62 Rheumatoid Arthritis Clinical Trials in Rochester, MI (2026)

Q: Are there rheumatoid arthritis clinical trials in Rochester?

Yes, there are 62 rheumatoid arthritis clinical trials currently recruiting in Rochester, MI.

Q: How do I join a clinical trial in Rochester?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you.

Q: Are clinical trials in Rochester free?

Yes, clinical trial participation is always free. Study-related treatments, medical tests, and doctor visits are provided at no cost.

Recruiting Rheumatoid Arthritis Studies in Rochester

NCT05366881Recruiting

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers inc...

Rochester, MI7,000 participantsAdela, Inc

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NCT05589714Recruiting

Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants

This is an international, multicenter study with two components: Registry * A standardized genetic screening and a prospective, standardized, cross-sectional clinical data collection * Enrollment is...

Rochester, MI1,500 participantsJaeb Center for Health Research

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NCT06080698Recruiting

Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy f...

Rochester, MI1,030 participantsJohns Hopkins University

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NCT01241305Recruiting

One-Time DNA Study for Vasculitis

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will pro...

Rochester, MI1,000 participantsUniversity of Pennsylvania

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NCT05917522Recruiting

Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

800 adult first time kidney transplant recipients will be enrolled in the Observational Study and followed to evaluate their Human Leukocyte Antigen (HLA)-DR/DQ molecular mismatch (mMM) score as a ris...

Rochester, MI800 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT07472491Recruiting

A Phase 2/3 Study on the Efficacy and Safety of Mangaciclanol for Contrast-Enhanced MRI of CNS or Body in Adult Patients

This is an operationally combined Phase 2/3 study, which will be conducted and evaluated in 2 distinct parts: * Phase 2: Prospective, adaptive, multicenter, non-randomized, single-blind, dose-finding...

Rochester, MI640 participantsGE Healthcare

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NCT05947955Recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

BTI-203 is a randomized, double-blind, placebo-controlled, multicenter, Phase 2 proof-of-concept (POC) study to evaluate the efficacy and safety of rhu-pGSN plus standard of care (SOC) in subjects wit...

Rochester, MI600 participantsBioAegis Therapeutics Inc.

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NCT05844982Recruiting

Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 Mg) Intravitreal Implants Vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following ...

Rochester, MI600 participantsJaeb Center for Health Research

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NCT06702449Recruiting

A Study on the Safety and Immune Response of a Urinary Tract Infection (UTI) Vaccine in Adults 18-64 Years of Age and Clinical Efficacy in Females 18-64 Years of Age

The purpose of this study is to assess safety, reactogenicity, and immune response of the candidate UTI vaccine compared to placebo in adults between and including 18-64 years of age (YOA), and to per...

Rochester, MI448 participantsGlaxoSmithKline

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NCT06075745Recruiting

Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates

This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (...

Rochester, MI416 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06952543Recruiting

Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease

The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the respo...

Rochester, MI400 participantsMayo Clinic

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NCT06033196Recruiting

Tocilizumab in Lung Transplantation

This is a trial in which 350 primary lung transplant recipients will be randomized (1:1) to receive either Tocilizumab (six doses over 20 weeks) plus standard triple maintenance immunosuppression or p...

Rochester, MI350 participantsNational Institute of Allergy and Infectious Diseases (NIAID)

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NCT06568549Recruiting

Reduced Immunosuppression in Older Renal Transplant Recipients With Trugraf®/TRAC Monitoring (RIOT Trial): A Prospective, Randomized, Multicenter Trial.

The purpose of this research is to determine the safety and efficacy of withdrawing MMF (Mycophenolate Mofetil) in kidney transplant recipients who are 55 years or older at the time of receiving a kid...

Rochester, MI350 participantsMayo Clinic

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NCT06200103Recruiting

Schedule De-Escalation of 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

This phase II trial studies how to improve the usage of Lu 177 vipivotide tetraxetan (177Lu-prostate-specific membrane antigen \[PSMA\]-617) for treating patients with castration-resistant prostate ca...

