Is NCT03747458 recruiting?

Yes, NCT03747458 is currently recruiting. This nasal polyps study is enrolling participants at 31 locations.

What is the status of NCT03747458?

NCT03747458 is currently recruiting. This is a Clinical Trial trial for nasal polyps sponsored by Optinose US Inc.. Status verified Dec 11, 2025 via ClinicalTrials.gov.

Where is NCT03747458 enrolling participants?

NCT03747458 has 31 active sites including Birmingham, Alabama; Gilbert, Arizona; Bakersfield, California and 28 more locations.

Who is eligible for NCT03747458?

This nasal polyps trial is targeting 72 participants. Detailed eligibility criteria including age requirements and medical history are listed on this page.

Who can participate in this Nasal Polyps study?

Eligibility varies by study, but generally includes adults diagnosed with Nasal Polyps who meet specific medical criteria. Complete the interest form above to learn if you may qualify.

Is the study available in Birmingham, Alabama?

Yes! This study has active research sites in Birmingham, Gilbert, Bakersfield. When you express interest, you'll be connected with the site nearest to you.

What are the benefits of joining a clinical trial for Nasal Polyps?

Participants often receive: access to new treatments before they're widely available, close monitoring by medical professionals, study-related care at no cost, and the opportunity to contribute to medical research.

⚡Your ready-to-use recruitment solution: IRB-compliant, SEO-optimized website that automatically routes qualified patient leads to your clinical study (14-day free trial, then $44/mo)

NCT03747458 RECRUITINGIRB Ready

OPN-375 Efficacy and Safety in Adolescents With Bilateral Nasal Polyps

Express Your Interest Today

Interested in learning more? Complete the form below.

First Name *

Last Name *

Email Address *

Phone Number *

ZIP Code *

Age Range *

Preferred Location

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

No-Cost Study Care
Advance Medical Science
Contribute to groundbreaking research
Cutting-Edge Treatment
Access to innovative therapies
Expert Medical Care
Close monitoring by specialists
Possible Compensation*
For time and travel (varies by study)
Help Others
Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

1Submit this form
2Phone screening
3In-person assessment if eligible
4Begin participation

About This Study

This is a 16-Week Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multicenter Study Evaluating the Efficacy and Safety of OPN-375 186 μg Twice a Day (BID) in Adolescents with Bilateral Nasal Polyps followed by a 12-Week Open-Label Treatment Phase. The total planned number of subjects is approximately 72 adolescents (12-17 years of age) who will be randomly assigned to receive 1 of 2 study treatments using a 2:1 ratio (OPN-375 186 μg: Placebo).

Who Can Participate

Inclusion Criteria

Male or female subjects aged 12 to 17 years, inclusive, at time of Visit 1 (Screening). 2. Female subjects, if sexually active, must, 1. be practicing an effective method of birth control (e.g., prescription oral contraceptives, contraceptive injections, contraceptive patch, intrauterine device, double-barrier method \[e.g., condoms, diaphragm, or cervical cap with spermicidal foam, cream, or gel\], or male partner sterilization) before entry and throughout the study, or 2. be surgically sterile (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy), or 3. be abstinent. 3. All female subjects not documented to be infertile (e.g., infertility due to congenital abnormality or surgical sterilization) must have a negative serum or urine beta-human chorionic gonadotropin (hCG) at Visit 1 (Screening) and a negative urine pregnancy test at the Visit 2 (Day 1/Randomization/Baseline). 4. Must have bilateral n

❓ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

📋

Study Type

INTERVENTIONAL

👥

Target Enrollment

72 participants

🎂

Age Range

12 Years - 17 Years

⚧

Gender

ALL

🏢

Sponsor

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

🔒 Secure · 🏥 Expert Care

Find More Ankylosing Spondylitis Trials by City

Browse all ankylosing spondylitis clinical trials in these cities — not just this study.

Birmingham, Alabama Gilbert, Arizona Bakersfield, California Fresno, California Los Angeles, California Orange, California

Browse More Trials by Condition

Ankylosing Spondylitis Trials All Conditions →

Looking for Nasal Polyps Treatment in Birmingham?

Join others in Alabama exploring innovative treatment options through clinical research

Nasal Polyps Treatment Options in Birmingham, Alabama

If you're searching for Nasal Polyps treatment in Birmingham, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Birmingham, Gilbert, Bakersfield and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Nasal Polyps. All study-related care is provided at no cost to participants.

Local Sites

3 locations in Alabama

Now Enrolling

Up to 72 participants

Quick Start

Screening available now

Why Consider a Clinical Trial for Nasal Polyps?

Potential Benefits

✓Access to new treatment approaches before public availability
✓Close monitoring by experienced medical professionals
✓Study-related care provided at no cost
✓Contribute to medical research for Nasal Polyps

What to Expect

→Initial screening to determine eligibility
→Regular check-ups and monitoring visits
→Possible compensation for time and travel
→You can withdraw at any time

Frequently Asked Questions About This Nasal Polyps Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT03747458. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.