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Study to Assess the Efficacy, Safety, and Tolerability of NOC-110 in Adults With Refractory or Unexplained Chronic Cough

(ASPIRE)

Sponsored by Nocion Therapeutics

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Current Status

Recruiting

Auto-verified from ClinicalTrials.gov

Verified Feb 17, 2026

Phase

Clinical Trial

Sponsor

Nocion Therapeutics

Enrollment Target

455

Start Date

Sep 2024

๐Ÿ“Š
1 of 455 participants interested
0% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

This is a phase 2b, randomized, double-blind, placebo-controlled study investigating the efficacy, safety, and tolerability of Taplucainium Inhalation Powder (NOC-110) once daily in adults with refractory or unexplained chronic cough.

Who Can Participate

Inclusion Criteria

Refractory or unexplained chronic cough for โ‰ฅ 12 months.
Women of childbearing potential agree to follow the protocol specified contraceptive - guidance during the study.
Males who are not vasectomized must agree to use the contraceptive methods defined in the protocol.
Able to provide Informed Consent.

Exclusion Criteria

Previous exposure to taplucainium (formerly NTX-1175) or known allergy or hypersensitivity to taplucainium, its excipients/metabolites, or related compounds.
Participants who are currently participating in another drug or device clinical study
Participants who have participated in an Acute or Chronic Cough investigational study within 60 days before the start of the Screening.
Current diagnosis of chronic obstructive pulmonary disease, bronchiectasis, unexplained pulmonary fibrosis, hemoptysis, bronchial asthma, or other pulmonary disease.
Respiratory tract infection within 4 weeks of Screening or during screening period.

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

455 participants

๐ŸŽ‚

Age Range

18 Years - 80 Years

โšง

Gender

ALL

๐Ÿข

Sponsor

Nocion Therapeutics

Study Locations

Choose your preferred location or select flexible during enrollment

RECRUITING

Foley

Alabama

Location available
View Foley location page
RECRUITING

Scottsdale

Arizona

Location available
View Scottsdale location page
RECRUITING

Tempe

Arizona

Location available
View Tempe location page
RECRUITING

Little Rock

Arkansas

Location available
View Little Rock location page
RECRUITING

Huntington Beach

California

Location available
View Huntington Beach location page
RECRUITING

Laguna Niguel

California

Location available
View Laguna Niguel location page
RECRUITING

Modesto

California

Location available
View Modesto location page
RECRUITING

Newport Beach

California

Location available
View Newport Beach location page
RECRUITING

Paramount

California

Location available
View Paramount location page

๐Ÿ“ And 60 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

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Looking for Chronic Cough Treatment in Foley?

Join others in Alabama exploring innovative treatment options through clinical research

Chronic Cough Treatment Options in Foley, Alabama

If you're searching for Chronic Cough treatment in Foley, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Foley, Scottsdale, Tempe and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Chronic Cough. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Alabama
Now Enrolling
Up to 455 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Chronic Cough?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Chronic Cough

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Chronic Cough Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06504446. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.