38 Myalgic Encephalomyelitis Clinical Trials in Nashville, TN (2026)

Q: How do I join a clinical trial in Nashville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Nashville research site will contact you.

Recruiting Myalgic Encephalomyelitis Studies in Nashville

NCT01376024Recruiting

Study on Basal Joint Arthritis Prospective

The data in this prospective registry will be used 1) to define which surgical and nonoperative techniques are most effective at providing pain relief, restoring function, are cost effective, and pati...

Nashville, TN800 participantsColumbia University

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NCT07066657Recruiting

A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors

This is an open-label, multi-center, phase I study to evaluate the safety, tolerability, efficacy, and pharmacokinetics of MRG007 (ARR-217) in patients with unresectable locally advanced or metastatic...

Nashville, TNPHASE1572 participantsArriVent BioPharma, Inc.

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NCT07146516Recruiting

Retinal Detachment Prevention (Laser Prophylaxis) in Stickler Syndrome (SS)

The goal of this clinical trial is to prospectively document to what extent the OSC/SS prophylactic laser retinopexy procedure works to prevent retinal detachment in SS in children and adults. Resear...

Nashville, TNNA500 participantsHelen Keller Eye Research Foundation

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NCT07287995Recruiting

A Study of ASP2998 Given by Itself and Given With Standard Therapies in People With Solid Tumors

Specific proteins found in tumors help the tumors spread and grow. People with solid tumors often have a protein called TROP2 in their tumor. ASP2998 is being developed to attach to TROP2 and then att...

Nashville, TNPHASE1428 participantsAstellas Pharma Global Development, Inc.

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NCT06713616Recruiting

PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

The purpose of this study is to compare the relative effectiveness, acceptability, and side effects of ketamine delivered through an IV (a drip into the arm) which is not currently FDA approved for us...

Nashville, TNPHASE3400 participantsYale University

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NCT06752681Recruiting

To Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of DAY301 in Participants With Locally Advanced or Metastatic Solid Tumors

This is a Phase 1a/1b, open-label, dose escalation and expansion study to evaluate the safety and anti-tumor activity of DAY301, a PTK7-directed antibody-drug conjugate in participants with advanced o...

Nashville, TNPHASE1300 participantsDay One Biopharmaceuticals, Inc.

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NCT07229430Recruiting

Safety and Effectiveness Evaluation of the High-intensity Focused Ultrasound Device for Lifting Lax Submental and Neck Tissue

This is a prospective, multicenter, randomized, evaluator-blinded, parallel-controlled, non-inferiority clinical study designed to evaluate the safety and effectiveness of the ULTRAFORMER MPT PLUS, a ...

Nashville, TNNA273 participantsCLASSYS Inc.

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NCT03851484Recruiting

Sensory Symptoms in Tourette Syndrome

Patients with tics will be asked to complete a series of validated questionnaires (in electronic and/or paper format) regarding symptoms and conditions often associated with Tourette syndrome, includi...

Nashville, TN214 participantsVanderbilt University Medical Center

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NCT05932589Recruiting

Neurophysiologic Biomarkers in Rett Syndrome

The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: * Do these biomarkers change during clinica...

Nashville, TN202 participantsChildren's Hospital of Philadelphia

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NCT07021898Recruiting

A Study of ERAS-4001 in Patients With Advanced or Metastatic Solid Tumors.

The main purpose of the study is to assess whether the study drug, ERAS-4001, is safe and tolerable when administered to patients with advanced or metastatic solid tumors with certain KRAS mutations. ...

Nashville, TNPHASE1200 participantsErasca, Inc.

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NCT07524855Recruiting

A Study of HLD-0117 in Patients With Metastatic Breast Cancer

Assessment of the safety and efficacy of HLD-0117 as monotherapy in patients with estrogen receptor positive (ER+) metastatic breast cancer (MBC) or locally advanced breast cancer that have progressed...

Nashville, TNPHASE1170 participantsHalda Therapeutics OpCo, Inc.

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NCT05770531Recruiting

Circulating Tumor DNA to Guide Changes in Standard of Care Chemotherapy

This phase II trial tests how well evaluating circulating tumor deoxyribonucleic acid (ctDNA) works to guide therapy-change decisions in treating patients with triple-negative breast cancer (TNBC) tha...