Rochester, MI236 participantsMayo Clinic

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NCT05547698Recruiting

A Study of Venoarterial ECMO vs Off-Pump Bilateral Orthotopic Lung Transplantation

The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which techniq...

Rochester, MI228 participantsMayo Clinic

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NCT06406790Recruiting

CraniSeal Post Approval Study

To collect post-approval data comparing the safety and effectiveness of CraniSeal Dural Sealant to DuraSeal Dural Sealant. The study has been powered specifically to determine whether the CraniSeal de...

Rochester, MI224 participantsPramand LLC

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NCT06822426Recruiting

Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

This is a Phase 3, randomized, double-blind, controlled, adaptive, 2-arm, multicenter study to demonstrate the efficacy and safety of DefenCath in adult participants receiving home Total Parenteral Nu...

Rochester, MI200 participantsCorMedix

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NCT07038200Recruiting

A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous AOC 1020 for the Treatment of Facioscapulohumeral Muscular Dystrophy (FSHD)...

Rochester, MI200 participantsAvidity Biosciences, Inc.

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NCT06008795Recruiting

BLOCK-SAH - PPF-Block for Post-SAH Headache

BLOCK-SAH is a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial with a sequential parallel comparison design (SPCD) of bilateral pterygopalatine fossa (PPF) injecti...

Rochester, MI195 participantsUniversity of Florida

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NCT06614322Recruiting

SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy.

The goal of this clinical trial is to determine whether quantitative sensory testing (QST) can be used to classify participants into pain sub-groups and predict who will respond best to certain pain t...

Rochester, MI190 participantsUniversity of Rochester

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NCT04592445Recruiting

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

The purpose of this clinical study is to evaluate the safety and early effectiveness of a catheter-based procedure that treats a nerve called the right greater splanchnic nerve. The study includes peo...

Rochester, MI150 participantsAxon Therapies, Inc.

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NCT06788886Recruiting

Breathing Practice for Brain and Mental Health in Cancer and Neurodegenerative Diseases

This clinical trial studies the effect of respiratory training for enhancing brain and mental health among patients with multiple sclerosis (MS) and cancer (along with their caregivers). The relations...

Rochester, MI147 participantsMayo Clinic

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NCT07103018Recruiting

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

Study K36-MCRPC-001 is the first in human clinical trial testing KTX-2001 alone and with darolutamide in men with metastatic castration-resistant prostate cancer. The study aims to assess whether the ...

Rochester, MI144 participantsK36 Therapeutics, Inc.

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NCT06879041Recruiting

A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

The main purpose of the study is to assess the safety and tolerability of AZD2284, AZD2287, and AZD2275....

Rochester, MI136 participantsAstraZeneca

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NCT06366464Recruiting

A Study of Pitolisant in Patients With Prader-Willi Syndrome

This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, global clinical study to assess the efficacy and safety of pitolisant in patients living with Prader-Willi syndrome. The ...

Rochester, MI134 participantsHarmony Biosciences Management, Inc.

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NCT07104032Recruiting

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

The purpose of this clinical trial is to evaluate efficacy and safety of tirabrutinib alone compared with rituximab and temozolomide (R-TMZ) combination therapy in participants with Relapsed/Refractor...

Rochester, MI132 participantsOno Pharmaceutical Co., Ltd.

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NCT06375044Recruiting

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

This is an open-label, multicenter phase 1 clinical trial to evaluate the safety and tolerability, efficacy, and pharmacokinetics of SIM0500 in adult participants with Relapsed or Refractory Multiple ...

Rochester, MI130 participantsJiangsu Simcere Pharmaceutical Co., Ltd.

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NCT05987852Recruiting

Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

Chronic intestinal hypoxia and accompanying mucosal inflammation is a hallmark of ulcerative colitis (UC). Hyperbaric oxygen therapy (HBOT) involves breathing 100% oxygen under increased atmospheric p...

