Is NCT05884333 recruiting in New York, NY?

Yes, NCT05884333 is currently recruiting participants at its New York, NY location. This acute myelogenous leukemia (aml) clinical trial is actively enrolling qualified participants.

How do I join the acute myelogenous leukemia (aml) clinical trial in New York?

To join this clinical trial in New York, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this New York clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Acute Myelogenous Leukemia (AML) Clinical Trial in New York, NY

About This Acute Myelogenous Leukemia (AML) Study in New York

Cord blood transplants (CBT) are a standard treatment for adults with blood cancers. MSK has developed a standard ("optimized") practice for cord blood transplant (CBT). This optimized practice includes how patients are evaluated for transplant, the conditioning treatment (standard chemotherapy and total body irradiation therapy) given to prepare the body for transplant, the amount of stem cells transplanted, and how patients are followed during and after transplant.The purpose of this study is to collect information about participant outcomes after CBT following MSK's optimized practice. The researchers will look at outcomes of the CBT treatment such as side effects, disease relapse, GVHD, and immune system recovery after CBT treatment.

Sponsor: Memorial Sloan Kettering Cancer Center

Who Can Participate

Inclusion Criteria

I. Acute myelogenous leukemia (AML):

Complete first remission (CR1) at high risk for relapse such as any of the following:

Known prior diagnosis of myelodysplasia (MDS) or myeloproliferative disorder (MPD).

Therapy-related AML.

Presence of extramedullary leukemia at diagnosis.

Requirement for 2 or more inductions to achieve CR1.

Intermediate or high ELN2017 genetic risk AML.

Any patient unable to tolerate consolidation chemotherapy as would have been deemed appropriate by the treating physician.

Other high-risk features not defined above.

Complete second remission (CR2) or greater (CR2+).

Patients in morphologic remission with persistent cytogenetic, flow cytometric, or molecular aberrations are eligible II. Acute lymphoblastic leukemia (ALL):

Complete first remission (CR1) at high risk for relapse such as any of the following:

Presence of any high-risk cytogenetic abnormalities such as t(9;22), t(1;19), t(4;11) or other MLL rearrangements (11q23) or other high-risk molecular abnormality.

Failure to achieve MRD- complete remission after induction therapy.

Persistence or recurrence of minimal residual disease on therapy.

Any patient unable to tolerate consolidation and/or maintenance chemotherapy as would have been deemed appropriate by the treating physician.

Other high-risk features not defined above.

Complete second remission (CR2) or greater (CR2+). Note: ALL with less than 5% blasts at time of transplant but persistent cytogenetic, flow cytometric or molecular aberrations are eligible. III. Other acute leukemias: Acute leukemias of ambiguous lineage or mixed phenotype with less than 5% blasts. Leukemias in morphologic remission with persistent cytogenetic, flow cytometric or molecular aberrations are eligible. IV. Myelodysplastic Syndromes (MDS) and Myeloproliferative Disorders (MPD) other than myelofibrosis:

International prognostic scoring system (IPSS) risk score of INT-2 or high risk at the time of diagnosis.

Any IPSS risk category if life-threatening cytopenia(s) exists.

Any IPSS risk category with karyotype or genomic changes that indicate high risk for progression to acute myelogenous leukemia.

MDS/MPD overlap syndromes without myelofibrosis.

MDS/ MPD patients must have less than 10% bone marrow myeloblasts and ANC \> 0.2 (growth factor supported if necessary) at transplant work-up. V. Non-Hodgkin lymphoma (NHL) at high-risk of relapse or progression if not in remission: Eligible patients with aggressive histologies (such as, but not limited to, diffuse large B-cell NHL, mantle cell NHL, and T-cell histologies) in CR by PET/CT imaging. o Eligible patients with indolent B-cell NHL (such as, but not limited to, follicular, small cell or marginal zone NHL) will have 2 nd or subsequent progression with PR or CR by PET/CT imaging. VI. Blastic plasmacytoid dendritic cell neoplasm (BPDCN) in morphologic remission. Organ Function and Performance Status Criteria:

Karnofsky score equal or greater than 80% (See Appendix B; inpatient Leukemia service transfers without discharge are acceptable provided patient has equivalent KPS as if were outpatient).

Calculated creatinine clearance \> 70 ml/min.

Bilirubin \< 1.5 mg/dL (unless benign congenital hyperbilirubinemia or hemolysis).

ALT \< 3 x upper limit of normal (ULN).

Pulmonary function: Spirometry (FVC and FEV1) and corrected DLCO) \> 60% predicted.

Left ventricular ejection fraction (MOD-bp)\> 50%.

Albumin \> 3.0.

Hematopoietic Cell Transplantation Comorbidity index (HCT-CI) ≤5. Graft criteria: Two CB units will be selected according to current MSKCC CB unit selection algorithm. High resolution 8-allele HLA typing and recipient HLA antibody profile will be performed. Unit selection will occur based on HLA-match, total nucleated cell (TNC) and CD34+ cell dose adjusted per patient body weight. The bank of origin will also be considered. Donor specific HLA antibodies, if present, will also be taken into consideration and may influence the selection of the graft.

Each CB unit must be at least 3/8 HLA-matched to the patient considering high-resolution 8-allele HLA typing. \[Taken from the Cord Blood Summary\]

Each CB unit will be required to have a cryopreserved TNC dose of at least 1.5 x 10\^7 TNC/ recipient body weight (TNC/ kg). \[Taken from the Cord Blood Summary\]

Each CB unit will be required to have a cryopreserved CD34+ cell dose of at least 1.5 x 10\^5 CD34+ cells/ recipient body weight (CD34+ cells/kg). \[Taken from the Cord Blood Summary\]

A minimum of one unit will be reserved as a backup graft. \[Taken from the Cord Blood Summary\]

Each CB unit will be required to be cryopreserved in standard cryovolume (24-27 ml/s per unit or per bag if unit in two bags) and be red blood cell depleted. \[Taken from the Cord Blood Summary\]

Exclusion Criteria

Diagnosis of myelofibrosis or other malignancy with moderate-severe bone marrow fibrosis.

Patients with persistent with CNS involvement in CSF or CNS disease at time of screening

Prior checkpoint inhibitors/ blockade in the last 12 months.

Two prior stem cell transplants of any kind.

One prior autologous stem cell transplant within the preceding 12 months.

Prior allogeneic transplantation.

Prior involved field radiation therapy that would preclude safe delivery of 400cGy TBI in the opinion of Radiation Oncology.

Active and uncontrolled infection at time of transplantation.

HIV infection.

Seropositivity for HTLV-1.

Inadequate performance status/ organ function.

Pregnancy or breast feeding.

Patient or guardian unable to give informed consent or unable to comply with the treatment protocol including appropriate supportive care, long-term follow-up, and research tests.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New York?

Yes, this clinical trial (NCT05884333) has an active research site in New York, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Acute Myelogenous Leukemia (AML) Treatment Options in New York, NY

If you're searching for acute myelogenous leukemia (aml) treatment options in New York, NY, this clinical trial (NCT05884333) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New York research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced acute myelogenous leukemia (aml) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all acute myelogenous leukemia (aml) clinical trials near you to find additional studies recruiting in your area.

Acute Myelogenous Leukemia (AML) Clinical Trial in New York, NY

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