12 Advanced Solid Tumors Clinical Trials in Oklahoma City, OK (2026)

Q: How do I join a clinical trial in Oklahoma City?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Oklahoma City research site will contact you.

Recruiting Advanced Solid Tumors Studies in Oklahoma City

NCT05932862Recruiting

A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors

This is a first-in-human (FIH), multicenter, open-label Phase I study to investigate the safety, tolerability, preliminary antitumor activity, as well as pharmacokinetics (PK) and pharmacodynamics of ...

Oklahoma City, OKPHASE1429 participantsExelixis

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NCT06545331Recruiting

Study of XB010 in Subjects With Solid Tumors

This is a FIH study is to evaluate the safety, tolerability, PK, immunogenicity, and preliminary antitumor activity of XB010 as a single agent and in combination with pembrolizumab in subjects with lo...

Oklahoma City, OKPHASE1396 participantsExelixis

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NCT05557045Recruiting

A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

This phase 1 study will investigate the safety, dosing, and initial antitumor activity of JZP815 in participants with advanced or metastatic solid tumors harboring alterations in the MAPK pathway....

Oklahoma City, OKPHASE1332 participantsJazz Pharmaceuticals

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NCT06004245Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

This is a first-in-human, Phase I, open-label, multicenter, dose-escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumo...

Oklahoma City, OKPHASE1280 participantsVividion Therapeutics, Inc.

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NCT06752681Recruiting

To Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of DAY301 in Participants With Locally Advanced or Metastatic Solid Tumors

This is a Phase 1a/1b, open-label, dose escalation and expansion study to evaluate the safety and anti-tumor activity of DAY301, a PTK7-directed antibody-drug conjugate in participants with advanced o...

Oklahoma City, OKPHASE1254 participantsDay One Biopharmaceuticals, Inc.

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NCT06459973Recruiting

A Clinical Study of YL205 in Patients With Advanced Solid Tumors

This study is a multicenter, open-label, phase I/II study of YL205 in China to evaluate the safety, tolerability, PK characteristics and preliminary efficacy of YL205 in the following selected patient...

Oklahoma City, OKPHASE1252 participantsMediLink Therapeutics (Suzhou) Co., Ltd.

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NCT06227377Recruiting

QTX3034 in Patients With KRAS G12D Mutation

Phase 1 study to determine the safety and tolerability of QTX3034 as a single agent or in combination with cetuximab....

Oklahoma City, OKPHASE1250 participantsQuanta Therapeutics

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NCT04219254Recruiting

A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors (KEYNOTE-A04)

Phase 1/2a Clinical Trial of BI-1206, a Monoclonal Antibody to CD32b (FcγRIIB), in Combination with Pembrolizumab in Subjects with Advanced Solid Tumors Previously Treated with Anti-PD-1 or Anti-PD-L1...

Oklahoma City, OKPHASE1197 participantsBioInvent International AB

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NCT06136884Recruiting

A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases

The purpose of this study is to assess the safety, tolerability and efficacy of the study drug AO-252 and identify the best dose for use in future studies....

Oklahoma City, OKPHASE186 participantsA2A Pharmaceuticals Inc.

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NCT06463340Recruiting

Study of SGR-3515 In Participants With Advanced Solid Tumors.

The purpose of this study is to learn about the effects of a new study drug, called SGR-3515 that may be a treatment for advanced solid tumors....

Oklahoma City, OKPHASE152 participantsSchrödinger, Inc.

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NCT04928508Recruiting

Advanced or Recurrent Solid Tumors Treated With SHetA2

The purpose of this research is to test the safety of the study drug (OK-1) and see what effects (good and bad) this drug has on patients with recurrent solid tumors....

Oklahoma City, OKPHASE150 participantsUniversity of Oklahoma

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NCT05431270Recruiting

Dose Escalation/Expansion Study of Mavrostobart (PT199), an Anti-CD73 MAb, Administered Alone and in Combination with a PD-1 Inhibitor or Chemotherapy (the MORNINGSTAR Study)

This is a first-in-human, Phase 1/2, open-label, study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Mavrostobart (PT199) alone and in ...

Oklahoma City, OKPHASE140 participantsPhanes Therapeutics

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About Advanced Solid Tumors Clinical Trials in Oklahoma City

Advanced solid tumors refer to cancers that have grown beyond the original site or spread to distant organs. Many clinical trials enroll patients with various types of advanced solid tumors to test novel therapies. These trials often investigate immunotherapy, targeted therapy, and combination approaches.

There are currently 12 advanced solid tumors clinical trials recruiting participants in Oklahoma City, OK. These studies are seeking a combined 2,618 participants. Research is being sponsored by Exelixis, Jazz Pharmaceuticals, Vividion Therapeutics, Inc. and 8 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Advanced Solid Tumors Clinical Trials in Oklahoma City — FAQ

Are there advanced solid tumors clinical trials in Oklahoma City?

Yes, there are 12 advanced solid tumors clinical trials currently recruiting in Oklahoma City, OK. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Oklahoma City?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Oklahoma City research site will contact you about next steps.

Are clinical trials in Oklahoma City free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Oklahoma City studies also compensate for your time and travel.

What advanced solid tumors treatments are being tested?

The 12 active trials in Oklahoma City are testing new therapies including novel drugs, biologics, and treatment approaches for advanced solid tumors.

Data updated July 18, 2026 from ClinicalTrials.gov