Houston, TXNCT06270706Now EnrollingIRB Ready

Advanced or Metastatic Solid Tumor Clinical Trial in Houston, TX

Access cutting-edge advanced or metastatic solid tumor treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by Pliant Therapeutics, Inc.

Quick Self-Assessment

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Expert Care in Houston

Access advanced or metastatic solid tumor specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related advanced or metastatic solid tumor treatment provided free

Apply for This Houston Location

Check if you qualify for this advanced or metastatic solid tumor clinical trial in Houston, TX

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Advanced or Metastatic Solid Tumor Study in Houston

This is a Phase 1a/1b, dose-escalation/expansion, consecutive-cohort, open-label study to evaluate the safety, tolerability, PK, PD, and preliminary evidence of antitumor activity of PLN-101095 in combination with pembrolizumab (the study treatment regimen) in adult participants with advanced or metastatic solid tumors for which pembrolizumab is indicated but have documented disease progression (refractory \[primary resistance\]) or relapsed \[secondary resistance\]) after at least 3 months from the start of treatment with pembrolizumab. The study will consist of 2 main parts: * Part 1: Consecutive dose-escalation cohorts using a Bayesian optimal interval (BOIN) dose escalation design with accelerated titration * Part 2: Dose-expansion cohorts using Simon's 2-stage design

Sponsor: Pliant Therapeutics, Inc.

Who Can Participate

Inclusion Criteria

Has histologically or cytologically confirmed advanced or metastatic solid tumor
Have received ≥12 weeks of continuous anti-PD-1 or anti-PD-L1 treatment administered as monotherapy or in combination with other anticancer therapies
Have demonstrated documented prior clinical benefit, defined as CR or PR at any time during treatment, or SD lasting ≥6 months (Part 2 only)
Must have subsequently developed radiographic disease progression while receiving anti-PD-1 or anti-PD-L1 treatment or within ≤12 weeks after the last dose of such treatment
At least 1 measurable lesion, as defined by RECIST v1.1
Estimated survival of ≥3 months
Have adequate bone marrow and organ function.
A female participant is eligible to participate if she is not pregnant, not breastfeeding

Exclusion Criteria

Any immune-related medical conditions that would put participants at greater risk when receiving pembrolizumab
Has a known additional malignancy that is progressing or has required active treatment within the past 2 years
Has received prior radiotherapy within 2 weeks for palliative bone-directed therapy and 4 weeks for all other radiotherapy
Has undergone major surgery within 4 weeks prior to the first dose of study treatment or has not adequately recovered from surgery or related complications
Has a diagnosis of immunodeficiency or use of systemic steroids \>10 mg/day
Has an active autoimmune disease that has required systemic treatment in the past 2 years
Has known active CNS metastases (brain and/or leptomeningeal metastases)
Has significant cardiac disease
Has an active infection requiring systemic therapy (including uncontrolled HIV, Hepatitis B and C)
Has received a live or live-attenuated vaccine within 30 days or a non-live vaccine within 7 days prior to the first dose of PLN-101095

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT06270706) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Advanced or Metastatic Solid Tumor Treatment Options in Houston, TX

If you're searching for advanced or metastatic solid tumor treatment options in Houston, TX, this clinical trial (NCT06270706) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced advanced or metastatic solid tumor specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all advanced or metastatic solid tumor clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Houston, TX