Rochester, MI126 participantsNorthwestern University

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NCT06377696Recruiting

Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

This phase III trial evaluates whether patient care can be done remotely for patients having cranial (skull) radiation or who have previously had cranial radiation. In addition, this trial compares st...

Rochester, MI100 participantsMayo Clinic

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NCT07305818Recruiting

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

The purpose of this study is to evaluate how well MER511 is tolerated and what side effects may occur in adults who have Graves' disease. The study drug will be administered either intravenously (into...

Rochester, MI100 participantsMerida Biosciences

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NCT06936566Recruiting

MAGIC Ruxolitinib for aGVHD

This clinical trial will study ruxolitinib-based treatment of acute graft-versus-host-disease (GVHD) that developed following allogeneic hematopoietic cell transplant. Acute GVHD occurs when donor cel...

Rochester, MI98 participantsJohn Levine

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NCT05222620Recruiting

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

This phase II trial compares the effect of single fraction stereotactic radiosurgery to fractionated stereotactic radiosurgery for the treatment of patients with cancer that has spread to the brain (m...

Rochester, MI90 participantsMayo Clinic

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NCT05551793Recruiting

Regeneron AA Multicenter (Dupilumab)

This is a prospective, randomized, double blind, placebo-controlled clinical trial. The study will take place at 4 sites. This trial will enroll a total of 68 patients with moderate to severe AA (affe...

Rochester, MI76 participantsEmma Guttman

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NCT05417867Recruiting

Evaluating the Association Among Changes in Gut Microbiome, Fatigue, and Chemotherapy-Induced Nausea in Early Stage Breast Cancer

This pilot study seeks to understand how changes in the bacteria composition (microbiome) of the gut may be associated with the occurrence of fatigue and chemotherapy-induced nausea (CIN) in women und...

Rochester, MI70 participantsMayo Clinic

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NCT06985147Recruiting

A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

This open-label, multicenter, within-participant dose escalation study examining up to 2 dose levels of DISC-3405 will assess the safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics...

Rochester, MI60 participantsDisc Medicine, Inc

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NCT05191706Recruiting

Evaluate the Safety of DEXYCU for the Treatment of Inflammation Following Ocular Surgery for Childhood Cataract

A Phase 3/4, Prospective, Randomized, Active Treatment-Controlled, Parallel-Design, Multicenter Study to Evaluate the Safety of DEXYCUfor the Treatment of Inflammation Following Ocular Surgery for Chi...

Rochester, MI60 participantsEyePoint Pharmaceuticals, Inc.

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NCT05611775Recruiting

Adult Spinal Deformity Surgery Real-World Functional Activity

The purpose of this study is to measure functional activity and stability in spinal deformity patients utilizing motion analysis testing and accelerometers....

Rochester, MI50 participantsMayo Clinic

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NCT03155854Recruiting

The Effects of Prophylactic Limited Palmar Fasciectomy on Surgical Outcomes and Scarring

Research is instrumental for improving medical care and the patient experience. Finding new surgical techniques can create better outcomes and minimize recovery time and complications for patients. So...

Rochester, MI50 participantsMayo Clinic

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NCT05419492Recruiting

A Clinical Study to Evaluate the Safety and Efficacy of ETX101 in Infants and Children With SCN1A-Positive Dravet Syndrome

ENDEAVOR is a Phase 1/2, 2-part, multicenter study to evaluate the safety and efficacy of ETX101 in participants with SCN1A-positive Dravet syndrome aged ≥6 to \<36 months (Part 1) and aged ≥6 to \<48...

Rochester, MI47 participantsEncoded Therapeutics

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NCT04082520Recruiting

Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy

This phase II trial studies how well lutathera works in treating patients with meningioma that cannot be treated with surgery (inoperable) and is growing, spreading, or getting worse (progressive) aft...

