16 Breast Cancer Clinical Trials in Pittsburgh, PA (2026)

Q: How do I join a clinical trial in Pittsburgh?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Pittsburgh research site will contact you.

Recruiting Breast Cancer Studies in Pittsburgh

NCT06512350Recruiting

Identifying Patterns in the Breath of Individuals With Breast Cancer

Researchers will compare the breath profiles of women with breast cancer and those without to determine whether there are disease-specific patterns that can be leveraged to facilitate breast cancer de...

Pittsburgh, PA5,175 participantsBreathe BioMedical Inc

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NCT05206331Recruiting

CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a Prospective Study

One of the primary criticisms of mammography is that it leads to unneeded stress and anxiety from identification and biopsy of non-cancerous findings. Contrast-enhanced mammography (CEM) has the poten...

Pittsburgh, PAPHASE42,100 participantsMargarita Louise Zuley

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NCT06105749Recruiting

Biennial CEM in Women With a Personal History of Breast Cancer

This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with mini...

Pittsburgh, PANA1,500 participantsWendie Berg

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NCT02701244Recruiting

A Registry Study of Breast Microseed Treatment

For women diagnosed with early stage breast cancer, lumpectomy followed by radiation is a common treatment option. Radiation treatment is typically delivered to the whole breast, five times per week, ...

Pittsburgh, PA420 participantsConcure Oncology-Breast Microseed Inc.

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NCT01042548Recruiting

Proteomics and Radiomics Research of Breast Cancer Markers in Tissue, Interstitial Fluid and Serum

The current study is a case control study involving comparisons of tissue interstitial fluid from breast cancer and adjacent non-cancerous tissue as well as that from benign breast lesion and its adja...

Pittsburgh, PA300 participantsUniversity of Pittsburgh

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NCT05535192Recruiting

TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

This research is being done to assess whether an exercise intervention with protein intake support vs a health education and support program will make it easier for women age 65 or older who are recei...

Pittsburgh, PANA270 participantsDana-Farber Cancer Institute

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NCT06833853Recruiting

A Study for CTC Expression and cfDNA/RNA Assessment in Metastatic Breast Cancer Patients

The purpose of this research is to learn if the CellSearch Circulating Tumor Cells (CTC) test can help doctors in making decisions about treatment and monitoring of breast cancer. The test consists of...

Pittsburgh, PA187 participantsMenarini Silicon Biosystems, INC

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NCT06022029Recruiting

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

A phase 1, multicenter, open label, non-randomized dose escalation and dose expansion study to examine the maximum tolerated dose, (MTD), minimum effective dose (MED) and/or recommended dose for expan...

Pittsburgh, PAPHASE1168 participantsOncoNano Medicine, Inc.

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NCT03804944Recruiting

Converting HR+ Breast Cancer Into an Individualized Vaccine

Newly diagnosed post-menopausal women with clinical stage II-III, HR+HER2- breast cancer are eligible to a randomized trial, concurrently open at five US academic institutions. Patients receiving 4 mo...

Pittsburgh, PAPHASE2100 participantsWeill Medical College of Cornell University

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NCT07332975Recruiting

ctDNA Positive Patients Diagnosed With cT1bN0 and cT1cN0 TNBC

This translational biomarker study will collect blood in patients Stage I triple negative breast cancer at diagnosis prior to either neoadjuvant treatment or surgery and then during treatment....

Pittsburgh, PA77 participantsUniversity of Pittsburgh

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NCT05501704Recruiting

ETHAN - ET for Male BC

This research study is looking to see how well male breast cancer responds to preoperative treatment with endocrine therapy and which endocrine therapy regimen is the most effective treatment for male...

Pittsburgh, PAPHASE260 participantsJose Pablo Leone

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NCT06923527Recruiting

Circulating Tumor DNA

This is a single-arm, phase II study examining elacestrant in the adjuvant treatment of patients with ER+ breast cancer who test positive for circulating tumor DNA (ctDNA) during the screening period ...

Pittsburgh, PAPHASE250 participantsYale University

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NCT07262138Recruiting

Active Surveillance in Older Women With ER+ Breast Cancer

ACTIVE is a prospective, single-arm, phase I/IIa study examining an active surveillance strategy for small, screen-detected, luminal breast cancer. Patients aged 70 or older with clinical stage I ER+/...

Pittsburgh, PA50 participantsUniversity of Pittsburgh

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NCT05372640Recruiting

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

This phase I trial tests the safety, side effects, and best dose of ZEN003694 when given together with abemaciclib in treating patients with NUT carcinoma, breast cancer or other solid tumors that hav...

Pittsburgh, PAPHASE145 participantsNational Cancer Institute (NCI)

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NCT06115486Recruiting

EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer

The purpose of this research study is to evaluate the outcomes of two standard of care group exercise regimens to increase muscle mass in women who have been treated with breast cancer....

Pittsburgh, PANA30 participantsAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

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NCT05919108Recruiting

Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers

This phase II trial tests how well neratinib prior to the primary treatment (neoadjuvant) works in treating patients with stage I-III HER2 mutated lobular breast cancers. Neratinib is in a class of me...

Pittsburgh, PAPHASE230 participantsVanderbilt-Ingram Cancer Center

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About Breast Cancer Clinical Trials in Pittsburgh

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 16 breast cancer clinical trials recruiting participants in Pittsburgh, PA. These studies are seeking a combined 10,562 participants. Research is being sponsored by Breathe BioMedical Inc, Margarita Louise Zuley, Wendie Berg and 11 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in Pittsburgh — FAQ

Are there breast cancer clinical trials in Pittsburgh?

Yes, there are 16 breast cancer clinical trials currently recruiting in Pittsburgh, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Pittsburgh?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Pittsburgh research site will contact you about next steps.

Are clinical trials in Pittsburgh free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Pittsburgh studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 16 active trials in Pittsburgh are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated July 16, 2026 from ClinicalTrials.gov