25 Geographic Atrophy Clinical Trials in Philadelphia, PA (2026)

Q: How do I join a clinical trial in Philadelphia?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you.

Recruiting Geographic Atrophy Studies in Philadelphia

NCT06080698Recruiting

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy f...

Philadelphia, PANA1,030 participantsJohns Hopkins University

View Study Details

NCT05880199Recruiting

BSGM to Evaluate Patients With GI Symptoms

The goal of this observational study is to learn about gastric myoelectric activity in children with GI symptoms. The main question it aims to answer is which patterns or signals are associated with G...

Philadelphia, PA685 participantsChildren's Hospital of Philadelphia

View Study Details

NCT01866371Recruiting

High Resolution Retinal Imaging

Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an adaptive optics...

Philadelphia, PA600 participantsUniversity of Pennsylvania

View Study Details

NCT07199517Recruiting

Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit

This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of t...

Philadelphia, PANA472 participantsAbramson Cancer Center at Penn Medicine

View Study Details

NCT06863168Recruiting

Cigarillo Public Education Messaging for Black Young Adults

This is a 3-arm randomized controlled trial to examine the effects of cigarillo public education messages among Black young adults who are at-risk for established cigarillo smoking. The primary outcom...

Philadelphia, PANA360 participantsDrexel University

View Study Details

NCT07218016Recruiting

Accelerometer Measured Early Recovery After Prolapse Surgery

The AccelERate study will evaluate the physical recovery of patients who have undergone Pelvic Organ Prolapse (POP) surgery. This will be evaluated via a self-reported recovery questionnaire completed...

Philadelphia, PANA288 participantsNICHD Pelvic Floor Disorders Network

View Study Details

NCT05846802Recruiting

Gastroparesis Registry 4

The Gastroparesis Registry 4 (GpR4) is an observational study of patients with symptoms of gastroparesis (Gp) and functional dyspepsia (FD) with either delayed or normal gastric emptying. To better un...

Philadelphia, PA250 participantsJohns Hopkins Bloomberg School of Public Health

View Study Details

NCT05683418Recruiting

A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

The goal of this clinical trial is to evaluate the safety and efficacy of TOS-358 in women with HR+ HER2- metastatic breast cancer whose tumors have a mutation in PIK3CA and who meet all other study e...

Philadelphia, PAPHASE1241 participantsTotus Medicines

View Study Details

NCT06372899Recruiting

Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After meas...

Philadelphia, PANA200 participantsAbramson Cancer Center at Penn Medicine

View Study Details

NCT04661215Recruiting

Pyloric Sphincter Abnormalities in Patients With Gastroparesis Symptoms

The overall objective of this study is to determine if there are pyloric sphincter abnormalities in patients with gastroparesis symptoms and determine how prevalent these abnormalities are using tests...

Philadelphia, PA150 participantsJohns Hopkins Bloomberg School of Public Health

View Study Details

NCT02753777Recruiting

Autoimmune Blistering Diseases Study

Pemphigus and bullous pemphigoid (BP) are severe autoimmune blistering diseases (AIBD) that pose a critical need for new therapeutic approaches. Clinical trials in pemphigus and BP will require the av...

Philadelphia, PA150 participantsUniversity of Pennsylvania

View Study Details

NCT06854120Recruiting

Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients: Baseline and Treatment Effects

Functional dyspepsia and gastroparesis are common stomach disorders with symptoms like early satiety, nausea, and abdominal pain, and are often evaluated with gastric emptying tests, although the corr...

Philadelphia, PA125 participantsUniversity of Auckland, New Zealand

View Study Details

NCT06930625Recruiting

A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs

The primary purpose of this study is to assess the effect of Debio 4126 in the maintenance of the levels of insulin-like growth factor 1 (IGF-1) ≤1x upper limit of normal (ULN) in the double-blind per...

Philadelphia, PAPHASE3119 participantsDebiopharm International SA

View Study Details

NCT03721822Recruiting

Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

The purpose of this research is to measure the extent of lung inflammation between different groups of participants using a radioactive tracer called \[18F\]NOS. A radioactive tracer is a type of imag...

Philadelphia, PAPHASE1100 participantsUniversity of Pennsylvania

View Study Details

NCT05957367Recruiting

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

This is a Phase 1/2, multicenter, open-label (unless otherwise specified in a combination-specific module) study of inlexisertib in combination with anticancer therapies. Modules within the master pro...

Philadelphia, PAPHASE194 participantsDeciphera Pharmaceuticals, LLC

View Study Details

NCT07425574Recruiting

A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults

Macular dystrophies are a group of inherited eye conditions that affect the macula. The macula is in the center of the retina, the light sensitive part at the back of the eye. In people with macular d...

