31 Pulmonary Hypertension Clinical Trials in Pittsburgh, PA (2026)

Q: Are there pulmonary hypertension clinical trials in Pittsburgh?

Yes, there are 31 pulmonary hypertension clinical trials currently recruiting in Pittsburgh, PA.

Q: How do I join a clinical trial in Pittsburgh?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Pittsburgh research site will contact you.

Q: Are clinical trials in Pittsburgh free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Pulmonary Hypertension Studies in Pittsburgh

NCT00307281Recruiting

Emphysema Research Registry and Biosample Repository

The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and the...

Pittsburgh, PA3,000 participantsUniversity of Pittsburgh

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NCT01241305Recruiting

One-Time DNA Study for Vasculitis

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will pro...

Pittsburgh, PA1,000 participantsUniversity of Pennsylvania

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NCT05813678Recruiting

A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)

This is a 10-year multi-center, global, observational study to further characterize the safety profile of pegvaliase, including hypersensitivity reactions, long-term safety and tolerability, and the e...

Pittsburgh, PA450 participantsBioMarin Pharmaceutical

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NCT06564038Recruiting

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

The purpose of this study is to assess the safety and efficacy of AZD0486 administered as monotherapy or in combination with other anticancer agents in participants with hematological malignancies....

Pittsburgh, PAPHASE1408 participantsAstraZeneca

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NCT06305676Recruiting

Biomarker Approach to Screening for the Early Detection of HPV-related Oropharyngeal Cancer (BASH OPC)

Investigators seek to determine the sensitivity and specificity of a combined HPV 16 DNA and host gene methylation oral biomarker panel to distinguish early Oropharyngeal Cancer (OPC) cases from contr...

Pittsburgh, PA400 participantsH. Lee Moffitt Cancer Center and Research Institute

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NCT06686121Recruiting

Improving Mobility After Revascularization in Peripheral Artery Disease

Lower extremity revascularization combined with supervised exercise significantly improves walking performance compared to revascularization alone in people who have PAD without limb threatening ische...

Pittsburgh, PAPHASE3386 participantsNorthwestern University

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NCT06339177Recruiting

Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study

Background: Hemophagocytic lymphohistiocytosis (HLH) is a disease caused by disrupted immune function. People with HLH are prone to fevers and illnesses, which can be fatal. Some people develop a gen...

Pittsburgh, PA300 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06628128Recruiting

A Long-Term Study of JNT-517 in Participants With Phenylketonuria

The goal of this Phase 3, open-label study is to evaluate the long-term safety of JNT-517 in pediatric and adult participants with Phenylketonuria (PKU) after completion of either Study JNT517-101 (NC...

Pittsburgh, PAPHASE3240 participantsOtsuka Pharmaceutical Development & Commercialization, Inc.

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NCT05319730Recruiting

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

This is a Phase 1/2, multicenter, randomized, open-label umbrella platform study to evaluate the safety and efficacy of investigational agents with or without pembrolizumab and/or chemotherapy, for th...

Pittsburgh, PAPHASE1230 participantsMerck Sharp & Dohme LLC

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NCT06445972Recruiting

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

This is a phase 1/2 multicenter, open-label umbrella platform study that will evaluate the safety and efficacy of sacituzumab tirumotecan (MK-2870) plus paclitaxel versus ramucirumab plus paclitaxel, ...

Pittsburgh, PAPHASE1210 participantsMerck Sharp & Dohme LLC

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NCT06035120Recruiting

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

This is a prospective, open-label, multi-center, single-arm study planned to enroll 200 subjects with heterogeneous emphysema and collateral ventilation (CV) in the target lobe. Subjects will undergo ...

Pittsburgh, PANA200 participantsPulmonx Corporation

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NCT05475925Recruiting

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

This is a multicenter, first-in-human, Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of DR-01 in adult patients with large granular ...

Pittsburgh, PAPHASE1200 participantsDren Bio

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NCT06305234Recruiting

A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

This is a 10-year multi-center, prospective, longitudinal, single arm study evaluating immunologic, inflammatory and laboratory parameters associated with long-term Palynziq treatment in subjects with...

Pittsburgh, PA200 participantsBioMarin Pharmaceutical

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NCT06959277Recruiting

Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems

The goal of this clinical trial is to is to test whether Walkasins can help people with peripheral neuropathy maintain their balance better. The main question it aims to answer is whether participants...

Pittsburgh, PANA200 participantsRxFunction Inc.

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NCT06614322Recruiting

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain t...

Pittsburgh, PAPHASE2190 participantsUniversity of Rochester

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NCT03794076Recruiting

Cromoglicate Adjunctive Therapy for Outpatients With Schizophrenia

This is a double blind adjunctive randomized controlled trial for schizophrenia using cromoglicate....

Pittsburgh, PAPHASE1160 participantsVishwajit Nimgaonkar, MD PhD

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NCT06469944Recruiting

Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

This is a phase 1/2, multicenter, open-label umbrella platform study that will evaluate the safety and tolerability of sacituzumab tirumotecan with pembrolizumab and fluoropyrimidine chemotherapy for ...

Pittsburgh, PAPHASE1160 participantsMerck Sharp & Dohme LLC

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NCT04998669Recruiting

Loncastuximab Tesirine in Combination With Rituximab in Patients With Relapsed or Refractory Follicular Lymphoma

The purpose of this research is to see if Loncastuximab Tesirine in combination with Rituximab will result in higher complete response rate when given to treat follicular lymphoma....

