Houston, TXNCT05582200Now EnrollingIRB Ready

Alzheimer Disease Clinical Trial in Houston, TX

Access cutting-edge alzheimer disease treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by The Methodist Hospital Research Institute

Quick Self-Assessment

See if you qualify for this Houston location

Preparing your pre-screening questions…

Expert Care in Houston

Access alzheimer disease specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related alzheimer disease treatment provided free

Apply for This Houston Location

Check if you qualify for this alzheimer disease clinical trial in Houston, TX

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Alzheimer Disease Study in Houston

Inflammation occurs in many brain diseases including Alzheimer's disease. In Alzheimer's disease, an abnormal protein called amyloid starts accumulating decades before the start of forgetfulness. However, scientists have reported that inflammation but not amyloid is linked to forgetfulness and the topography of brain inflammation and tau buildup are closely correlated in patients with mild cognitive impairment due to Alzheimer's disease. New medications are under development to help healing and prevent permanent damage in the brain. To see if inflammation is improving or getting worse with these medications, investigators can watch inside of the brain using a special camera called positron emission tomography (PET). It is currently possible to watch inflammation in the brain by taking pictures of a molecule called translocator protein (TSPO). But the problem is that by imaging TSPO, investigators can catch changes in more than one kind of cells. The information is not specific to each cell type. Such vague information is not completely useful to monitor the effect of new medications for inflammation. This proposal attempts to develop a novel method to capture changes in each of two major players in inflammation, microglia and astrocytes. To do so, investigators will take selective pictures of one cell type by using a novel imaging agent for PET. Investigators will also take PET pictures of TSPO. Investigators will process these two kinds of PET pictures using advanced mathematical methods and extract specific information on microglia and astrocytes. Our novel method will be useful to monitor new therapies to treat inflammation in the brain.

Sponsor: The Methodist Hospital Research Institute

Who Can Participate

Inclusion Criteria

Individuals of either sex, 50-90 years of age.
Meeting research criteria for AD (McKhann, Knopman et al. 2011).
With a CDR (Morris 1993) score of 1-3.
Fluent in English or Spanish.
Have sufficient communication and comprehension ability to consent to the performance of the study or have a legally authorized representative.

Exclusion Criteria

Inability to undergo MRI or PET for any reason, including severe claustrophobia.
History of large stroke or brain trauma, multiple sclerosis or other brain disorder that, in the judgment of the PI may confound the study.
Pregnancy. In women in whom the possibility of pregnancy cannot be excluded, a pregnancy test must be performed on site the morning of any PET visit and a negative result together with a physician interview are required prior to the administration or any radiopharmaceutical.
Research radiation exposure greater than 50 mSv effective dose within 12 months including radiation exposure from this study. Healthy volunteers: Inclusion criteria:
Individuals of 18-90 years of age.
Negative amyloid accumulation determined by PET (only for the comparison with AD).
Fluent in English.
Have enough communication and comprehension ability to consent to the performance of the study. Exclusion criteria:
Inability to undergo MRI or PET for any reason, including severe claustrophobia.
Brain disorder, other than idiopathic headache.
Current primary Axis I or II psychiatric disorder.
Current use of psychotropic or anti-epileptic medication.
Substance abuse during the past two years.
Active cancer, metabolic encephalopathy, infection, cardiovascular disease.
Active hematological, renal, pulmonary, endocrine or hepatic disorders, except for treated thyroid disease.
Pregnancy. In women in whom the possibility of pregnancy cannot be excluded, a pregnancy test must be performed on site the morning of any PET visit and a negative result together with a physician interview are required prior to the administration or any radiopharmaceutical
Research radiation exposure greater than 50 mSv effective dose within 12 months including radiation exposure from this study.
Only for the subjects undergoing the blocked scan with selegiline: known contraindications to selegiline, including hypersensitivity to the drug and use of opioids, such as meperidine and some antidepressants such as bupropion.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT05582200) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alzheimer Disease Treatment Options in Houston, TX

If you're searching for alzheimer disease treatment options in Houston, TX, this clinical trial (NCT05582200) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced alzheimer disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alzheimer disease clinical trials near you to find additional studies recruiting in your area.

More Alzheimers Disease Trials in Houston, TX

See all alzheimers disease clinical trials recruiting in Houston — not just this study.

Browse Alzheimers Disease Trials in Houston →

Browse More Trials by Condition

Alzheimers Disease TrialsAnkylosing Spondylitis TrialsMyalgic Encephalomyelitis TrialsAll Conditions →

Ready to Join in Houston?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Houston, TX