20 Lung Cancer Clinical Trials in Lexington, MA (2026)

Q: How do I join a clinical trial in Lexington?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Lexington research site will contact you.

Recruiting Lung Cancer Studies in Lexington

NCT07682610Recruiting

Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Health Services Research Intervention

This clinical trial studies statewide optimization of lung cancer screening (LCS) in Kentucky using the Quality Implementation of Lung Screening (QUILS™) System. Data from the Kentucky Cancer Registry...

Lexington, MA35,500 participantsTimothy Mullett

View Study Details

NCT05456841Recruiting

Empathic Communication Skills (ECS) Training

Research indicates that perceived stigma within medical encounters is prevalent and problematic for lung cancer patients' well-being and quality of cancer care. Promoting empathic communication appear...

Lexington, MA1,232 participantsMemorial Sloan Kettering Cancer Center

View Study Details

NCT06236438Recruiting

Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Non-Squamous Non-Small Cell Lung Cancer (NSCLC) remains a leading cause of cancer mortality worldwide, with poor survival prospects for metastatic disease. The purpose of this study is to evaluate the...

Lexington, MA840 participantsAbbVie

View Study Details

NCT06203210Recruiting

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

This study was designed to compare the efficacy and safety of I-DXd with treatment of physician's choice in participants with relapsed small cell lung cancer (SCLC)....

Lexington, MA540 participantsDaiichi Sankyo

View Study Details

NCT04165070Recruiting

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) with or without chemotherapy in combination with vibostolimab (MK-7684), boserolimab (MK-5890), MK-4830, MK-04...

Lexington, MA450 participantsMerck Sharp & Dohme LLC

View Study Details

NCT07639255Recruiting

Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Implementation

This is an optimization pathway for lung cancer screening programs. Enrolled programs will undergo an audit for elements associated with improved quality and retention of patients in the screening pro...

Lexington, MA330 participantsTimothy Mullett

View Study Details

NCT05142189Recruiting

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

This first-in-human (FIH) study for BNT116 aims to establish the safety profile and a safe dose for BNT116 monotherapy as well as for BNT116 in combination with approved medicinal products and/or in c...

Lexington, MA320 participantsBioNTech SE

View Study Details

NCT05857995Recruiting

Precision Lung Cancer Survivorship Care Intervention

The overarching goal of the Kentucky LEADS Collaborative Lung Cancer Survivorship Care program is to reduce the burden of lung cancer by offering an innovative survivorship care approach that improves...

Lexington, MA300 participantsJerod L Stapleton, PhD

View Study Details

NCT02468024Recruiting

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

To Determine if SAbR improves survival over SR in High Risk Operable Stage I NSCLC...

Lexington, MA272 participantsUniversity of Texas Southwestern Medical Center

View Study Details

NCT06047301Recruiting

Pathways, a Hope Intervention to Support Personal Goal Pursuit, Mental Health, and Quality of Life During Advanced Lung Cancer Treatment

This study will compare the effects of a brief supportive intervention, called Pathways, against enhanced usual care on the mental health and quality of life of people undergoing treatment for advance...

Lexington, MA234 participantsLaurie McLouth

View Study Details

NCT04077099Recruiting

A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer

This study will evaluate REGN5093 for the treatment of Non-Small Cell Lung Cancer (NSCLC) with MET alteration. The main purpose of this study is to determine the safety, tolerability, and effectivenes...

Lexington, MA231 participantsRegeneron Pharmaceuticals

View Study Details

NCT05882058Recruiting

DAREON™-5: A Study to Test Whether Different Doses of BI 764532 Help People With Small Cell Lung Cancer or Other Neuroendocrine Cancers

This study is open to adults with small cell lung cancer and other neuroendocrine tumours. The study is in people with advanced cancer for whom previous treatment was not successful or no standard tre...

Lexington, MA204 participantsBoehringer Ingelheim

View Study Details

NCT07155174Recruiting

A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer

Small cell lung cancer (SCLC) is characterized by aggressive and rapid growth and a tendency to develop early spread to distant sites including mediastinal lymph nodes, liver, bones, adrenal glands, a...

Lexington, MA180 participantsAbbVie

View Study Details

NCT04486833Recruiting

Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib

The purpose of this randomized study is to determine the safety and efficacy of quaratusugene ozeplasmid (Reqorsa) added to osimertinib in NSCLC patients with activating EGFR mutations who have progre...

Lexington, MA158 participantsGenprex, Inc.

View Study Details

NCT06780098Recruiting

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

Researchers are looking for other ways to treat metastatic squamous non-small cell lung cancer (NSCLC). Squamous NSCLC is cancer that starts in squamous cells, which are flat cells that line the insid...

Lexington, MA144 participantsMerck Sharp & Dohme LLC

View Study Details

NCT06644768Recruiting

A Study of Valemetostat Tosylate Plus Pembrolizumab Versus Pembrolizumab Alone in First-Line NSCLC Without Actionable Genomic Alterations

This study will compare Valemetostat Tosylate Plus Pembrolizumab vs Pembrolizumab Alone in First-line NSCLC Without Actionable Genomic Alterations...

Lexington, MA137 participantsDaiichi Sankyo

View Study Details

NCT06780085Recruiting

A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)

Researchers are looking for new ways to treat metastatic nonsquamous non-small cell lung cancer (NSCLC) that has been treated before. Metastatic means the cancer has spread to other parts of the body....

Lexington, MA96 participantsMerck Sharp & Dohme LLC

View Study Details

NCT06731907Recruiting

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical rem...

Lexington, MA90 participantsMerck Sharp & Dohme LLC

View Study Details

NCT07564401Recruiting

A Study to Evaluate DJI136, a DLL3-targeted CAR-T Therapy

This is a Phase I/II, open-label, non-randomized, multi-center study in patients with extensive-stage small cell lung cancer (ES-SCLC) to determine the recommended dose(s) (RD) and to evaluate the saf...

Lexington, MA80 participantsNovartis Pharmaceuticals

View Study Details

NCT06592638Recruiting

A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

This is a multi-center, open-label, Phase 1 clinical study of ZG006 in the US for the treatment of subjects with small cell lung cancer who have failed or are intolerant to available standard treatmen...

Lexington, MA30 participantsSuzhou Zelgen Biopharmaceuticals Co.,Ltd

View Study Details

About Lung Cancer Clinical Trials in Lexington

Lung cancer is the leading cause of cancer death worldwide, starting in the cells of the lungs. The two main types are non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Treatments include surgery, chemotherapy, radiation, immunotherapy, and targeted drugs.

There are currently 20 lung cancer clinical trials recruiting participants in Lexington, MA. These studies are seeking a combined 41,368 participants. Research is being sponsored by Timothy Mullett, Memorial Sloan Kettering Cancer Center, AbbVie and 11 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Lung Cancer Clinical Trials in Lexington — FAQ

Are there lung cancer clinical trials in Lexington?

Yes, there are 20 lung cancer clinical trials currently recruiting in Lexington, MA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Lexington?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Lexington research site will contact you about next steps.

Are clinical trials in Lexington free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Lexington studies also compensate for your time and travel.

What lung cancer treatments are being tested?

The 20 active trials in Lexington are testing new therapies including novel drugs, biologics, and treatment approaches for lung cancer.

Data updated July 13, 2026 from ClinicalTrials.gov