Rochester, MI42 participantsMayo Clinic

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NCT05197530Recruiting

Imaging of Lymphatic Vessels in People With Rheumatoid Arthritis (RA)

Lymphatic transport was previously examined by these investigators using Near InfraRed Indocyanine Green fluorescence imaging (NIR-ICG) of the upper extremities. They established reliable and reproduc...

Rochester, MI40 participantsUniversity of Rochester

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NCT05734404Recruiting

Longitudinal Study for Central Nervous System Vasculitis

Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech imp...

Rochester, MI40 participantsUniversity of Pennsylvania

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NCT05654506Recruiting

Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits

The purpose of this research is to study the safety and efficacy of daratumumab in inducing complete or partial remission in people with proliferative glomerulonephritis with monoclonal immunoglobulin...

Rochester, MI40 participantsMayo Clinic

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NCT06798012Recruiting

A Study of TAK-411 in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

CIDP is an autoimmune disease. This means that the body's germ fighting (immune) system attacks itself. In CIDP, the immune system attacks the protective covering around the nerves called myelin. Over...

Rochester, MI36 participantsTakeda

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NCT05666960Recruiting

R-3750 in Patients With Mild to Moderate Ulcerative Colitis

The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate ulcerative colitis. Patients will take an oral dosage of probio...

Rochester, MI36 participantsRise Therapeutics LLC

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NCT07531745Recruiting

ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome

The primary purpose of this study is to evaluate the safety and tolerability of ION337 in participants with Dravet syndrome (DS)....

Rochester, MI32 participantsIonis Pharmaceuticals, Inc.

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NCT06011109Recruiting

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

The goal of this interventional study is to evaluate the efficacy of APG-157 in combination with Bevacizumab in subjects with recurrent high-grade glioma. The main questions the study aims to answer a...

Rochester, MI30 participantsAveta Biomics, Inc.

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NCT06306963Recruiting

Prevalence of Gastric Motor Dysfunction and Upper GI Symptoms in Gastric Antral Vascular Ectasias

The researchers are trying to find out more about Gastric Antral Vascular Ectasia (GAVE). This is a condition that affects the blood vessels in the stomach, leading to their enlargement and possible b...

Rochester, MI30 participantsMayo Clinic

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NCT07157787Recruiting

Study of ALXN1920 in Adult Participants With Primary Membranous Nephropathy (PMN)

The primary objective of this study is to evaluate the efficacy of ALXN1920 compared with placebo in participants with PMN who are at a high risk for disease progression using 24-hour urine protein cr...

Rochester, MI30 participantsAlexion Pharmaceuticals, Inc.

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NCT06721299Recruiting

Clenbuterol to Target DUX4 in FSHD

The purpose of this study is to determine if Clenbuterol is a therapeutic option for FSHD by determining the safety and tolerability of the medication at three different dose levels....

Rochester, MI30 participantsJeffrey Statland

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NCT05077735Recruiting

Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study

This phase II trial studies the clinical outcomes of hypofractionated radiation therapy in patients with diffuse midline gliomas. This study aims to change the way radiation is delivered, from giving ...

Rochester, MI29 participantsMayo Clinic

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NCT05388006Recruiting

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

This phase II trial tests whether acalabrutinib, venetoclax, and durvalumab work in treating patients with Richter transformation from chronic lymphocytic leukemia or small lymphocytic lymphoma. Richt...

Rochester, MI27 participantsMayo Clinic

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NCT06383585Recruiting

3D DL Ozteo in the Detection of Osseous Changes in Patients With Inflammatory Arthritis

This project intends to explore and validate the utility of new MRI pulse sequence, 3D DL oZTEo, in the detection of osseous erosions of the hand in patients with inflammatory arthritis. The detection...

Rochester, MI25 participantsMayo Clinic

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NCT06444412Recruiting

An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

This clinical trial evaluates whether gallium-68 (Ga-68) prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) imaging is useful in differentiating b...

Rochester, MI25 participantsMayo Clinic

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NCT07093528Recruiting

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

To evaluate the effect of CS reducer implantation in patients with HFPEF and CMD on myocardial ischemia, measured by stress myocardial perfusion using cardiovascular magnetic resonance (CMR)...

