Belmont, MANCT05245903Now EnrollingIRB Ready

Alzheimer Disease Clinical Trial in Belmont, MA

Access cutting-edge alzheimer disease treatment through this clinical trial at a research site in Belmont. Study-provided care at no cost to qualified participants.

Sponsored by Mclean Hospital

Quick Self-Assessment

See if you qualify for this Belmont location

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Expert Care in Belmont

Access alzheimer disease specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related alzheimer disease treatment provided free

Apply for This Belmont Location

Check if you qualify for this alzheimer disease clinical trial in Belmont, MA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Belmont

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Belmont site if eligible
  4. 4Begin participation

About This Alzheimer Disease Study in Belmont

This project's main goal is to use state-of-the-art passive sensing techniques to identify digital biomarkers that relate to bioenergetic changes in the brain due to nicotinamide riboside supplementation in those with mild cognitive impairment and mild Alzheimer's dementia.

Sponsor: Mclean Hospital

Who Can Participate

Inclusion Criteria

Ability of the participant and/or his/her legally authorized representative to understand the purpose and risks of the study, to provide signed and dated informed consent, and to authorize the use of confidential health information.
Ability to speak and read fluently in English
18-89 years old (inclusive)
Normal or corrected to normal hearing and vision
Meet clinical diagnostic criteria for MCI or Mild AD, according to the criteria outlined above
Study partner available for duration of trial participation
At least one copy of the APOE ε4 allele
An aggregate risk score \> 4 according to the risk analysis method developed by Sabbagh et al. (2017)
For individuals who are taking niacin (or a vitamin supplement with niacin) of \>200mg, the completion of a two-week wash-out period

Exclusion Criteria

Current serious or unstable medical or neurological condition that could affect cognitive functioning, as determined by study clinician
Clinically unstable mood or anxiety disorder within 6 months prior to screening, as determined by study clinician
Lifetime history of psychotic disorder (i.e. Schizophrenia, Schizoaffective Disorder), as determined by study clinician
Diagnosis of a mitochondrial disorder
Any MRI safety contraindications
History of drug hypersensitivity or intolerance to NR
Transient ischemic attack or stroke within 1 year prior to screening
History of alcohol or substance abuse within prior year, as determined by study clinician and urine toxicology screen
History of head injury rated as moderate or worse, per DSM-5 criteria
History of seizure within prior 10 years
Current use of medication with known adverse effects on cognition (benzodiazepines, barbiturates, opiate analgesics, first generation antipsychotic medication, anticholinergics, sedating antihistamines, tricyclic anti-depressants)
Change in dose of any psychiatric medications within 4 weeks of screening visit
Prior use of L-DOPA, any anti-Parkinsonian medication, or prior treatment with anti-amyloid immunotherapy
Current use of putative mitochondrial enhancers or antioxidants (e.g. carnitine, creatine, Co-Q10, N-acetyl cysteine, pramipexole)
Initiation of treatment or change in dosing of acetylcholinesterase inhibitors (AChEIs) and memantine within 4 weeks of screening
Prior use of prescription narcotics 4 weeks before screening
Female subjects who are pregnant or breastfeeding
The current use of niacin (or a vitamin supplement with niacin) \>200mg within the last two weeks prior to study visit

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Belmont?

Yes, this clinical trial (NCT05245903) has an active research site in Belmont, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alzheimer Disease Treatment Options in Belmont, MA

If you're searching for alzheimer disease treatment options in Belmont, MA, this clinical trial (NCT05245903) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Belmont research site is actively enrolling participants for this clinical trial. You'll receive care from experienced alzheimer disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alzheimer disease clinical trials near you to find additional studies recruiting in your area.

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