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NCT04661358RECRUITINGIRB Ready

Fenofibrate for Prevention of DR Worsening

(Protocol AF)

Sponsored by Jaeb Center for Health Research

Quick Self-Assessment

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Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME at baseline.

Who Can Participate

Inclusion Criteria

Age โ‰ฅ18 years and \< 80 years.
Type 1 or type 2 diabetes.
At least one eye with the following:
Mild to moderately severe NPDR (defined by ETDRS DR severity level 35 to 47), confirmed by central Reading Center grading of fundus photographs.
Best-corrected E-ETDRS visual acuity letter score of โ‰ฅ74 (approximate Snellen equivalent 20/32 or better). If best corrected letter score is 74-78, investigator must verify that vision loss is not due to the presence of CI-DME, cataract, or other condition that may affect visual acuity during the course of the study.
If only one eye is eligible, the non-study eye must have at least microaneurysms only (DR severity level 20) Key

Exclusion Criteria

Eye-level exclusion criteria (the eye is ineligible if any of the following is met):
Current CI-DME based on clinical exam or OCT central subfield thickness (CST)
Zeiss Cirrus: CST โ‰ฅ290 ยตm in women or โ‰ฅ 305 ยตm in men
Heidelberg Spectralis: CST โ‰ฅ305 ยตm in

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

560 participants

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Age Range

18 Years - 80 Years

โšง

Gender

ALL

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Sponsor

Jaeb Center for Health Research

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

Glendale

California

Location available
View Glendale location page
RECRUITING

Huntington Beach

California

Location available
View Huntington Beach location page
RECRUITING

Loma Linda

California

Location available
View Loma Linda location page
RECRUITING

Pasadena

California

Location available
View Pasadena location page
RECRUITING

Sacramento

California

Location available
View Sacramento location page
RECRUITING

San Francisco

California

Location available
View San Francisco location page
RECRUITING

Fort Myers

Florida

Location available
View Fort Myers location page
RECRUITING

Jacksonville

Florida

Location available
View Jacksonville location page
RECRUITING

Jacksonville

Florida

Location available
View Jacksonville location page

๐Ÿ“ And 57 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Looking for Diabetic Retinopathy Treatment in Glendale?

Join others in California exploring innovative treatment options through clinical research

Diabetic Retinopathy Treatment Options in Glendale, California

If you're searching for Diabetic Retinopathy treatment in Glendale, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Glendale, Huntington Beach, Loma Linda and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Diabetic Retinopathy. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 560 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Diabetic Retinopathy?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Diabetic Retinopathy

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Diabetic Retinopathy Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT04661358. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.