NCT06963723 · Alliance Foundation Trials, LLC.
Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer
(PROOF)
What this study is about
The study aims to determine whether monthly remote digital financial hardship screening among adults with advanced/metastatic cancer, undergoing outpatient systemic therapy with non-curative intent, improves patient-centered outcomes, including financial worry, health-related quality of life (HRQoL), symptom burden, patient-reported cancer treatment adherence, and exploratory outcomes of how long patients live, patient-reported economic burden, patient-reported support received, patient-reported financial coping strategies, and health insurance literacy.
View original scientific description
The study aims to determine whether monthly remote digital financial hardship screening among adults with advanced/metastatic cancer, undergoing outpatient systemic therapy with non-curative intent, improves patient-centered outcomes, including financial worry, health-related quality of life (HRQoL), symptom burden, patient-reported cancer treatment adherence, and exploratory outcomes of overall survival, patient-reported economic burden, patient-reported support received, patient-reported financial coping strategies, and health insurance literacy.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Minimum age of 21
- Understands English and/or Spanish
- Has a diagnosis of advanced/metastatic cancer
- Currently undergoing systemic therapy (enteral or parenteral) with non-curative intent
- Has been receiving treatment for at least 2 months
- Life expectancy of at least 6 months, in the opinion of the treating oncologist
- Cognitively able to give informed consent
Exclusion criteria
- Under the age of 21
- Does not understand English or Spanish
- Has cognitive deficits that would preclude understanding of consent form and/or questionnaires
- Undergoing treatment with curative intent (e.g., adjuvant chemotherapy for breast, lung, or ovarian cancer, primary curative therapy for testis cancer or lymphoma)
- Not undergoing systemic therapy (enteral or parenteral) with non-curative intent
- Receiving treatment for fewer than 2 months
- Life expectancy is less than 6 months, in the opinion of the treating oncologist
Where
- Phoenix, Arizona
- Concord, New Hampshire
- Manchester, New Hampshire
- New York, New York
- Fargo, North Dakota
- Spartanburg, South Carolina
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 12, 2026 · Source of record for eligibility and locations