29 Rheumatoid Arthritis Clinical Trials in Nashville, TX (2026)

Q: How do I join a clinical trial in Nashville?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Nashville research site will contact you.

Recruiting Rheumatoid Arthritis Studies in Nashville

NCT06226272Recruiting

Clinical Outcome Measure at Stryker Spine

This is a multicenter, prospective, retrospective, Post Market Clinical Follow-up (PMCF) study in subjects who have undergone or will undergo surgery utilizing one or more Stryker devices according to...

Nashville, TX5,222 participantsVB Spine, LLC

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NCT06080698Recruiting

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy f...

Nashville, TX1,030 participantsJohns Hopkins University

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NCT07006675Recruiting

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

Two arm, pragmatic, randomized controlled multicenter Phase III noninferiority trial evaluating the efficacy of standard pain management without NSAIDs (Group 1) vs. standard pain management plus up t...

Nashville, TX1,000 participantsMajor Extremity Trauma Research Consortium

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NCT05766670Recruiting

Intramedullary Calcium Sulfate Antibiotic Depot

The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients...

Nashville, TX497 participantsWake Forest University Health Sciences

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NCT05421741Recruiting

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treated with traditional standard of care intra...

Nashville, TX484 participantsWake Forest University Health Sciences

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NCT06201676Recruiting

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

The goal of this randomized clinical trial is to learn if the use of a low-dose nonsteroidal anti-inflammatory drug (NSAID), ketorolac, reduces the rate of chronic opioid use in orthopaedic polytrauma...

Nashville, TX458 participantsMassachusetts General Hospital

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NCT06293469Recruiting

Accelerated Flap Coverage in Severe Lower Extremity Trauma

The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with o...

Nashville, TX356 participantsJohns Hopkins University

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NCT06337292Recruiting

Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures

This is a multi-center, pragmatic, parallel arm randomized controlled trial (RCT) of 352 patients with high-risk open or closed tibial plateau fracture, high-risk open or closed tibial pilon fracture,...

Nashville, TX352 participantsMajor Extremity Trauma Research Consortium

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NCT05947071Recruiting

High vs.Standard Dose Influenza Vaccine in Pediatric Solid Organ Transplant (SOT) Recipients

Influenza virus is a significant pathogen in pediatric solid organ transplant (SOT) recipients. However, these individuals respond poorly to standard-dose (SD) inactivated influenza vaccine (IIV). Rec...

Nashville, TX312 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06013865Recruiting

Empagliflozin Treatment in Kidney Transplant Recipients

Kidney transplantation improves the health and quality of life for those Veterans with end stage kidney disease (ESKD). While early patient and graft survival are excellent, long-term outcomes continu...

Nashville, TX264 participantsVA Office of Research and Development

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NCT06393738Recruiting

A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma.

This clinical trial is studying the safety and potential anti-tumor activity of an investigational drug called ARV-393 in patients diagnosed with advanced Relapsed/Refractory non-Hodgkin's lymphoma (R...

Nashville, TX255 participantsArvinas Inc.

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NCT07325136Recruiting

A Study to Assess the Safety and Tolerability of BMS-986525 Alone and in Combination With Nivolumab in Participants With Relapsed/Refractory Small Cell Lung Cancer

The purpose of this study is to assess the safety and tolerability of BMS-986525 alone and in combination with Nivolumab in participants with Relapsed/Refractory Small Cell Lung Cancer...

Nashville, TX240 participantsBristol-Myers Squibb

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NCT06625073Recruiting

Randomized Trial of SGLT2i in Heart Transplant Recipients

Heart transplant (HTx) is an established therapy for advanced heart disease that restores quality of life and improves survival. However, due to preexisting comorbidities combined with the immunosuppr...

Nashville, TX200 participantsVA Office of Research and Development

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NCT06153251Recruiting

A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

The purpose of this study is to assess BMS-986453 in participants with relapsed and/or refractory multiple myeloma (RRMM)....

Nashville, TX187 participantsJuno Therapeutics, Inc., a Bristol-Myers Squibb Company

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NCT07144345Recruiting

Study of Reformulated Levulan Kerastick Plus PDT for Actinic Keratosis on Face and Scalp

This Phase 3, randomized, multi-center, evaluator-blind, vehicle-controlled study evaluates the efficacy and safety of reformulated Levulan Kerastick (aminolevulinic acid HCl 20%) combined with photod...

Nashville, TX160 participantsSun Pharmaceutical Industries, Inc.

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NCT03328650Recruiting

Clinical Outcomes of the ALPS Proximal Humerus Plating System

The purpose of this study is to document the performance and clinical outcomes of the A.L.P.S® Proximal Humerus Plating System. Specific Aims: * Conduct physical assessments measuring shoulder stren...

