Cleveland, OHNCT03224949Now EnrollingIRB Ready

ALD - Alcoholic Liver Disease Clinical Trial in Cleveland, OH

Access cutting-edge ald - alcoholic liver disease treatment through this clinical trial at a research site in Cleveland. Study-provided care at no cost to qualified participants.

Sponsored by The Cleveland Clinic

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Expert Care in Cleveland

Access ald - alcoholic liver disease specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related ald - alcoholic liver disease treatment provided free

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Check if you qualify for this ald - alcoholic liver disease clinical trial in Cleveland, OH

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Why Participate?

  • No-Cost Study Care

  • Local to Cleveland

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Cleveland site if eligible
  4. 4Begin participation

About This ALD - Alcoholic Liver Disease Study in Cleveland

The availability of biological samples from individuals with alcoholic liver disease (ALD), as well as samples from appropriate heavy drinking, yet healthy controls and non-drinking healthy controls, is an essential first step in the translation of basic research advances to the clinic. The purpose of the Clinical Core component of the P50 Northern Ohio Alcohol Center (NOAC) is to provide biological samples (plasma/serum, buffy coats, and urine) from patients with different stages of alcoholic liver disease, as well as healthy control subjects, to members of the NOAC. These samples can then be used to test specific hypotheses related to the presence of specific biomarkers in the serum, functional immune activity in PBMCs and/or genetic polymorphisms that may predict severity of disease, short- and long-term morbidity and mortality and/or responsivity to specific therapeutic interventions commonly used in clinical practice. This study is building on the established biorepositories and the diversity of outstanding clinical expertise at the Cleveland Clinic. This biorepository included clinical samples (plasma, serum, buffy coats, and urine) from patients with different stages of ALD and subjects who are heavy drinkers without ALD, recruited from the Cleveland Clinic alcohol use disorder treatment clinic. This study will be responsible for collecting more data to help build the CCF-ALD biorepository via subject recruitment and communication and specimen collection.

Sponsor: The Cleveland Clinic

Who Can Participate

Inclusion Criteria

Fat accumulation (Steatosis) without signs of fibrosis/ inflammation in patients with alcohol abuse (alcohol intake \>60 g/day in men and \>40 g/day in women)
Abnormal liver serum tests indicative of liver disease (elevated AST\>ALT, y-glutamyl transpeptidase and bilirubin) . Alcoholic Hepatitis with Mild Fibrosis Inclusion
Steatosis plus hepatocellular damage (presence of Mallory bodies and hepatocellular ballooning)
Polymorphonuclear infiltrate
Fibrosis stage 1-2 Alcoholic Hepatitis with Advanced Fibrosis Inclusion
Steatosis plus hepatocellular damage (presence of Mallory bodies and hepatocellular ballooning)
Polymorphonuclear infiltrate
Fibrosis stage 3-4. Alcoholic Cirrhosis Inclusion
Fibrosis stage 4
Presence of complications of cirrhosis such as esophageal varices with our without a previous episode of bleeding, splenomegaly, ascites, hepatic corroborate the diagnosis of cirrhosis. Alcoholic Cirrhosis with HCC Inclusion -Diagnostic criteria of cirrhosis and established HCC. The diagnosis of HCC will be established based on histological confirmation or contrast-enhanced radiographic imaging according to the AASLD recommendations.

Exclusion Criteria

Hemochromatosis
Wilson's disease
Autoimmune hepatitis
Drug-inducted liver disease
Hepatitis C
Antitrypsin deficiency
Patients who do not sign informed consent. Non-alcoholic steatohepatitis Inclusion -Biopsy proven NASH and chronic liver disease due to HCV patients. Exclusion
Hypertension
CAD or stroke
Past history of liver disease
Hepatitis C
Antitrypsin deficiency
Alcohol consumption of less than 7 drinks per week for women and less than 14 drinks per week for men
BMI \>35. Healthy controls Inclusion -AUDIT-C score less than 4 in men and less than 3 in women. Exclusion
Cancer (except of non-melanoma skin cancer)
Hypertension
Hypercholesterolemia
Coronary artery disease or stroke
History of current or past liver disease of any etiology
BMI \>27Kg/m2

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Cleveland?

Yes, this clinical trial (NCT03224949) has an active research site in Cleveland, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

ALD - Alcoholic Liver Disease Treatment Options in Cleveland, OH

If you're searching for ald - alcoholic liver disease treatment options in Cleveland, OH, this clinical trial (NCT03224949) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Cleveland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced ald - alcoholic liver disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all ald - alcoholic liver disease clinical trials near you to find additional studies recruiting in your area.

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