Winter Park, FLNCT07693140Now EnrollingIRB Ready

Alzheimer Dementia Clinical Trial in Winter Park, FL

Access cutting-edge alzheimer dementia treatment through this clinical trial at a research site in Winter Park. Study-provided care at no cost to qualified participants.

Sponsored by Evan Thomas

Quick Self-Assessment

See if you qualify for this Winter Park location

Preparing your pre-screening questions…

Expert Care in Winter Park

Access alzheimer dementia specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related alzheimer dementia treatment provided free

Apply for This Winter Park Location

Check if you qualify for this alzheimer dementia clinical trial in Winter Park, FL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Winter Park

    Convenient for FL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Winter Park site if eligible
  4. 4Begin participation

About This Alzheimer Dementia Study in Winter Park

To evaluate the safety and tolerability of low-dose whole brain radiotherapy (WBRT) delivered as an induction course of 0.3 Gy × 10 fractions (3.0 Gy total) followed by 12 months of monthly maintenance LDRT (0.3 Gy × 10 fractions; 3.0 Gy total) in patients with Alzheimer's disease or dementia with inflammatory components

Sponsor: Evan Thomas

Who Can Participate

Inclusion Criteria

Age ≥50 years at time of enrollment
Externally confirmed diagnosis by a neurologist or geriatric psychiatrist (at Renaissance Institute, collaborating neurologist Dr. Sherif Makar, MD of Charis Neurology is available for diagnostic consultation) of one of the following: a. Alzheimer's disease (per NIA-AA 2011 or 2018 criteria) b. Frontotemporal dementia with documented inflammatory features c. Dementia with Lewy bodies with elevated inflammatory CSF markers d. Other neurodegenerative dementia with confirmed inflammatory component (elevated CSF IL-6, IL-1β, or TNF-α; or neuroimaging evidence of neuroinflammation)
MoCA score 10-25 at baseline screening (moderate-to-mild cognitive impairment range)
Karnofsky Performance Status (KPS) ≥60 or ECOG Performance Status ≤2
Medically stable and capable of receiving radiation therapy as assessed by the treating radiation oncologist
Reliable caregiver or informant able to accompany the patient to ≥80% of scheduled visits
Written informed consent from patient (if decision-making capacity is preserved) and/or legally authorized representative (LAR); caregiver co-consent required
Life expectancy ≥18 months in the opinion of the treating physician
Ability and willingness to comply with monthly clinic visits for the 12-month maintenance period \--------------------------------------------------------------------------------------

Exclusion Criteria

Prior whole brain or partial brain radiotherapy of any dose at any time
Active systemic malignancy requiring concurrent oncologic treatment
Implanted device contraindicated with radiation therapy (pacemaker, cochlear implant, deep brain stimulator, or equivalent)
Brain MRI demonstrating any of the following: (a) more than 4 cerebral microhemorrhages on susceptibility-weighted imaging (SWI) or gradient echo (GRE) sequences; (b) more than 1 area of superficial cortical siderosis; (c) severe white matter disease (Fazekas grade 3); or (d) any macrohemorrhage or hemosiderin-stained lesion \>10 mm. These thresholds are adapted from established AD trial imaging exclusion criteria to minimize enrollment of patients with advanced cerebrovascular disease or pre-existing hemorrhagic risk factors.
Known active cerebral amyloid angiopathy-related inflammation (CAA-ri) or amyloid-related beta-angiitis (ABRA), whether confirmed by biopsy, CSF analysis, or neuroimaging features consistent with active leptomeningeal or parenchymal amyloid-related inflammation
Active autoimmune encephalitis in acute phase (patients in stable chronic phase are eligible)
Uncontrolled systemic infection or active sepsis at enrollment
Severe psychiatric comorbidity (active psychosis, active suicidal ideation) impairing protocol compliance or safety assessment
Concurrent enrollment in another interventional trial targeting cognitive decline or neuroinflammation
Pregnancy or lactation; women of childbearing potential must use adequate contraception
Inability to lie flat and still for radiation delivery (approximately 10-15 minutes per session)
MoCA \<10 at baseline screening (severe dementia; insufficient cognitive range for endpoint assessment)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Winter Park?

Yes, this clinical trial (NCT07693140) has an active research site in Winter Park, FL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alzheimer Dementia Treatment Options in Winter Park, FL

If you're searching for alzheimer dementia treatment options in Winter Park, FL, this clinical trial (NCT07693140) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Winter Park research site is actively enrolling participants for this clinical trial. You'll receive care from experienced alzheimer dementia specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alzheimer dementia clinical trials near you to find additional studies recruiting in your area.

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