Los Angeles, CANCT05758077Now EnrollingIRB Ready

Acute Kidney Injury Clinical Trial in Los Angeles, CA

Access cutting-edge acute kidney injury treatment through this clinical trial at a research site in Los Angeles. Study-provided care at no cost to qualified participants.

Sponsored by SeaStar Medical

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Expert Care in Los Angeles

Access acute kidney injury specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related acute kidney injury treatment provided free

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Check if you qualify for this acute kidney injury clinical trial in Los Angeles, CA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Los Angeles

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Los Angeles site if eligible
  4. 4Begin participation

About This Acute Kidney Injury Study in Los Angeles

This randomized, controlled, pivotal study is intended to determine whether up to ten sequential 24-hour treatments with the Selective Cytopheretic Device (SCD) will improve survival in patients with Acute Kidney Injury (AKI) requiring continuous kidney replacement therapy (CKRT) when compared to CKRT alone (standard of care). This study is further intended to determine whether SCD therapy will reduce the duration of maintenance dialysis secondary to AKI. This study will enroll approximately 339 subjects across 30 US sites. Participants will be patients in an intensive care unit (ICU) setting with a diagnosis of AKI requiring CKRT.

Sponsor: SeaStar Medical

Who Can Participate

Inclusion Criteria

Admitted to an ICU requiring CKRT:
Must have AKI stage 2 or greater at the time of CKRT initiation.
Must have been on CKRT for at least 12 hours but no greater than 48 hours at the time of enrollment.
At least 18 years of age but not older than 80 at the time of enrollment.
One additional life-threatening organ dysfunction present.
Acceptable vascular access for CKRT to include adequate lumen size and length of catheters.
Initial (non-binding) commitment to maintaining current level of care for at least 96 hours.
C-Reactive Protein \>3.5 mg/dl.

Exclusion Criteria

Not expected to survive next 24 hours.
Anticipated transition to comfort measures or hospice in next 4 days.
Terminal condition whereby the patient is not expected to survive 28 days or any condition in which therapy is regarded as futile by the PI.
Advanced malignancy which is actively being treated or may be treated with palliative chemotherapy or radiation.
ICU hospitalization \> 14 days during this hospital admission (to include days spent at ICU of an outside hospital) at the time of screening.
Active COVID-19 infection with a primary admission diagnosis of COVID-19.
Chronic use of ventricular assist devices.
ESRD requiring chronic kidney replacement therapy.
History of CKD (greater than Stage 3).
AKI stage 0 or stage 1 at the time of CKRT initiation.
Non-ATN AKI diagnosis. We intend on relying on local nephrology subspecialty expertise to reasonably exclude non-ATN diagnoses based on clinical suspicions combined with prespecified objective criteria. If there is a reasonable suspicion that the subject has non-ATN AKI based on this, they will be excluded from the trial.
Acute coronary syndromes, acute stroke, or acute major vascular compromise requiring medical or surgical interventions within 48 hours of randomization.
Active hemorrhage requiring blood transfusions at the time of screening.
Acute on Chronic Liver Failure.
Suspicion of hepato-renal syndrome.
Presence of any solid organ transplant at any time prior to admission.
Severe burns with a modified Baux score \> 100 (%TBSA+Age+17 for Inhalation Injury).
Bone marrow transplant within the last year.
Chronic immunosuppression with an average of \>20 mg/day of prednisone or other steroid sparing immunosuppressants for the past 30 days prior to hospital admission.
Individuals who have a history of primary or secondary immune disorders including, but not limited to, HIV or AIDS.
Dry weight of \>150kg.
Platelet count \<15,000/mm3.
Patient is a prisoner or member of a vulnerable population.
Patient is pregnant or breast feeding.
Concurrent enrollment in another interventional clinical trial for an investigational drug or device.
Need for plasmapheresis.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Los Angeles?

Yes, this clinical trial (NCT05758077) has an active research site in Los Angeles, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Acute Kidney Injury Treatment Options in Los Angeles, CA

If you're searching for acute kidney injury treatment options in Los Angeles, CA, this clinical trial (NCT05758077) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Los Angeles research site is actively enrolling participants for this clinical trial. You'll receive care from experienced acute kidney injury specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

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Secure · Expert Care · Los Angeles, CA