Rochester, MI25 participantsMayo Clinic

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NCT07174349Recruiting

Uroselective Alpha-1-Antagonist to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery

The purpose of this research is to see if the use of tamsulosin can decrease both the incidence and duration of urinary retention, as well as hospital length of stay following spine surgery....

Rochester, MI20 participantsMayo Clinic

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NCT06668493Recruiting

Low-grade UTUC Treated With Nadofaragene Firadenovec Administered to Renal Pelvis

The primary purpose of this trial is to evaluate the safety \& tolerability of Nadofaragene Firadenovec in subjects with LG-UTUC. To help with this evaluation, a safety lead-in period will be conducte...

Rochester, MI20 participantsFerring Pharmaceuticals

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NCT06322602Recruiting

Ommaya Reservoir Placement at the Time of Biopsy for Longitudinal Biomarker Collection in Patients With Brain Tumors

This observational trial evaluates the use of Ommaya reservoir placed during a biopsy to collect biomarkers longitudinally in patients with brain tumor. A biomarker is a measurable indicator of the se...

Rochester, MI20 participantsMayo Clinic

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NCT05962346Recruiting

Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

The purpose of this research is to gather information on the safety and effectiveness of a procedure called Fetoscopic Endoluminal Tracheal Occlusion (FETO) at Mayo Clinic. The intent of the FETO proc...

Rochester, MI20 participantsMauro H. Schenone

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NCT05116930Recruiting

Neostigmine and Glycopyrrolate for the Treatment of Headache After Dural Puncture

The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood p...

Rochester, MI18 participantsMayo Clinic

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NCT03281798Recruiting

Fetal Cystoscopy for Severe Lower Urinary Tract Obstruction

The purpose of the study is to study the outcomes of maternal and fetal patients who are undergoing fetal intervention for severe isolated lower urinary tract obstruction (LUTO)....

Rochester, MI10 participantsRodrigo Ruano

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NCT05733312Recruiting

Extracellular Impact of Ultrasound-induced Blood-brain Barrier Disruption

This study seeks to determine the impact of focused ultrasound (FUS) on the composition of the tumor extracellular microenvironment. Researchers will evaluate regions that are very abnormal, as well a...

Rochester, MI6 participantsMayo Clinic

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About Rheumatoid Arthritis Clinical Trials in Rochester

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1.3 million Americans, where the immune system mistakenly attacks joint linings, causing painful swelling, bone erosion, and joint deformity. Early diagnosis and treatment are critical to prevent irreversible damage. Current standard treatments include methotrexate and other DMARDs, TNF inhibitors (etanercept, infliximab), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and JAK inhibitors (tofacitinib, baricitinib). Clinical trials are now exploring next-generation targeted therapies, dual-pathway inhibitors, and treatment strategies aimed at achieving sustained remission rather than just symptom control. Patients with inadequate response to conventional DMARDs or biologics are commonly eligible for enrollment.

There are currently 62 rheumatoid arthritis clinical trials recruiting participants in Rochester, MI. These studies are seeking a combined 19,138 participants. Research is being sponsored by Adela, Inc, Jaeb Center for Health Research, Johns Hopkins University and 33 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Rheumatoid Arthritis Clinical Trials in Rochester — FAQ

Are there rheumatoid arthritis clinical trials in Rochester?

Yes, there are 62 rheumatoid arthritis clinical trials currently recruiting in Rochester, MI. Browse the studies on this page to find one that fits.

How do I join a clinical trial in Rochester?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the Rochester research site will contact you about next steps.

Are clinical trials in Rochester free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many Rochester studies also compensate for your time and travel.

What rheumatoid arthritis treatments are being tested?

The 62 active trials in Rochester are testing new therapies including novel drugs, biologics, and treatment approaches for rheumatoid arthritis.

Data updated July 13, 2026 from ClinicalTrials.gov