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Metformin and Vascular Function in Prediabetes

Sponsored by Diana Jalal

Quick Self-Assessment

See if you qualify and express your interest

Preparing your pre-screening questions...

Current Status

Withdrawn

Auto-verified from ClinicalTrials.gov

Verified Dec 24, 2025

Phase

Clinical Trial

Sponsor

Diana Jalal

Enrollment Target

30

Start Date

Nov 2024

๐Ÿ“Š
1 of 30 participants interested
3% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

The goal of this clinical trial is to investigate whether metformin improves vascular function in individuals with prediabetes. The main questions it aims to answer are: 1. Does metformin improve large conduit artery endothelial function in individuals with prediabetes? 2. Does metformin improve microvascular endothelial function in individuals with prediabetes? Researchers will compare metformin to a placebo to see if metformin improves vascular function in prediabetes.

Who Can Participate

Inclusion Criteria

Age 18-55 years
Prediabetes defined as an HbA1c between 5.7% and 6.4%
Able to provide informed consent

Exclusion Criteria

Current use of metformin or metformin use within the past 12 months
Current use of medicated contraindicated for use with metformin
Current use of vitamin C supplement
Current smoker or quit smoking within the last 6 months
Pregnant, breastfeeding, planning to become pregnant, or unwilling to use adequate birth control
Uncontrolled hypertension (Systolic blood pressure \>140 mmHg)
Body Mass Index \> 40 kg/m2
History of diabetes, myocardial infarction, heart failure, liver disease, or chronic kidney disease (estimated glomerular filtration rate \< 45 ml/min/1.73m2)
History of lactic acidosis
History of alcohol abuse
Severe infection within the last 30 days
Immunosuppressive therapy within the past year
Life expectancy \< 1 year
Allergy to metformin, nitroglycerin, sodium nitroprusside, ringer's lactate

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

30 participants

๐ŸŽ‚

Age Range

18 Years - 55 Years

โšง

Gender

ALL

๐Ÿข

Sponsor

Diana Jalal

Study Locations

Choose your preferred location or select flexible during enrollment

Unknown

Iowa City

Iowa

Location available
View Iowa City location page
Unknown

Iowa City

Iowa

Location available
View Iowa City location page

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

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Find More Essential Tremor Trials by City

Browse all essential tremor clinical trials in these cities โ€” not just this study.

Looking for Prediabetes Treatment in Iowa City?

Join others in Iowa exploring innovative treatment options through clinical research

Prediabetes Treatment Options in Iowa City, Iowa

If you're searching for Prediabetes treatment in Iowa City, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Iowa City, Iowa City and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Prediabetes. All study-related care is provided at no cost to participants.

Local Sites
2 locations in Iowa
Now Enrolling
Up to 30 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Prediabetes?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Prediabetes

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Prediabetes Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06526494. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.