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A Study to Assess Safety and Tolerability of PCRX-201 in Subjects With Painful Osteoarthritis of the Knee

Sponsored by Pacira Pharmaceuticals, Inc

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Current Status

Recruiting

Auto-verified from ClinicalTrials.gov

Verified Jun 26, 2025

Phase

Clinical Trial

Sponsor

Pacira Pharmaceuticals, Inc

Enrollment Target

135

Start Date

Feb 2025

๐Ÿ“Š
1 of 135 participants interested
1% interest

Express Your Interest Today

Interested in learning more? Complete the form below.

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Advance Medical Science

    Contribute to groundbreaking research

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel (varies by study)

  • Help Others

    Benefit future patients

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3In-person assessment if eligible
  4. 4Begin participation

About This Study

The goal of this clinical trial is to learn if a single knee injection of different doses (Dose A and Dose B) of an investigation product PCRX-201, following steroid pretreatment, is safe and tolerable in male of female patients 45 to 80 years old with osteoarthritis of the knee. It will also learn how the body reacts to the PCRX-201 injection and how effective the treatment is.

Who Can Participate

Inclusion Criteria

Subjects must be willing and able to comply with the study procedures and visit schedule and able to follow verbal and written instructions.
Subjects must be male or female and 45 to 80 years old, inclusive, at Screening.
Subjects must exhibit symptoms associated with osteoarthritis of the index knee for โ‰ฅ12 months before Screening (subject self-reporting is acceptable).
Subjects must have index knee pain for \>15 days over the last month before Screening (subject self-reporting is acceptable).
Subjects must have failed 2 or more therapies: Restricted physical activity as per Osteoarthritis Research Society International (OARSI) core level recommendation, ie, "structured land-based exercise" (this may include physical therapy), and failure of an additional type of conservative therapy for OA of the index knee, eg, nonselective NSAIDs or COX-2 inhibitors, in the past 12 months.
Subjects must have a body mass index (BMI) โ‰ค40 kg/m2 at Screening.

โ“ Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility during the screening process.

Study Details

๐Ÿ“‹

Study Type

INTERVENTIONAL

๐Ÿ‘ฅ

Target Enrollment

135 participants

๐ŸŽ‚

Age Range

45 Years - 80 Years

โšง

Gender

ALL

๐Ÿข

Sponsor

Pacira Pharmaceuticals, Inc

Study Locations

Choose your preferred location or select flexible during enrollment

NOT_YET_RECRUITING

Beverly Hills

California

Location available
View Beverly Hills location page
RECRUITING

Huntington Beach

California

Location available
View Huntington Beach location page
RECRUITING

La Mesa

California

Location available
View La Mesa location page
RECRUITING

West Hills

California

Location available
View West Hills location page
RECRUITING

Daytona Beach

Florida

Location available
View Daytona Beach location page
RECRUITING

Oldsmar

Florida

Location available
View Oldsmar location page
RECRUITING

West Palm Beach

Florida

Location available
View West Palm Beach location page
RECRUITING

Winter Park

Florida

Location available
View Winter Park location page
NOT_YET_RECRUITING

Boise

Idaho

Location available
View Boise location page

๐Ÿ“ And 8 more locations available

Frequently Asked Questions

Q:What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Q:Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Q:Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Q:Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

Q:How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.

Still have questions? Our study coordinators are here to help.

Ready to Make a Difference?

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Browse all osteoarthritis clinical trials in these cities โ€” not just this study.

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Looking for Knee Osteoarthritis Treatment in Beverly Hills?

Join others in California exploring innovative treatment options through clinical research

Knee Osteoarthritis Treatment Options in Beverly Hills, California

If you're searching for Knee Osteoarthritis treatment in Beverly Hills, participating in a clinical research study may provide access to innovative approaches under expert medical supervision. This study is actively recruiting participants in Beverly Hills, Huntington Beach, La Mesa and surrounding areas.

Clinical trials offer participants the opportunity to receive cutting-edge treatments while contributing to medical research that may help future patients with Knee Osteoarthritis. All study-related care is provided at no cost to participants.

Local Sites
3 locations in California
Now Enrolling
Up to 135 participants
Quick Start
Screening available now

Why Consider a Clinical Trial for Knee Osteoarthritis?

Potential Benefits

  • โœ“Access to new treatment approaches before public availability
  • โœ“Close monitoring by experienced medical professionals
  • โœ“Study-related care provided at no cost
  • โœ“Contribute to medical research for Knee Osteoarthritis

What to Expect

  • โ†’Initial screening to determine eligibility
  • โ†’Regular check-ups and monitoring visits
  • โ†’Possible compensation for time and travel
  • โ†’You can withdraw at any time

Frequently Asked Questions About This Knee Osteoarthritis Study

Important Clinical Trial Information

This information is provided for educational purposes and does not constitute medical advice. Clinical trial participation involves potential risks and benefits. Eligibility requirements apply and will be assessed during the screening process.

Study identifier: NCT06884865. For complete study details, visit ClinicalTrials.gov. Always consult with your healthcare provider before making decisions about your medical care or participating in clinical research.