Is NCT07549477 recruiting in Middletown, NJ?

Yes, NCT07549477 is currently recruiting participants at its Middletown, NJ location. This adult cancer patients clinical trial is actively enrolling qualified participants.

How do I join the adult cancer patients clinical trial in Middletown?

To join this clinical trial in Middletown, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Middletown clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Adult Cancer Patients Clinical Trial in Middletown, NJ

About This Adult Cancer Patients Study in Middletown

The researchers are doing this study to see how well cardiac magnetic resonance imaging (CMR) scans can be used to examine the properties of central venous catheter-associated right atrial clot (RA clot). This could help doctors decide on the best treatment options.

Sponsor: Memorial Sloan Kettering Cancer Center

Who Can Participate

Inclusion Criteria

Documentation of Disease o Patients must have pathologically confirmed systemic cancer of any types and stages (solid tumors or hematologic malignancies) at the time of CMR which will be used to evaluate the presence or absence of cardiac mass and additional tissue characterization for confirmation of RATHR.

Definition of Disease \[or Measurable Disease\]

Cardiac mass (CMASS) will be initially localized on cine-CMR, on which it is defined via established criteria as a discrete tissue prominence independent from normal anatomic structures, quantified based on size (area, cross-sectional linear dimensions)

CMASS will be further categorized by type (CNEO or CTHR) based on CMR tissue characterization: CNEO and CTHR can be differentiated based on presence of contrast enhancement via the reference standard of LGE-CMR using established criteria previously validated by our group and others.

CTHR is defined as discrete mass(es) with avascular tissue properties (enhancement absent).

CTHR will be further subgrouped into RATHR after confirmation of its location and in relation to CVC.

CNEO is defined as discrete mass(es) with vascular tissue properties (enhancement present),

CNEO can be further sub-typed based on visually scored magnitude of enhancement (diffusely hyper-enhancing, mixed, predominantly hypo-enhancing) in accordance with established methods previously used by our group.

Required Organ Function: o Adequate renal function defined as follows:

Creatinine clearance (CrCL) of ≥30 mL/min by the Cockcroft-Gault formula (Note: For agents for which renal excretion is not a major route of clearance and for which renal toxicity is not an issue, the threshold for creatinine clearance should be ≥30 mL/min.): CrCl (mL/min) = \[140 - age (years)\] x weight (kg) 72 \

creatinine (mg / dL)

No history of allergic reaction to the gadolinium contrast agent or compounds of similar chemical or biologic composition

Subjects in RATHR+ group must meet the following criteria:

Adult cancer patients (stage I-IV) who are greater than 18 years of age

Presence of indwelling central venous catheter (Mediport, PICC, Hickman, pheresis cath, etc) with a minimal duration of 7 days prior to CMR

Presence of RATHR based on established CMR criteria (i.e. absence of enhancement on LGE-CMR)

Patients who underwent CMR within the past 3 months for evaluation of cardiac masses are eligible if confirmed for the presence of RATHR

Exclusion Criteria

Known pre-existing CV disease which can affect hemodynamics within cardiac chambers as determined by the investigator, including

Arrhythmia - chronic persistent atrial arrhythmias

Cardiomyopathies including Ischemic or non-ischemic cardiomyopathy with LVEF \<53%

Restrictive cardiomyopathy - cardiac amyloidosis, myocardial fibrosis

Constrictive pericarditis

Valvular heart disease with equal to or greater than moderate stenosis or regurgitation

Cardiac neoplastic involvement

Subjects will be excluded if they are unable to provide informed consent due to underlying clinical conditions and mental status.

Subjects will be excluded for getting CMR if they are

Subjects who would be normally excluded from undergoing a MRI examination as per institutional standard of care. At MSK, patients will be screened by radiology technicians using Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire (Appendix 1) prior to getting cardiac MRI

Subjects with presence of MRI incompatible metal fragments, aneurysm clip, implants or devices that would warrant avoidance of a strong magnetic field

Contraindications to receive gadolinium contrast

Renal dysfunction (GFR \<30 mL/min) or end stage renal disease

Prior allergic reaction to gadolinium

Subject who are unable to tolerate CMR due to clinical status, respiratory compromise, or severe claustrophobia

Female participants who are pregnant or nursing

Subjects defined as vulnerable populations, as defined by 45 CFR 46

Participants at higher risk due to age, frailty, or the emergent nature of their condition

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Middletown?

Yes, this clinical trial (NCT07549477) has an active research site in Middletown, NJ that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Adult Cancer Patients Treatment Options in Middletown, NJ

If you're searching for adult cancer patients treatment options in Middletown, NJ, this clinical trial (NCT07549477) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Middletown research site is actively enrolling participants for this clinical trial. You'll receive care from experienced adult cancer patients specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all adult cancer patients clinical trials near you to find additional studies recruiting in your area.

Adult Cancer Patients Clinical Trial in Middletown, NJ

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