Pittsburgh, PAPHASE2100 participantsJuan P. Alderuccio, MD

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NCT04858256Recruiting

Pacritinib in Relapsed/Refractory T-cell Lymphoproliferative Neoplasms

The main purpose of this study is to determine the effectiveness of the study drug pacritinib in people with relapsed or refractory lymphoproliferative disorders....

Pittsburgh, PAPHASE2100 participantsUniversity of Michigan Rogel Cancer Center

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NCT05004129Recruiting

Safety and Efficacy of Tideglusib in Congenital or Childhood Onset Myotonic Dystrophy

This is an open-label phase 2/3 study for individuals with Congenital Myotonic Dystrophy (Congenital DM1) who participated in the preceding AMO-02-MD-2-003 study or individuals with either Congenital ...

Pittsburgh, PAPHASE276 participantsAMO Pharma Limited

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NCT05452889Recruiting

PET Image in PAH Patients

Pulmonary arterial hypertension (PAH) is mortal disease affecting the blood vessels of the lung. Despite its morbid prognosis, PAH is often misdiagnosed or ignored, with an average time of 44 months b...

Pittsburgh, PAEARLY_PHASE171 participantsStephen Y. Chan

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NCT07405151Recruiting

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

The purpose of this trial is to assess if ifinatamab deruxtecan (I-DXd) can treat esophageal squamous cell carcinoma (ESCC). I-DXd is an antibody-drug conjugate (ADC). An ADC attaches to a protein on ...

Pittsburgh, PAPHASE160 participantsMerck Sharp & Dohme LLC

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NCT06999733Recruiting

A Study Assessing KB801 for the Treatment of Stage 2 or 3 Neurotrophic Keratitis

The Sponsor is developing KB801, a replication-defective, non-integrating herpes simplex virus type 1 (HSV-1)-derived vector engineered to deliver functional full-length human nerve growth factor (NGF...

Pittsburgh, PAPHASE160 participantsKrystal Biotech, Inc.

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NCT04887792Recruiting

Acetazolamide for Treatment Resistant Schizophrenia

This is a double blind adjunctive randomized controlled trial for schizophrenia using acetazolamide....

Pittsburgh, PAPHASE160 participantsVishwajit Nimgaonkar, MD PhD

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NCT06563414Recruiting

A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)

This study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB)....

Pittsburgh, PA40 participantsKrystal Biotech, Inc.

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NCT07156227Recruiting

Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma

This phase I trial tests the safety, side effects, and best dose of camonsertib in combination with stereotactic body radiation therapy in controlling disease in patients with head and neck squamous c...

Pittsburgh, PAPHASE139 participantsNational Cancer Institute (NCI)

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NCT06003387Recruiting

Efficacy and Safety of CSL222 (Etranacogene Dezaparvovec) Gene Therapy in Adults With Hemophilia B With Pretreatment Adeno-associated Virus Serotype 5 (AAV5) Neutralizing Antibodies (Nabs)

The purpose of this study is to assess the risk of bleeding due to failure of expected pharmacological action of CSL222 in adults with severe or moderately severe hemophilia B with detectable pretreat...

Pittsburgh, PAPHASE335 participantsCSL Behring

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NCT05281809Recruiting

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

This trial aims to demonstrate the feasibility of this approach to reliably generate product and to safely administer the product to patients who have B-Cell Lymphoma and B-Acute Lymphoblastic Leukemi...

Pittsburgh, PAPHASE230 participantsJohn Lister

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NCT05653440Recruiting

Balancing Effortful and Errorless Learning in Naming Treatment for Aphasia

Aphasia is a language disorder caused by stroke and other acquired brain injuries that affects over two million people in the United States and which interferes with life participation and quality of ...

Pittsburgh, PAPHASE230 participantsUniversity of Pittsburgh

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NCT07003295Recruiting

Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy

This phase II trial tests the safety and side effects of glofitamab and obinutuzumab and how well they work in treating patients with mantle cell lymphoma that has come back after a period of improvem...

Pittsburgh, PAPHASE220 participantsNational Cancer Institute (NCI)

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NCT05996003Recruiting

NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)

This is a Phase 2, open-label, multi-center, 2-part study of NS-089/NCNP-02 administered by weekly IV infusion to ambulant boys aged ≥4 to \<15 years with DMD due to mutations amenable to exon 44 skip...

Pittsburgh, PAPHASE220 participantsNS Pharma, Inc.

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About Pulmonary Hypertension Clinical Trials in Pittsburgh

Pulmonary hypertension is a type of high blood pressure that affects the arteries in the lungs and the right side of the heart. It can lead to heart failure if untreated. Treatment includes vasodilators, endothelin receptor antagonists, and PDE-5 inhibitors.

There are currently 31 pulmonary hypertension clinical trials recruiting participants in Pittsburgh, PA. These studies are seeking a combined 8,675 participants. Research is being sponsored by University of Pittsburgh, University of Pennsylvania, BioMarin Pharmaceutical and 20 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Pulmonary Hypertension Clinical Trials in Pittsburgh — FAQ

Are there pulmonary hypertension clinical trials in Pittsburgh?

Yes, there are 31 pulmonary hypertension clinical trials currently recruiting in Pittsburgh, PA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Pittsburgh?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Pittsburgh research site will contact you about next steps.

Are clinical trials in Pittsburgh free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Pittsburgh studies also compensate for your time and travel.

What pulmonary hypertension treatments are being tested?

The 31 active trials in Pittsburgh are testing new therapies including novel drugs, biologics, and treatment approaches for pulmonary hypertension.

Data updated July 18, 2026 from ClinicalTrials.gov