12 Heart Disease Clinical Trials in Jacksonville, NC (2026)

Q: How do I join a clinical trial in Jacksonville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Jacksonville research site will contact you.

Recruiting Heart Disease Studies in Jacksonville

NCT06271590Recruiting

MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

This is a multicenter, randomized, single-blind pivotal study to evaluate the safety and efficacy of the MagicTouchTM Drug coated balloon in treatment of small vessels in patients with coronary artery...

Jacksonville, NC1,605 participantsConcept Medical Inc.

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NCT05332262Recruiting

A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction

Despite the relative safety of PCI with new generation stents, peri-PCI thrombotic complications, including myocardial infarction and myocardial injury, are common in elective PCI, occurring in up to ...

Jacksonville, NC500 participantsUniversity of Florida

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NCT07293260Recruiting

Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial

The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA)....

Jacksonville, NC406 participantsAmgen

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NCT06813911Recruiting

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

The purpose of the study CTQJ230A12304, is to evaluate the efficacy, safety, and tolerability of pelacarsen (TQJ230) compared to placebo in participants with ASCVD who have elevated lipoprotein(a) (Lp...

Jacksonville, NC340 participantsNovartis Pharmaceuticals

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NCT06445608Recruiting

PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk PCI procedure....

Jacksonville, NC310 participantsKardion Inc

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NCT05681702Recruiting

Tailoring Bleeding Reduction Approaches in Patients Undergoing PCI

Two strategies have both proven to be effective in reducing bleeding complications while preserving efficacy compared with maintaining long-term DAPT with aspirin and a potent P2Y12 inhibitor: a) DAPT...

Jacksonville, NC90 participantsUniversity of Florida

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NCT06588595Recruiting

The Switching Antiplatelet-9 (SWAP-9) Study

The purpose of this study is to compare the pharmacodynamic effects of ABCD-GENE guided vs. unguided de-escalation strategies among patients on dual antiplatelet therapy (DAPT) following percutaneous ...

Jacksonville, NC90 participantsUniversity of Florida

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NCT06821191Recruiting

Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study

Dual antiplatelet therapy (DAPT) with low-dose aspirin and a P2Y12 inhibitor is the current standard of care in patients with coronary artery disease experiencing an acute event or undergoing percutan...

Jacksonville, NC78 participantsUniversity of Florida

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NCT07225842Recruiting

The Bridging Antiplatelet Therapy With Cangrelor 2 Study

The primary aim of this study is to determine rates of patients with optimal platelet reactivity range, defined as PRU levels between 85 and 208, when using a (PFT)-guided titration of cangrelor infus...

Jacksonville, NC50 participantsUniversity of Florida

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NCT06228456Recruiting

Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention

The proposed study aims to assess the antiplatelet effects of more potent oral P2Y12 inhibition with low-dose ticagrelor (60 mg bid) compared with standard of care clopidogrel in patients with a high ...

Jacksonville, NC50 participantsUniversity of Florida

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NCT06691191Recruiting

Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors

Ticagrelor currently represents the most tested and commonly used P2Y12 inhibitor monotherapy following percutaneous coronary intervention. The purpose of this study is to conduct a head-to-head compa...

Jacksonville, NC48 participantsUniversity of Florida

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NCT07025148Recruiting

Dual Antiplatelet Therapy Escalation From Standard-dose Clopidogrel to Low-Dose Prasugrel in Patients With High Bleeding and Ischemic Risk Undergoing PCI: A Prospective, Randomized Pharmacodynamic Study (TAILOR-BLEED-2)

The primary aim of this study is to investigate the PD effects of switching from standard-dose clopidogrel dose to low-dose prasugrel versus continuing standard-dose clopidogrel in patients at dual-ri...

Jacksonville, NC40 participantsUniversity of Florida

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About Heart Disease Clinical Trials in Jacksonville

Heart disease is the leading cause of death worldwide, encompassing conditions that affect the heart and blood vessels. Coronary artery disease, the most common type, occurs when arteries supplying the heart become narrowed or blocked. Risk factors include high blood pressure, high cholesterol, diabetes, and smoking.

There are currently 12 heart disease clinical trials recruiting participants in Jacksonville, NC. These studies are seeking a combined 3,607 participants. Research is being sponsored by Concept Medical Inc., University of Florida, Amgen and 2 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Heart Disease Clinical Trials in Jacksonville — FAQ

Are there heart disease clinical trials in Jacksonville?

Yes, there are 12 heart disease clinical trials currently recruiting in Jacksonville, NC. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Jacksonville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Jacksonville research site will contact you about next steps.

Are clinical trials in Jacksonville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Jacksonville studies also compensate for your time and travel.

What heart disease treatments are being tested?

The 12 active trials in Jacksonville are testing new therapies including novel drugs, biologics, and treatment approaches for heart disease.

Data updated July 13, 2026 from ClinicalTrials.gov