11 Lung Cancer Clinical Trials in San Diego, CA (2026)

Q: How do I join a clinical trial in San Diego?

Browse available studies, click one that interests you, and complete the free eligibility form. A study coordinator at the San Diego research site will contact you.

Recruiting Lung Cancer Studies in San Diego

NCT06627647Recruiting

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC

The purpose of ARTEMIDE-Lung03 is to evaluate the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line treatmen...

San Diego, CAPHASE31,160 participantsAstraZeneca

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NCT06577883Recruiting

Next Generation Chest X-Ray Tomosynthesis for Screening of Lung Cancer

The goal of this observational clinical trial is to learn if chest tomosynthesis is a potential alternative to computed tomography for the detection of lung cancer. It will also develop artificial int...

San Diego, CA1,000 participantsUniversity of California, San Diego

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NCT06422143Recruiting

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; M...

San Diego, CAPHASE3851 participantsMerck Sharp & Dohme LLC

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NCT06417814Recruiting

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

This study will assess the effect of Dato-DXd in combination with osimertinib or Dato-DXd monotherapy versus platinum-based doublet chemotherapy in terms of progression-free survival (PFS)....

San Diego, CAPHASE3744 participantsAstraZeneca

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NCT06890598Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRA...

San Diego, CAPHASE3700 participantsEli Lilly and Company

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NCT06917079Recruiting

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

A first in human study to evaluate the safety and preliminary antitumor activity of BBO-11818, a pan-KRAS inhibitor, in subjects with locally advanced unresectable or metastatic KRAS mutant solid tumo...

San Diego, CAPHASE1665 participantsTheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

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NCT06162221Recruiting

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors as a monotherapy or combined with Stan...

San Diego, CAPHASE1616 participantsRevolution Medicines, Inc.

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NCT06350097Recruiting

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

The purpose of this study is to evaluate efficacy and safety of osimertinib (tablet) in combination with Dato-DXd (i.v. infusion) compared with osimertinib (tablet) monotherapyas a first-line therapy ...

San Diego, CAPHASE3582 participantsAstraZeneca

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NCT06452277Recruiting

A Study to Learn More About How Well Sevabertinib (BAY 2927088) Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Researchers are looking for a better way to treat people who have advanced non-small cell lung cancer (NSCLC) with specific genetic changes called human epidermal growth factor receptor 2 (HER2) mutat...

San Diego, CAPHASE3444 participantsBayer

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NCT07291037Recruiting

Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

TROPION-Lung17 will measure the efficacy and safety of datopotamab deruxtecan (Dato-DXd) compared with docetaxel in patients with trophoblast cell surface protein 2 (TROP2) positive advanced or metast...

San Diego, CAPHASE3400 participantsAstraZeneca

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NCT05467748Recruiting

EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

This is an open label, single arm, phase Ib/II clinical trial of checkpoint blockade, pembrolizumab and EZH2 inhibitor, tulmimetostat combination therapy for patients with advanced non-small cell lung...

San Diego, CAPHASE166 participantsVA Office of Research and Development

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About Lung Cancer Clinical Trials in San Diego

Lung cancer is the leading cause of cancer death worldwide, starting in the cells of the lungs. The two main types are non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Treatments include surgery, chemotherapy, radiation, immunotherapy, and targeted drugs.

There are currently 11 lung cancer clinical trials recruiting participants in San Diego, CA. These studies are seeking a combined 7,228 participants. Research is being sponsored by AstraZeneca, University of California, San Diego, Merck Sharp & Dohme LLC and 5 other organizations. Clinical trial participation is free and participants receive study-related medical care at no cost.

Lung Cancer Clinical Trials in San Diego — FAQ

Are there lung cancer clinical trials in San Diego?

Yes, there are 11 lung cancer clinical trials currently recruiting in San Diego, CA. Browse the studies on this page to find one that fits.

How do I join a clinical trial in San Diego?

Browse the studies listed above, click one that interests you, and complete the free eligibility form. A study coordinator at the San Diego research site will contact you about next steps.

Are clinical trials in San Diego free?

Yes, clinical trial participation is always free. Study-related treatment, medical tests, and doctor visits are provided at no cost. Many San Diego studies also compensate for your time and travel.

What lung cancer treatments are being tested?

The 11 active trials in San Diego are testing new therapies including novel drugs, biologics, and treatment approaches for lung cancer.

Data updated July 16, 2026 from ClinicalTrials.gov