Durham, NCNCT05665465Now EnrollingIRB Ready

Adverse Childhood Experiences Clinical Trial in Durham, NC

Access cutting-edge adverse childhood experiences treatment through this clinical trial at a research site in Durham. Study-provided care at no cost to qualified participants.

Sponsored by Duke University

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Expert Care in Durham

Access adverse childhood experiences specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related adverse childhood experiences treatment provided free

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Check if you qualify for this adverse childhood experiences clinical trial in Durham, NC

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Durham

    Convenient for NC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Durham site if eligible
  4. 4Begin participation

About This Adverse Childhood Experiences Study in Durham

The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults. The investigators assess responses to nicotine exposure by giving participants a small amount of nicotine or placebo, and then asking them to answer questionnaires. The investigational drugs used in this study are a nicotine nasal spray (i.e., Nicotrol) and/or a nasal spray placebo (made of common kitchen ingredients, including a very tiny amount of pepper extract also called capsaicin). The investigators assess brain function through function magnetic resonance imaging (fMRI), which is a noninvasive procedure that uses a magnetic field to take pictures of your brain while you are performing certain tasks. This study will help us to learn more about why some childhood experiences (adverse childhood experiences, or ACEs) contribute to increased risk for smoking and other substance use.

Sponsor: Duke University

Who Can Participate

Inclusion Criteria

generally healthy
18-21 years of age
never smoked a full cigarette or used an equivalent amount of other nicotine or tobacco products
no tobacco exposure in the past 3 years
expired air CO level ≤ 3 ppm
corroboration of non-smoking status from 2 collateral reporters
breath alcohol value = 0.000

Exclusion Criteria

use of illegal drugs as measured by urine drug screen
reported history of illicit drug use \> 10 times lifetime
lifetime history of alcohol use disorder
binge drinking \> 5 times per month over the past 3 months
history of serious mental illness including bipolar or psychotic disorders
significant medical or unstable psychiatric disorders
systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg
heart rate ≥ 100 bpm
use of psychoactive medications (e.g., antidepressants, opioid analgesics, etc.) in the past 6 months
presence of conditions that would make fMRI unsafe (e.g., pacemaker)
brain abnormality (including but not limited to stroke, brain tumor, and seizure disorder)
history of serious traumatic brain injury
claustrophobia
lack of firm resolve to refrain from cigarette, e-cigarette or other tobacco use in the coming year
pregnant, trying to become pregnant, or breastfeeding
inability to understand written and/or spoken English language
inability to attend all experimental sessions

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Durham?

Yes, this clinical trial (NCT05665465) has an active research site in Durham, NC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Adverse Childhood Experiences Treatment Options in Durham, NC

If you're searching for adverse childhood experiences treatment options in Durham, NC, this clinical trial (NCT05665465) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Durham research site is actively enrolling participants for this clinical trial. You'll receive care from experienced adverse childhood experiences specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all adverse childhood experiences clinical trials near you to find additional studies recruiting in your area.

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