Is NCT07392450 recruiting in Scottsdale, AZ?

Yes, NCT07392450 is currently recruiting participants at its Scottsdale, AZ location. This acute ischemic stroke clinical trial is actively enrolling qualified participants.

How do I join the acute ischemic stroke clinical trial in Scottsdale?

To join this clinical trial in Scottsdale, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Scottsdale clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Acute Ischemic Stroke Clinical Trial in Scottsdale, AZ

About This Acute Ischemic Stroke Study in Scottsdale

Acute ischemic stroke (AIS) is a medical emergency that happens because of a sudden stop of blood flow to a part of the brain. This happens when a blood clot forms within the vessel (known as thrombotic occlusion) or a clot originating from somewhere else blocks a blood vessel (known as embolic occlusion). Strokes can cause serious health problems, death, and affect one's quality of life. To reduce long-term damage, it is important to restore blood flow to the brain as soon as possible. The main aim of this study is to check how safe TAK-755 is, and how well adults with AIS tolerate it. Other aims are to check how well TAK-755 helps participants to manage their everyday activities and to understand whether it helps reduce the seriousness of their stroke symptoms when compared to placebo. A placebo looks like TAK-755, but does not have any medicine in it, to make sure participants do not know which treatment they are taking. The participants will receive TAK-755 or placebo once; afterwards, their health will be monitored for about 3 months (90 days). All participants, regardless of their assignment to either TAK-755 or placebo, will receive the usual treatment for AIS as per the hospital's normal practice.

Sponsor: Takeda

Who Can Participate

Inclusion Criteria

Informed Consent:

The participant or legally authorized representative has provided informed consent before the initiation of any trial procedures. Age:

18 to 80 years of age, inclusive, at the time of signing the informed consent form. Clinical Characteristics:

Clinical diagnosis of AIS.

Onset of stroke symptoms within 24 hours of enrollment. Wake-up strokes may be included if Last Known Well is within 24 hours of enrollment; time of onset will be considered the time of Last Known Well.

National Institutes of Health Stroke Scale score of 6 to 25, indicating moderate to severe stroke.

Estimated Modified Rankin Scale score less than (\<) 2 prior to AIS presentation, signifying no significant disability.

Signs and symptoms consistent with anterior circulation stroke. Imaging:

Evidence of causative AIS occlusion on imaging (intracranial internal carotid artery \[ICA\], M1, M2, M3, M4, A1, A2, A3).

Evidence of salvageable brain tissue on CT or MR imaging.

Exclusion Criteria

Medical History:

Weight \>130 kilograms (kg) or \<40 kg.

History of severe traumatic brain injury in the past 90 days.

History of intracranial hemorrhage.

History of intracranial neoplasm except for small meningioma.

History of prior stroke in the past 90 days.

History of intracranial or intraspinal surgery within the past 90 days.

Major surgery or severe trauma in the past 14 days.

History of cerebral amyloid angiopathy.

History of systemic malignancy, except for locally excised basal cell or squamous cell skin carcinoma with clear margins.

Diagnosis of serious, advanced, or terminal illness with anticipated life expectancy of less than 1 year.

Participation in other interventional clinical trials within the previous 90 days.

Known life-threatening hypersensitivity reaction to TAK-755 or its components.

Any prior administration of TAK-755.

Administration of caplacizumab in the past 30 days.

Administration of von Willebrand factor-containing products in the past 14 days.

Baseline conditions (prior to the index AIS event) that prevent an understanding of the nature, scope, and possible consequences of the trial, in the judgment of the investigator. Current Stroke Management:

Any prior administration (intravenous or intra-arterial) of alteplase or tenecteplase for the index AIS event, as well as any prior administration of prourokinase or reteplase for the index AIS event in countries where approved.

Eligible for administration of intravenous thrombolysis (alteplase or tenecteplase, as well as prourokinase or reteplase in countries where approved) for the index AIS event, based on the site's standard clinical guidelines and direct availability.

Intent to proceed with endovascular thrombectomy (EVT) for the index AIS event based on eligibility and direct availability.

Seizure at time of index AIS event onset.

Persistent blood pressure elevation (systolic \>=185 millimeters of mercury \[mmHg\] or diastolic \>=110 mm Hg) prior to randomization.

Blood glucose \<50 milligrams per deciliter (mg/dL) or \>400 mg/dL. Current Medical Conditions:

Active, uncontrolled bleeding.

Bleeding diathesis or any other conditions that would pose significant bleeding risk.

Inability to undergo MRI or CT.

Rapidly improving AIS symptoms.

Chronic causative intracranial occlusion.

Causative total occlusion of the extracranial ICA.

Evidence of septic emboli or bacterial endocarditis.

Another clinically significant concomitant disease that may pose additional risks for the participant in the opinion of the investigator.

Pregnancy, lactation, or unable to comply with birth control methods or abstinence as specified in the protocol in the opinion of the investigator. Imaging:

Poor quality imaging that precludes interpretation according to trial protocol.

Evidence of significant intracranial mass effect or midline shift.

Evidence of occlusion in \>1 vascular territory.

Evidence of acute or chronic intracranial hemorrhage.

Evidence of extensive early ischemic change estimated to be greater than one-third of the middle cerebral artery territory.

Evidence of intracranial tumor (except incidental, small meningioma), cerebral aneurysm, or arteriovenous malformation. Laboratory:

Platelet count \<50,000/ cubic millimeters (mm\^3). Other:

Identification by the investigator as being potentially unable or unwilling to cooperate with trial procedures.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Scottsdale?

Yes, this clinical trial (NCT07392450) has an active research site in Scottsdale, AZ that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Acute Ischemic Stroke Treatment Options in Scottsdale, AZ

If you're searching for acute ischemic stroke treatment options in Scottsdale, AZ, this clinical trial (NCT07392450) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Scottsdale research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced acute ischemic stroke specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all acute ischemic stroke clinical trials near you to find additional studies recruiting in your area.

Acute Ischemic Stroke Clinical Trial in Scottsdale, AZ

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