Philadelphia, PA90 participantsAstellas Pharma Global Development, Inc.

View Study Details

NCT07282587Recruiting

Study of ONC206 (JZP3507) in Advanced Pheochromocytoma and Paraganglioma

This is a two-stage Phase 2 trial evaluating the efficacy and safety of ONC206 in participants with Pheochromocytoma and Paraganglioma (PCPG)....

Philadelphia, PAPHASE290 participantsJazz Pharmaceuticals

View Study Details

NCT06066957Recruiting

Open Label Trial of Oral Letermovir for CMV Prophylaxis in Thoracic Transplant Recipients

Open label study to determine tolerability and efficacy of letermovir for CMV prophylaxis in heart and lung transplant recipients. The study hypotheses are: 1. Letermovir prophylaxis will be associat...

Philadelphia, PAPHASE280 participantsUniversity of Pennsylvania

View Study Details

NCT06321536Recruiting

Response to Emerging Antimicrobial Resistance With Containment Microbiota Therapy (REACT)

REACT is a phase two, open-label, randomized, controlled trial of microbiota therapy (MT) to reduce colonization with multi-drug resistant organisms (MDRO). REACT is designed to assess the safety and ...

Philadelphia, PAPHASE260 participantsEmory University

View Study Details

NCT04434040Recruiting

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

The purpose of this study is to determine if a combination of two drugs sacituzumab govitecan and atezolizumab works as a treatment for residual cancer in the breast or lymph nodes and have circulatin...

Philadelphia, PAPHASE240 participantsDana-Farber Cancer Institute

View Study Details

NCT04422912Recruiting

A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

A phase 1/2, open-label, safety and dosing study of autologous CART cells (desmoglein 3 chimeric autoantibody receptor T cells \[DSG3-CAART\] or CD19-specific Chimeric Antigen Receptor T cells \[CABA-...

Philadelphia, PAPHASE140 participantsCabaletta Bio

View Study Details

NCT06994845Recruiting

Study to Assess the Efficacy, Pharmacokinetics, Safety and Tolerability of Iptacopan in Pediatric Patients With Primary IgAN

The study is an open-label, single arm, multicenter, Phase III study to determine proteinuria reduction, pharmacokinetics (PK), safety and tolerability (including CV surveillance) of iptacopan in prim...

Philadelphia, PAPHASE331 participantsNovartis Pharmaceuticals

View Study Details

NCT07211386Recruiting

The Erector Spinae Plane Block For Gastrointestinal Malignancy Pain Treatment (EGIPT)

This study will target patients with gastrointestinal (GI) malignancy who present to any of 4 Penn Medicine emergency departments (EDs) with intractable abdominal pain. We will offer eligible patients...

Philadelphia, PANA25 participantsAbramson Cancer Center at Penn Medicine

View Study Details

NCT03266640Recruiting

Virus Specific Cytotoxic T-Lymphocytes (CTLs) for Refractory Cytomegalovirus (CMV)

CMV cytotoxic T cells (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Cytokine Capture System will be administered in children, adolescents and young adults (CAYA) with refractory cytomegalovi...

Philadelphia, PAPHASE220 participantsNew York Medical College

View Study Details

NCT05274048Recruiting

Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

This is Phase 1 dose finding trial with potential dose expansion to evaluate the safety, toxicity, recommended phase 2 dose (RP2D), and maximum tolerated dose (MTD) of Neratinib plus TDxD using a stan...

Philadelphia, PAPHASE118 participantsFox Chase Cancer Center

View Study Details

About Geographic Atrophy Clinical Trials in Philadelphia

Geographic atrophy is the advanced form of dry age-related macular degeneration, involving progressive loss of retinal cells. It leads to enlarging blind spots in central vision. Recently approved complement inhibitor therapies can slow progression.

There are currently 25 geographic atrophy clinical trials recruiting participants in Philadelphia, PA. These studies are seeking a combined 5,358 participants. Research is being sponsored by Johns Hopkins University, Children's Hospital of Philadelphia, University of Pennsylvania and 16 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Geographic Atrophy Clinical Trials in Philadelphia — FAQ

Are there geographic atrophy clinical trials in Philadelphia?

Yes, there are 25 geographic atrophy clinical trials currently recruiting in Philadelphia, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Philadelphia?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Philadelphia research site will contact you about next steps.

Are clinical trials in Philadelphia free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Philadelphia studies also compensate for your time and travel.

What geographic atrophy treatments are being tested?

The 25 active trials in Philadelphia are testing new therapies including novel drugs, biologics, and treatment approaches for geographic atrophy.

Data updated July 17, 2026 from ClinicalTrials.gov