunction. It affects millions worldwide and has no definitive diagnostic test or cure. Research is exploring immune, metabolic, and neurological mechanisms.

There are currently 27 myalgic encephalomyelitis clinical trials recruiting participants in Irvine, CA. These studies are seeking a combined 92,281 participants. Research is being sponsored by Hoffmann-La Roche, Melanoma and Skin Cancer Trials Limited, Alliance for Clinical Trials in Oncology and 16 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Myalgic Encephalomyelitis Clinical Trials in Irvine — FAQ

Are there myalgic encephalomyelitis clinical trials in Irvine?

Yes, there are 27 myalgic encephalomyelitis clinical trials currently recruiting in Irvine, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Irvine?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Irvine research site will contact you about next steps.

Are clinical trials in Irvine free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Irvine studies also compensate for your time and travel.

What myalgic encephalomyelitis treatments are being tested?

The 27 active trials in Irvine are testing new therapies including novel drugs, biologics, and treatment approaches for myalgic encephalomyelitis.

Data updated October 18, 2026 from ClinicalTrials.gov