Nashville, TNPHASE2160 participantsVanderbilt-Ingram Cancer Center

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NCT05267626Recruiting

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

This is a first in human, open-label, multi-center Phase 1 / 2 study to evaluate the safety, tolerability, and initial efficacy of AU-007 in patients with advanced solid tumors. AU-007 will be adminis...

Nashville, TNPHASE1159 participantsAulos Bioscience, Inc.

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NCT03328650Recruiting

Clinical Outcomes of the ALPS Proximal Humerus Plating System

The purpose of this study is to document the performance and clinical outcomes of the A.L.P.S® Proximal Humerus Plating System. Specific Aims: * Conduct physical assessments measuring shoulder stren...

Nashville, TN150 participantsVanderbilt University Medical Center

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NCT06414460Recruiting

Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors

The study has consists of two parts, a dose escalation part (Part 1) and a dose selection optimization part (Part 2). The primary objectives of this study are to evaluate the safety and tolerability o...

Nashville, TNPHASE1146 participantsInSilico Medicine Hong Kong Limited

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NCT04851678Recruiting

Longitudinal Impact of Stressors in Adults With Tourette Syndrome

The Investigators propose a two-year, longitudinal pilot study of TS adults (\>18) to determine impact of lifetime environmental stress exposure on tic severity, psychiatric comorbidity severity, and ...

Nashville, TN140 participantsVanderbilt University Medical Center

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NCT06055439Recruiting

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

The goal of this clinical trial is to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least ...

Nashville, TNPHASE1135 participantsChimeric Therapeutics

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NCT05334368Recruiting

Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety Trial

This is a 52-week, randomized, placebo-controlled, double-blind, parallel group, multicenter study of depemokimab in adults with uncontrolled HES receiving standard of care (SoC) therapy. The study w...

Nashville, TNPHASE3109 participantsGlaxoSmithKline

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NCT06566079Recruiting

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

This is a Phase 1, open-label, multicenter, FIH study to evaluate the safety, tolerability, recommended Phase 2 dose (RP2D), PK/PD, and preliminary anti-tumor activity of ISM6331 in participants with ...

Nashville, TNPHASE1100 participantsInSilico Medicine Hong Kong Limited

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NCT07197944Recruiting

Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS

The purpose of the present Phase 3 trial is to confirm the efficacy and safety of glepaglutide 10 mg twice weekly in a patient population with SBS-IF and generate additional long-term safety data. Gl...

Nashville, TNPHASE390 participantsZealand Pharma

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NCT07015697Recruiting

A Study of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

This dose escalation and dose expansion study was designed to assess the safety, tolerability, PK and efficacy of subcutaneous T-DXd in participants with metastatic solid tumors....

Nashville, TNPHASE176 participantsDaiichi Sankyo

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NCT06994676Recruiting

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

Study CBX-250-001 is a Phase 1, open-label, dose-escalation study of CBX-250 in participants with relapsed/refractory AML, HR-MDS, CMML, and CML. Participants aged ≥ 12 years are planned to be enrolle...

Nashville, TNPHASE172 participantsCrossbow Therapeutics, Inc.

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NCT07142252Recruiting

Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus

This Phase 2 study is a 2-arm, multi-center, double-masked (masking of the participant, care provider and investigator), placebo-controlled, 2:1 randomized trial design in new onset T1D participants (...

Nashville, TNPHASE266 participantsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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NCT05187832Recruiting

A Study of AND019 in Women With ER Positive HER2 Negative Advanced or Metastatic Breast Cancer

This is a first in human dose escalation and expansion study to evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD) activity, and preliminary anti-tumor activity of AND019 in...

Nashville, TNPHASE161 participantsKind Pharmaceuticals LLC

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NCT07140900Recruiting

Study Evaluating the Safety, Tolerability, and Efficacy of Xaluritamig in Combination With Androgen Receptor Pathway Inhibitors in Participants With Metastatic Hormone-sensitive Prostate Cancer

The main objective of the trial is to evaluate the safety and tolerability of xaluritamig in combination with darolutamide or abiraterone....

Nashville, TNPHASE160 participantsAmgen

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NCT07189936Recruiting

Effect of 2-HOBA in Persistent Immune Activation in Long COVID POTS

Long COVID is defined by a range of symptoms affecting multiple organs that persist for more than three months following an acute SARS-CoV-2 infection. Approximately 7% of individuals who recover from...

Nashville, TNPHASE250 participantsVanderbilt University Medical Center

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NCT06430385Recruiting

ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)

The primary purpose of this study is to evaluate the safety and tolerability of ION440....

