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A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease

(ReΟ„ain)

Sponsored by Janssen Pharmaceutica N.V., Belgium

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Current Status

Active, Not Recruiting

Auto-verified from ClinicalTrials.gov

Verified Feb 17, 2026

Phase

Clinical Trial

Sponsor

Janssen Pharmaceutica N.V., Belgium

Enrollment Target

498

Start Date

Jul 2024

πŸ“Š
1 of 498 participants interested
0% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

The purpose of this study is to assess the effect of JNJ-64042056 on cognitive decline, as measured by Preclinical Alzheimer's disease Cognitive Composite 5 (PACC-5) compared with placebo.

Who Can Participate

Inclusion Criteria

Elevated brain tau pathology defined as Braak 3 region of interest standardized uptake value ratio (ROI SUVR) greater than (\>) 1.1 (or equivalent based on emerging data) on a screening tau PET scan, reviewed centrally by a qualified reader to enrich for probability of disease progression during the study
Clinical Dementia Rating (CDR) global score of 0 at screening and baseline
Mini Mental State Examination (MMSE) greater than or equal to (\>=) 27 (with educational adjustment) at screening
Able to read and write and with a minimum 5 years of formal education as reported by participant and study partner at screening
A participant must be of non-childbearing potential

Exclusion Criteria

History consistent with or known autosomal dominant AD (mutation identified in the family and/or participant)
Fulfills diagnostic criteria for Alzheimer's Dementia or non-Alzheimer's Dementia, including, but not limited to Frontotemporal Dementia (FTD), Diffuse Lewy

❓ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

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Study Type

INTERVENTIONAL

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Target Enrollment

498 participants

πŸŽ‚

Age Range

55 Years - 75 Years

⚧

Gender

ALL

🏒

Sponsor

Janssen Pharmaceutica N.V., Belgium

Study Locations

Choose your preferred location or select flexible during enrollment

Unknown

Phoenix

Arizona

Location available
View Phoenix location page
Unknown

Irvine

California

Location available
View Irvine location page
Unknown

Murrieta

California

Location available
View Murrieta location page
Unknown

Riverside

California

Location available
View Riverside location page
Unknown

San Diego

California

Location available
View San Diego location page
Unknown

New Haven

Connecticut

Location available
View New Haven location page
Unknown

Atlantis

Florida

Location available
View Atlantis location page
Unknown

Boca Raton

Florida

Location available
View Boca Raton location page
Unknown

Clermont

Florida

Location available
View Clermont location page

πŸ“ And 25 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

Express your interest in this groundbreaking clinical trial

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Find More Alzheimers Disease Trials by City

Browse all alzheimers disease clinical trials in these cities β€” not just this study.

Looking for Alzheimer's Disease Treatment in Phoenix?

Join others in Arizona exploring innovative treatment options through clinical research

Alzheimer's Disease Treatment Options in Phoenix, Arizona

If you're searching for Alzheimer's Disease treatment in Phoenix, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Phoenix, Irvine, Riverside and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Alzheimer's Disease. All study-related care is provided at no cost to participants.

Local Sites
3 locations in Arizona
Now Enrolling
Up to 498 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Alzheimer's Disease?

Potential Benefits

  • βœ“Access to new treatment approaches before public availability
  • βœ“Close monitoring by experienced medical professionals
  • βœ“Study-related care provided at no cost
  • βœ“Contribute to medical research for Alzheimer's Disease

What to Expect

  • β†’Initial screening to determine eligibility
  • β†’Regular check-ups and monitoring visits
  • β†’Possible compensation for time and travel
  • β†’You can withdraw at any time

Frequently Asked Questions About This Alzheimer's Disease Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06544616. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.