Los Angeles, CALIFORNIA7 Active Studies

Diffuse Large B-Cell Lymphoma Clinical Trials in Los Angeles, CALIFORNIA

Find 7 actively recruiting diffuse large b-cell lymphoma clinical trials in Los Angeles, CALIFORNIA. Connect with local research sites and explore new treatment options.

7
Active Trials
6
Sponsors
3,210
Enrolling

Recruiting Diffuse Large B-Cell Lymphoma Studies in Los Angeles

RecruitingLos Angeles, CALIFORNIANCT06047080

An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma

The purpose of this study is to compare the efficacy and safety of glofitamab in combination with polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisone (Pola-R-CHP) vs Pola...

1,130 participants
Hoffmann-La Roche
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RecruitingLos Angeles, CALIFORNIANCT06717347

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment ...

1,046 participants
Merck Sharp & Dohme LLC
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RecruitingLos Angeles, CALIFORNIANCT06508658

A Study of Subcutaneously Injected Epcoritamab Plus Oral Lenalidomide Tablets Compared to Intravenously (IV) Infused Rituximab Plus IV Infused Gemcitabine and IV Infused Oxaliplatin in Adult Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

B-cell Lymphoma is an aggressive and rare cancer of a type of immune cells (a white blood cell responsible for fighting infections). This study will assess how safe and effective epcoritamab plus lena...

360 participants
Genmab
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RecruitingLos Angeles, CALIFORNIANCT05605899

Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma

The goal of this clinical study is to compare the study drug, axicabtagene ciloleucel, versus standard of care (SOC) in first-line therapy in participants with high-risk large B-cell lymphoma....

300 participants
Kite, A Gilead Company
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RecruitingLos Angeles, CALIFORNIANCT06500273

Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

This is a randomized, open-label study in adult patients who have completed standard first line therapy for large B-cell lymphoma (LBCL) and achieved a complete response or partial response suitable f...

250 participants
Allogene Therapeutics
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RecruitingLos Angeles, CALIFORNIANCT06806033

A Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma

The main goal of this trial is to study the frequency and severity of cytokine release syndrome (CRS) in participants with diffuse large B-cell lymphoma (DLBCL) who are using a combination of glofitam...

100 participants
Hoffmann-La Roche
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RecruitingLos Angeles, CALIFORNIANCT05256641

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

This phase Ib/II trial studies the side effects and efficacy of maintenance acalabrutinib following cellular therapy in treating patients with large B-cell lymphoma at very high risk of the cancer com...

24 participants
Jonsson Comprehensive Cancer Center
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About Diffuse Large B-Cell Lymphoma Clinical Trials in Los Angeles

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, accounting for about 30% of cases. It is an aggressive lymphoma that grows rapidly. Treatment usually involves chemoimmunotherapy, with CAR-T cell therapy for relapsed cases.

There are currently 7 diffuse large b-cell lymphoma clinical trials recruiting participants in Los Angeles, CALIFORNIA. These studies are seeking a combined 3,210 participants. Research is being sponsored by Hoffmann-La Roche, Merck Sharp & Dohme LLC, Genmab and 3 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Diffuse Large B-Cell Lymphoma Clinical Trials in Los Angeles — FAQ

Are there diffuse large b-cell lymphoma clinical trials in Los Angeles?

Yes, there are 7 diffuse large b-cell lymphoma clinical trials currently recruiting in Los Angeles, CALIFORNIA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Los Angeles?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Los Angeles research site will contact you about next steps.

Are clinical trials in Los Angeles free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Los Angeles studies also compensate for your time and travel.

What diffuse large b-cell lymphoma treatments are being tested?

The 7 active trials in Los Angeles are testing new therapies including novel drugs, biologics, and treatment approaches for diffuse large b-cell lymphoma.

Data updated March 2, 2026 from ClinicalTrials.gov