Nashville, TX150 participantsVanderbilt University Medical Center

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NCT06055439Recruiting

A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy

The goal of this clinical trial is to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least ...

Nashville, TX135 participantsChimeric Therapeutics

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NCT06047379Recruiting

Safety and Efficacy of NEO212 in Patients with Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 alone for the treatment of patients with ra...

Nashville, TX134 participantsNeonc Technologies, Inc.

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NCT05776069Recruiting

Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)

The VIVID study is structured in a master protocol format comprised of multiple parts that evaluate intravenous (IV) and subcutaneous (SC) VGA039 in healthy volunteers and subjects with von Willebrand...

Nashville, TX116 participantsVega Therapeutics, Inc

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NCT04146376Recruiting

Von Willebrand Factor in Pregnancy (VIP) Study

In pregnant women with von Willebrand disease (VWD) who by the third trimester do not have von Willebrand factor (VWF) or factor VIII (FVIII) levels greater than 50-100%, specific guidance is lacking ...

Nashville, TX110 participantsUniversity of Washington

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NCT07469891Recruiting

A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative Neoplasms

This is a first-in-human, open-label, multi-center Phase 1 study designed to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of PRT12396 in participants with high-risk po...

Nashville, TX100 participantsPrelude Therapeutics

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NCT06427538Recruiting

Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid...

Nashville, TX96 participantsVanderbilt University Medical Center

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NCT06895070Recruiting

XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

The purpose of this study is to evaluate if Non-Ischemic Heart Preservation (NIHP) of extended criteria donor hearts using the XVIVO Heart Preservation System (XHPS) is a safe and effective way to pre...

Nashville, TX60 participantsXVIVO Perfusion

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NCT07192458Recruiting

High vs. Standard Dose Influenza Vaccines in Lung Transplant (Repeater)

This will be a follow-up study to the "Comparison of High Dose vs. Standard Dose Influenza Vaccine in Lung Allograft Recipient" study (DMID Protocol Number 22-0014) at Vanderbilt University Medical Ce...

Nashville, TX60 participantsVanderbilt University Medical Center

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NCT07493512Recruiting

Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

The primary objective of this trial is to determine the safety profile of xaluritamig at the proposed regimen in adult participants with metastatic castration-resistant prostate cancer (mCRPC)....

Nashville, TX40 participantsAmgen

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NCT05734404Recruiting

Longitudinal Study for Central Nervous System Vasculitis

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech imp...

Nashville, TX40 participantsUniversity of Pennsylvania

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NCT06064890Recruiting

A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)

The goal of this clinical study is to learn about an investigational gene therapy product called AVB-101, which is designed to treat a disease called Frontotemporal Dementia with Progranulin Mutations...

Nashville, TX18 participantsAviadoBio Ltd

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NCT07197905Recruiting

Restoring Iron Deficiency in POTS

People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body). The purpose of this pilot stu...

Nashville, TX12 participantsVanderbilt University Medical Center

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NCT07145411Recruiting

HPC Offered for PRESERVE Expansion

Ossium recognizes that not all patients who could benefit from Ossium's HPC, Marrow can access the PRESERVE trial for logistical or eligibility reasons. The HOPE program is expanded access program to ...

Nashville, TX10 participantsOssium Health, Inc.

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About Rheumatoid Arthritis Clinical Trials in Nashville

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1.3 million Americans, where the immune system mistakenly attacks joint linings, causing painful swelling, bone erosion, and joint deformity. Early diagnosis and treatment are critical to prevent irreversible damage. Current standard treatments include methotrexate and other DMARDs, TNF inhibitors (etanercept, infliximab), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and JAK inhibitors (tofacitinib, baricitinib). Clinical trials are now exploring next-generation targeted therapies, dual-pathway inhibitors, and treatment strategies aimed at achieving sustained remission rather than just symptom control. Patients with inadequate response to conventional DMARDs or biologics are commonly eligible for enrollment.

There are currently 29 rheumatoid arthritis clinical trials recruiting participants in Nashville, TX. These studies are seeking a combined 12,098 participants. Research is being sponsored by VB Spine, LLC, Johns Hopkins University, Major Extremity Trauma Research Consortium and 19 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Rheumatoid Arthritis Clinical Trials in Nashville — FAQ

Are there rheumatoid arthritis clinical trials in Nashville?

Yes, there are 29 rheumatoid arthritis clinical trials currently recruiting in Nashville, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Nashville?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Nashville research site will contact you about next steps.

Are clinical trials in Nashville free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Nashville studies also compensate for your time and travel.

What rheumatoid arthritis treatments are being tested?

The 29 active trials in Nashville are testing new therapies including novel drugs, biologics, and treatment approaches for rheumatoid arthritis.

Data updated July 13, 2026 from ClinicalTrials.gov