Is NCT06597942 recruiting in Los Angeles, CA?

Yes, NCT06597942 is currently recruiting participants at its Los Angeles, CA location. This alzheimer&#39;s disease clinical trial is actively enrolling qualified participants.

How do I join the alzheimer&#39;s disease clinical trial in Los Angeles?

To join this clinical trial in Los Angeles, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Los Angeles clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Alzheimer&Amp;Amp;#39;s Disease Clinical Trial in Los Angeles, CA

About This Alzheimer&Amp;Amp;#39;s Disease Study in Los Angeles

The goal of this clinical trial is to learn if using deep repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus is feasible, tolerable, and potentially efficacious for memory in Probable Alzheimer's Dementia. Previous work studying rTMS in Alzheimer's is mixed, but recent work studying rTMS of the precuneus is encouraging for both its short-term and long-term effects. The main questions this study aims to answer are: * Is deep rTMS of the precuneus feasible and tolerable in Alzheimer's? * Are there signs of positive brain changes in response to deep rTMS? * Is deep rTMS potentially efficacious for memory in Alzheimer's? Researchers will compare active stimulation to placebo stimulation while obtaining memory testing and measurements of the brain (imaging, scalp electrode measurements, bloodwork) to see if active treatment works to treat mild-to-moderate probable Alzheimer's Dementia. Participants will: * Engage with memory testing, brain scans, and bloodwork during a comprehensive assessment * Visit the clinic 3 times for 12 consolidated rTMS sessions, followed by 4 once weekly maintenance sessions * Be offered a full open-label active treatment course after completing their treatment course if they are initially in the placebo group

Sponsor: University of California, Los Angeles

Who Can Participate

Inclusion Criteria

Age 60-100 at the start of the study

Established diagnosis of Alzheimer's Clinical Syndrome (which is also met through a diagnosis of Alzheimer's Dementia)

Agreement to participate in study and able to complete informed consent process

Have a caregiver/study partner who can accompany them to all study visits

Have a known alternate surrogate decision-maker (in case needed) who can accompany them to the informed consent visit (this person may be the study partner mentioned above)

Screening MMSE score of 18-26

Screening GDS score \&lt;6

Either 1) treated with memory-enhancing medication (cholinesterase inhibitor) for at least 2 months, 2) failed trial with no plan to re-trial, or 3) no trial planned during the course of the study for other reasons

No change in use of psychotropic medication for the treatment of depression, anxiety, ADHD, or psychosis for 2 weeks prior to the study

Exclusion Criteria

Participant and/or their surrogate are unwilling or unable to provide informed consent

Currently pregnant or potentially pregnant

Diagnosis of a dementia or cognitive disorder due to a cause other than Alzheimer's Disease

Diagnosis of severe Dementia (CDR \> 2.0) at the start of the study

History of substance use disorder currently not in sustained remission

Substance misuse within the past 6 months (excluding nicotine or caffeine)

History of stroke, traumatic brain injury with loss of consciousness, or other major neurologic disorder (e.g., epilepsy, Huntington's disease, Parkinson's disease)

History of seizure disorder or family history of seizure disorder in a first-degree relative

Poorly-controlled hypertension, cardiovascular disease, or cerebrovascular disease

History of any other major active medical, neurologic, or psychiatric illness affecting cognition (associated with cognitive impairment) or a participant's ability to safely and meaningfully participate in the study

Non-fluent in English (not native or functionally-native)

Contraindication to TMS or MRI including claustrophobia, MRI-incompatible or unknown metal in body (including facial tattoos with uknown or metallic inks), surgery within 60 days, certain implants (excluding dental fillings), or previous abnormal MRI results.

Has previous history of TMS treatment in the past (not TMS naïve)

Currently enrolled in a memory-enhancement study

Alteration in cognitive-enhancement medication dose within the past 2 months or active plans for dose alteration during the course of the study (previously unplanned changes that occur during the study will be examined on a case-by-case basis)

History of treatment with lecanemab, aducanumab, donanemab, or other monoclonal antibody treatment for Alzheimer's Disease (due to lack of knowledge surrounding the impacts of these treatments)

Currently or within the past 2 weeks taking any of the following classes of medication:

Anticholinergic (e.g., tolterodine, benztropine)

Sedating antihistamines (e.g., diphenhydramine)

any drug that has significant anticholinergic or antihistaminic side effects (e.g., tricyclic antidepressant medications, mirtazapine).

Benzodiazepines. While not a strict rule out, this will be decided on a case-by-case basis

Antiepileptic agents. While not a strict rule out, this will be decided on a case-by-case basis

Antipsychotic agents. While not a strict rule out, this will be decided on a case-by-case basis

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Los Angeles?

Yes, this clinical trial (NCT06597942) has an active research site in Los Angeles, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alzheimer&Amp;Amp;#39;s Disease Treatment Options in Los Angeles, CA

If you're searching for alzheimer&amp;#39;s disease treatment options in Los Angeles, CA, this clinical trial (NCT06597942) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Los Angeles research site is actively enrolling participants for this phase 1/2 clinical trial. You'll receive care from experienced alzheimer&amp;#39;s disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alzheimer&amp;#39;s disease clinical trials near you to find additional studies recruiting in your area.

Alzheimer&Amp;Amp;#39;s Disease Clinical Trial in Los Angeles, CA

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