Nashville, TNPHASE148 participantsIonis Pharmaceuticals, Inc.

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NCT06940739Recruiting

A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel

A Phase 1/2, open-label study of a modified interleukin-2 fusion protein (IOV 3001) in participants with previously treated, unresectable or metastatic melanoma who will receive lifileucel....

Nashville, TNPHASE142 participantsIovance Biotherapeutics, Inc.

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NCT05431270Recruiting

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

This is a first-in-human, Phase 1/2, open-label, study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Mavrostobart (PT199) alone and in ...

Nashville, TNPHASE140 participantsPhanes Therapeutics

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NCT07493512Recruiting

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

The primary objective of this trial is to determine the safety profile of xaluritamig at the proposed regimen in adult participants with metastatic castration-resistant prostate cancer (mCRPC)....

Nashville, TNPHASE140 participantsAmgen

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NCT07136181Recruiting

Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma

This study is being done to find the best dose of an investigational drug called NBM-BMX for people with metastatic uveal melanoma, a type of eye cancer that has spread to other parts of the body. Th...

Nashville, TNPHASE136 participantsNovelwise Pharmaceutical Corporation

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NCT07584226Recruiting

A First-in-human Study of RLY-8161 in Advanced NRAS-Mutant Solid Tumors

This is a Phase 1 first-in-human, open-label multicenter study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of RLY-8161, a...

Nashville, TNPHASE135 participantsRelay Therapeutics, Inc.

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NCT07493447Recruiting

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

This pilot clinical study evaluates the safety and imaging performance of panitumumab-IRDye800 (pan800), a fluorescent, EGFR-targeted imaging agent - in patients undergoing neurosurgical resection of ...

Nashville, TNEARLY_PHASE130 participantsEben Rosenthal

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NCT07156318Recruiting

Drumming Lessons' Influence on Children With Down Syndrome

The goal of this clinical trial is to learn if drumming lessons can increase self-control in children with Down syndrome. The main question it aims to answer is whether 2 months of drumming lessons ca...

Nashville, TNNA30 participantsVanderbilt University

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NCT06643884Recruiting

Suprachoroidal Administration in Subjects With Choroidal Metastasis From Breast or Lung Primary Tumors

The primary objective is to assess the safety and tolerability of bel-sar treatment in subjects with choroidal metastasis from breast or lung primary tumors....

Nashville, TNPHASE224 participantsAura Biosciences

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NCT05425004Recruiting

Cabozantinib for Patients With Recurrent or Progressive Meningioma

A Phase II Study of Cabozantinib for Patients with Recurrent or Progressive Meningioma...

Nashville, TNPHASE224 participantsBaptist Health South Florida

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NCT06064890Recruiting

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)

The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called Frontotemporal Dementia with Progranulin Mutations...

Nashville, TNPHASE118 participantsAviadoBio Ltd

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NCT07197905Recruiting

Restoring Iron Deficiency in POTS

People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body). The purpose of this pilot stu...

Nashville, TNPHASE212 participantsVanderbilt University Medical Center

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About Myalgic Encephalomyelitis Clinical Trials in Nashville

Myalgic encephalomyelitis (ME/CFS) is a complex, chronic illness characterized by profound fatigue, post-exertional malaise, cognitive impairment, and sleep dysfunction. It affects millions worldwide and has no definitive diagnostic test or cure. Research is exploring immune, metabolic, and neurological mechanisms.

There are currently 38 myalgic encephalomyelitis clinical trials recruiting participants in Nashville, TN. These studies are seeking a combined 6,012 participants. Research is being sponsored by Columbia University, ArriVent BioPharma, Inc., Helen Keller Eye Research Foundation and 29 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Myalgic Encephalomyelitis Clinical Trials in Nashville — FAQ

Are there myalgic encephalomyelitis clinical trials in Nashville?

Yes, there are 38 myalgic encephalomyelitis clinical trials currently recruiting in Nashville, TN. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Nashville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Nashville research site will contact you about next steps.

Are clinical trials in Nashville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Nashville studies also compensate for your time and travel.

What myalgic encephalomyelitis treatments are being tested?

The 38 active trials in Nashville are testing new therapies including novel drugs, biologics, and treatment approaches for myalgic encephalomyelitis.

Data updated September 6, 2026 from ClinicalTrials.gov