11 Breast Cancer Clinical Trials in Newport Beach, CA (2026)

Q: How do I join a clinical trial in Newport Beach?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Newport Beach research site will contact you.

Recruiting Breast Cancer Studies in Newport Beach

NCT01042379Recruiting

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective with which types of breast cancer tumors and by learn...

Newport Beach, CAPHASE25,000 participantsQuantumLeap Healthcare Collaborative

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NCT06966700Recruiting

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

Researchers are looking for new ways to treat types of breast cancer that are both: * High-risk, which means the cancer may have a higher chance of getting worse or coming back after treatment * Earl...

Newport Beach, CAPHASE32,400 participantsMerck Sharp & Dohme LLC

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NCT07060807Recruiting

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Researchers are looking for other ways to treat breast cancer (BC) that is hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) and either unresectable locally a...

Newport Beach, CAPHASE31,000 participantsMerck Sharp & Dohme LLC

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NCT06380751Recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positiv...

Newport Beach, CAPHASE3788 participantsAstraZeneca

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NCT06926868Recruiting

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

The purpose of this study is to assess the efficacy and safety of iza-bren, a bi-specific antibody-drug conjugate against EGFR and HER3 with a topoisomerase inhibitor payload versus treatment of physi...

Newport Beach, CAPHASE2600 participantsBristol-Myers Squibb

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NCT06336928Recruiting

A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis

This study evaluates whether a special type of blood analysis, called liquid biopsy (LBx), correlates with mammography results and/or diagnosis of breast cancer....

Newport Beach, CA490 participantsUniversity of Southern California

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NCT06827236Recruiting

A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

This is a Phase I/II, multi-site, open-label, two-part study designed to evaluate the efficacy, safety, optimized dose and contribution of components of BNT323 in combination with BNT327 in participan...

Newport Beach, CAPHASE1380 participantsBioNTech SE

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NCT06993844Recruiting

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

Phase 1/2, open-label study of ETX-636 in participants with advanced solid tumors...

Newport Beach, CAPHASE1233 participantsEnsem Therapeutics

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NCT05872295Recruiting

IKS014 in Advanced Solid Tumors That Express HER2

This study will evaluate the recommended dose for further clinical development, safety, tolerability, anti-tumor activity, immunogenicity, pharmacokinetics and pharmacodynamics of IKS014, a HER2 targe...

Newport Beach, CAPHASE1165 participantsIksuda Therapeutics Ltd.

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NCT05372640Recruiting

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

This phase I trial tests the safety, side effects, and best dose of ZEN003694 when given together with abemaciclib in treating patients with NUT carcinoma, breast cancer or other solid tumors that hav...

Newport Beach, CAPHASE145 participantsNational Cancer Institute (NCI)

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NCT04049214Recruiting

Perioperative Mindfulness Proposal

The purpose of this study is to determine if a regular meditation and breath work practice started before surgery and continued through post-surgical recovery can improve anxiety and pain related to b...

Newport Beach, CANA24 participantsHoag Memorial Hospital Presbyterian

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About Breast Cancer Clinical Trials in Newport Beach

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 11 breast cancer clinical trials recruiting participants in Newport Beach, CA. These studies are seeking a combined 11,125 participants. Research is being sponsored by QuantumLeap Healthcare Collaborative, Merck Sharp & Dohme LLC, AstraZeneca and 7 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Newport Beach — FAQ

Are there breast cancer clinical trials in Newport Beach?

Yes, there are 11 breast cancer clinical trials currently recruiting in Newport Beach, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Newport Beach?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Newport Beach research site will contact you about next steps.

Are clinical trials in Newport Beach free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Newport Beach studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 11 active trials in Newport Beach are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated October 16, 2026 from ClinicalTrials.gov