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NCT06502964RECRUITINGIRB Ready

Study of ALTO-101 in Patients With Schizophrenia

Sponsored by Alto Neuroscience

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...
๐Ÿ“Š
1 of 82 participants interested
1% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This is a Phase 2, double-blind, placebo-controlled, two-way crossover study to compare the efficacy of ALTO-101T versus placebo in change in electroencephalogram (EEG) cognitive processing markers and measures of cognition. Additional goals are to assess pharmacokinetic (PK), safety, and tolerability of the recently developed ALTO-101T transdermal delivery system (TDS) formulation in a patient population.

Who Can Participate

Inclusion Criteria

Schizophrenia diagnosis for at least one year
Cognitive impairment
Stable doses of 1-2 antipsychotic medication(s) for at least 8 weeks at Visit 2
Positive and Negative Syndrome Scale (PANSS) score: items P1, P3-P6 โ‰ค 5 and item P2 and P7 โ‰ค 4 during screening
Have a body mass index (BMI) โ‰ฅ 18.0 and โ‰ค 37.0 kg/m2 (inclusive)
Willing to comply with all study assessments and procedures

Exclusion Criteria

Evidence of unstable medical condition
Acute psychiatric decompensation or severity of symptoms requiring psychiatric hospitalization in past 6 months
Diagnosis of schizoaffective or bipolar affective disorder, dementia, or intellectual disability
Current episode of major depressive disorder (MDD)
Use of mood stabilizer, clozapine, and/or daily benzodiazepine
Current moderate or severe substance use disorder

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

82 participants

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Age Range

21 Years - 55 Years

โšง

Gender

ALL

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Sponsor

Alto Neuroscience

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

Garden Grove

California

Location available
View Garden Grove location page
RECRUITING

Los Angeles

California

Location available
View Los Angeles location page
RECRUITING

Orange

California

Location available
View Orange location page
RECRUITING

Walnut Creek

California

Location available
View Walnut Creek location page
RECRUITING

Hollywood

Florida

Location available
View Hollywood location page
RECRUITING

Tampa

Florida

Location available
View Tampa location page
RECRUITING

Snellville

Georgia

Location available
View Snellville location page
RECRUITING

Chicago

Illinois

Location available
View Chicago location page
RECRUITING

Gaithersburg

Maryland

Location available
View Gaithersburg location page

๐Ÿ“ And 5 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

๐Ÿ”’ Secure ยท ๐Ÿฅ Expert Care

Looking for Schizophrenia Treatment in Garden Grove?

Join others in California exploring innovative treatment options through clinical research

Schizophrenia Treatment Options in Garden Grove, California

If you're searching for Schizophrenia treatment in Garden Grove, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Garden Grove, Los Angeles, Orange and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Schizophrenia. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 82 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Schizophrenia?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Schizophrenia

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Schizophrenia Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06502964. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.