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NCT05004987RECRUITINGIRB Ready

Aβ Dynamics in LLMD

Sponsored by NYU Langone Health

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...
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1 of 60 participants interested
2% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depression and the biological factors associated with AD is unknown, the only way to understand cause and associated risk is to treat the depressive symptoms and examine the effects on AD biomarkers. The study involves an FDA-approved treatment for major depressive disorder.

Who Can Participate

Inclusion Criteria

Male and female subjects, age 60+ years inclusive, at the time of signing the informed consent. 2. Meeting Structured Clinical Interview (SCID-5-RV) for DSM-5 criteria for Major depressive disorder. 3. Montgomery-Åsberg Depression Rating Scale (MADRS) ≥18. 4. Have results of a physical examination, neurological examination, vitals, and EKG within normal limits at screening. 5. Cognitively unimpaired at screening visit as defined by Mini-Mental State Examination (MMSE) \>27. 6. Clinical Dementia Rating Scale (CDR) Global of 0\*. 7. A score of 85 or greater on the RBANS delayed memory index score. 8. Fluent in English, because some of the instruments used in this study have not been translated and validated in other languages, and are able to read at a 6th grade level or equivalent, as determined by the PI. 9. Medically stable with no significant cerebrovascular, neurological, or systemic disease expected to interfere with the study. 10. Adequate auditory acuity a

❓ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

60 participants

Gender

ALL

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Sponsor

NYU Langone Health

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

New York

New York

Location available
RECRUITING

Orangeburg

New York

Location available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

🔒 Secure · 🏥 Expert Care

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Join others in New York exploring innovative treatment options through clinical research

I cannot determine the primary medical condition from the provided information. The study title "Aβ Dynamics in LLMD" uses abbreviations that are unclear, the conditions section only lists drugs (Escitalopram Oxalate and Placebo), and the brief summary appears to be incomplete (showing only a localhost URL). Without more specific information about what medical condition this trial is investigating, I cannot provide the patient-facing condition that people would search for. Treatment Options in New York, New York

If you're searching for I cannot determine the primary medical condition from the provided information. The study title "Aβ Dynamics in LLMD" uses abbreviations that are unclear, the conditions section only lists drugs (Escitalopram Oxalate and Placebo), and the brief summary appears to be incomplete (showing only a localhost URL). Without more specific information about what medical condition this trial is investigating, I cannot provide the patient-facing condition that people would search for. treatment in New York, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in New York, Orangeburg and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with I cannot determine the primary medical condition from the provided information. The study title "Aβ Dynamics in LLMD" uses abbreviations that are unclear, the conditions section only lists drugs (Escitalopram Oxalate and Placebo), and the brief summary appears to be incomplete (showing only a localhost URL). Without more specific information about what medical condition this trial is investigating, I cannot provide the patient-facing condition that people would search for.. All study-related care is provided at no cost to participants.

Local Sites
2 locations in New York
Now Enrolling
Up to 60 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for I cannot determine the primary medical condition from the provided information. The study title "Aβ Dynamics in LLMD" uses abbreviations that are unclear, the conditions section only lists drugs (Escitalopram Oxalate and Placebo), and the brief summary appears to be incomplete (showing only a localhost URL). Without more specific information about what medical condition this trial is investigating, I cannot provide the patient-facing condition that people would search for.?

Potential Benefits

  • Access to new treatment approaches before public availability
  • Close monitoring by experienced medical professionals
  • Study-related care provided at no cost
  • Contribute to medical research for I cannot determine the primary medical condition from the provided information. The study title "Aβ Dynamics in LLMD" uses abbreviations that are unclear, the conditions section only lists drugs (Escitalopram Oxalate and Placebo), and the brief summary appears to be incomplete (showing only a localhost URL). Without more specific information about what medical condition this trial is investigating, I cannot provide the patient-facing condition that people would search for.

What to Expect

  • Initial screening to determine eligibility
  • Regular check-ups and monitoring visits
  • Possible compensation for time and travel
  • You can withdraw at any time

Frequently Asked Questions About This I cannot determine the primary medical condition from the provided information. The study title "Aβ Dynamics in LLMD" uses abbreviations that are unclear, the conditions section only lists drugs (Escitalopram Oxalate and Placebo), and the brief summary appears to be incomplete (showing only a localhost URL). Without more specific information about what medical condition this trial is investigating, I cannot provide the patient-facing condition that people would search for. Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT05004987. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.