19 Breast Cancer Clinical Trials in San Antonio, TX (2026)

Q: How do I join a clinical trial in San Antonio?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Antonio research site will contact you.

Recruiting Breast Cancer Studies in San Antonio

NCT07076485Recruiting

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

To learn about the effects of shorter RNI regimens in patients with breast cance who have had a lumpectomy or mastectomy and who are at higher risk for lower risk for the disease returning....

San Antonio, TXPHASE2768 participantsM.D. Anderson Cancer Center

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NCT07318805Recruiting

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

The purpose of this study is to learn about the safety and effects of the study medicine when given alone or together with other anti-cancer therapies. Anti-cancer therapy is a type of treatment to st...

San Antonio, TXPHASE1260 participantsPfizer

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NCT06993844Recruiting

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

Phase 1/2, open-label study of ETX-636 in participants with advanced solid tumors...

San Antonio, TXPHASE1233 participantsEnsem Therapeutics

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NCT07288359Recruiting

Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Phase I: Characterize safety and tolerability of GVV858 as a single agent and in combination with fulvestrant or letrozole. Identify dose range for optimization/recommended dose for further clinical e...

San Antonio, TXPHASE1205 participantsNovartis Pharmaceuticals

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NCT06784193Recruiting

Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

This is a first-in-human, open-label, multicenter phase 1 study to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of OP-3136, a lysine acetyltran...

San Antonio, TXPHASE1180 participantsOlema Pharmaceuticals, Inc.

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NCT07540572Recruiting

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors

IDE574 is a synthetically manufactured small molecule inhibitor that co-targets the lysine acetyltransferase enzymes KAT6 and KAT7. The purpose of this study is to evaluate the safety, preliminary ef...

San Antonio, TXPHASE1160 participantsIDEAYA Biosciences

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NCT07214662Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-0587 as a Monotherapy and in Combination With Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative (ER+/HER2-) Breast Cancer

This is a first-in-human, Phase Ia/Ib, dose-escalation and expansion study evaluating the safety, pharmacokinetics, and activity of GDC-0587 (cyclin-dependent kinase-4 \[CDK4\] inhibitor) as a monothe...

San Antonio, TXPHASE1136 participantsGenentech, Inc.

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NCT07408089Recruiting

Study of the Kinesin Oral Molecular Degrader BBI-940 in Subjects With Advanced or Metastatic Breast Cancer

This is a first-in-human, open-label, Phase 1 study evaluating BBI-940, an investigational kinesin oral molecular degrader, administered as monotherapy or in combination with fulvestrant in adults wit...

San Antonio, TXPHASE196 participantsBoundless Bio, Inc.

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NCT06999187Recruiting

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

A phase 1a/1b, multicenter, open-label, dose escalation/expansion, multiple-dose study to evaluate the safety and activity of DR-0202 in patients with locally advanced or metastatic, relapsed or refra...

San Antonio, TXPHASE196 participantsDren Bio

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NCT06515470Recruiting

Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of BTX-9341 in Advanced and/or Metastatic Breast Cancer

The purpose of this study is to test BTX-9341 alone or in combination with fulvestrant (a currently marketed medication for breast cancer) in participants with advanced and/or metastatic hormone recep...

San Antonio, TXPHASE182 participantsBiotheryx, Inc.

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NCT07190469Recruiting

PQ203 in Advanced Malignant Tumors Including Triple Negative Breast Cancer

The primary purposes of this study are to determine the safety and tolerability of PQ203 in patients with advanced solid tumors including triple negative breast cancer (TNBC), and to determine a recom...

San Antonio, TXPHASE180 participantsProteinQure Inc.

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NCT05386108Recruiting

Study of Abemaciclib and Elacestrant in Patients With Brain Metastasis Due to ER+/HER-2- Breast Cancer

This is a multi-site, global, open-label study that includes a phase 1b evaluation of elacestrant in combination with abemaciclib in women and men with brain metastases from estrogen receptor (ER)-pos...

San Antonio, TXPHASE173 participantsStemline Therapeutics, Inc.

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NCT07524322Recruiting

Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

This is a phase 1/1b, open-label, multicenter study consisting of sequential parts designed to evaluate the safety, tolerability, and effects pharmacokinetic (PK) profile, and antitumor activity of RG...

San Antonio, TXPHASE163 participantsRegor Pharmaceuticals Inc.

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NCT06827613Recruiting

A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

This is a Phase 1b/2, Open-label Study to Investigate the Safety and Efficacy of Invikafusp alfa (STAR0602), a Selective T Cell Receptor (TCR)-targeting, Bifunctional Antibody-fusion Molecule, in Comb...

San Antonio, TXPHASE150 participantsMarengo Therapeutics, Inc.

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NCT05748834Recruiting

Study of Tucatinib and Doxil in Participants With Human Epidermal Growth Factor Receptor 2 Positive (HER2+) Metastatic Breast Cancer

This clinical trial is evaluating tucatinib in combination with Doxil in participants with human epidermal growth factor 2 positive (HER2+) locally advanced or metastatic breast cancer. The main goals...

San Antonio, TXPHASE236 participantsSCRI Development Innovations, LLC

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NCT07137871Recruiting

Clinical Trial of Avasopasem in Patients With Metastatic Hormone Receptor Positive Breast Cancer With Progression on a CDK 4/6 Inhibitor and Hormonal Therapy

This study aims to evaluate the safety of avasopasem in combination with CDK 4/6 inhibitor and hormonal therapy in women with metastatic hormone receptor positive breast cancer, and to see if the addi...

San Antonio, TXPHASE135 participantsThe University of Texas Health Science Center at San Antonio

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NCT07558733Recruiting

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

The study is a Phase 1b/2, multi-center, open-label, dose escalation trial evaluating the safety and preliminary efficacy of sapanisertib and serabelisib (PIKTOR) with fulvestrant and/or other antican...

San Antonio, TXPHASE132 participantsFaeth Therapeutics

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NCT05029999Recruiting

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

This research study is being done to find out if the immunotherapy drugs called CDX-301 and CDX-1140 in combination with the standard chemotherapy treatment pegylated liposomal doxorubicin (PLD, Doxil...

San Antonio, TXPHASE130 participantsUniversity of Texas Southwestern Medical Center

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NCT07574671Recruiting

Impact of Ketogenic Diet on Tumor Microenvironment in Patients With Breast Cancer

This study is testing the effects of a ketogenic diet on patients with early stage breast cancer. Participants will keep to a ketogenic diet for 3 weeks prior to surgery....

San Antonio, TXNA12 participantsThe University of Texas Health Science Center at San Antonio

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About Breast Cancer Clinical Trials in San Antonio

Breast cancer is a disease in which cells in the breast grow out of control. It is the most common cancer in women worldwide and can also occur in men. Treatment options include surgery, radiation, chemotherapy, hormone therapy, and targeted therapies.

There are currently 19 breast cancer clinical trials recruiting participants in San Antonio, TX. These studies are seeking a combined 2,627 participants. Research is being sponsored by M.D. Anderson Cancer Center, Pfizer, Ensem Therapeutics and 15 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Breast Cancer Clinical Trials in San Antonio — FAQ

Are there breast cancer clinical trials in San Antonio?

Yes, there are 19 breast cancer clinical trials currently recruiting in San Antonio, TX. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Antonio?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Antonio research site will contact you about next steps.

Are clinical trials in San Antonio free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Antonio studies also compensate for your time and travel.

What breast cancer treatments are being tested?

The 19 active trials in San Antonio are testing new therapies including novel drugs, biologics, and treatment approaches for breast cancer.

Data updated July 21, 2026 from ClinicalTrials.gov