San Francisco, CANCT07866768Now EnrollingIRB Ready

Alzheimer's Disease (AD) Clinical Trial in San Francisco, CA

Access cutting-edge alzheimer's disease (ad) treatment through this clinical trial at a research site in San Francisco. Study-provided care at no cost to qualified participants.

Sponsored by University of California, San Francisco

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Expert Care in San Francisco

Access alzheimer's disease (ad) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related alzheimer's disease (ad) treatment provided free

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Check if you qualify for this alzheimer's disease (ad) clinical trial in San Francisco, CA

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to San Francisco

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit San Francisco site if eligible
  4. 4Begin participation

About This Alzheimer's Disease (AD) Study in San Francisco

The goal of this clinical trial is to learn if a wearable ultrasound device, called ATTN201, is safe and easy to use. The study is for adults ages 65 and older who have mild cognitive impairment (MCI) and a buildup of a protein called amyloid in the brain. Amyloid buildup is an early sign of Alzheimer's disease. The ATTN201 device sends low-intensity sound waves to a deep area of the brain that helps control sleep. The aim is to boost deep-sleep brain waves. These brain waves may help the brain clear away waste, including amyloid. The main questions it aims to answer are: 1. What, if any, issues do participants have when using the ATTN201 device? 2. Can participants complete the full study schedule? Researchers will compare focused ultrasound to unfocused ultrasound. Unfocused ultrasound is a look-alike treatment. It feels and sounds the same but is not aimed at the brain target. The comparison will show if the focused treatment changes sleep brain waves, blood markers of Alzheimer's disease, or memory and thinking. Participants will: * Visit the study site for memory and thinking tests, blood draws, a health check, and MRI scans of the brain * Record their sleep at home for at least 5 days with a sleep diary, a watch-like sensor, and a headband that measures brain waves * Be assigned by chance to focused or unfocused ultrasound * Take part in 10 nap sessions over 2 weeks while wearing the device, at the study site or at home * Return for a final visit to repeat the first tests, and may return for an optional visit 3 months later

Sponsor: University of California, San Francisco

Who Can Participate

Inclusion Criteria

65+ years old, male or female
Amyloid positivity as assessed by either PET, CSF, or plasma.
Qualify for an MCI Diagnosis.
Study partner available for informant measures.
Willing and able to undergo a brain MRI.
If currently on AD or sleep medications, must be at the same stable dose(s) for at least 3 weeks prior to screening and throughout the course of the study, and must continue to be under the care of their treating neurologist through the duration of the study.
Be able and willing to wear an Attune device during treatments
Able to sign informed consent in accordance with local regulations.
Be able to speak, read, and understand the language of the trial staff and the informed consent form.
Possess the ability to respond verbally to questions, follow instructions, and complete study assessments.
Be able to adhere to the stimulation protocol and visit schedules.
Be medically stable at baseline/randomization as assessed by medical history and non-significant clinical results of safety labs and vital signs examination.

Exclusion Criteria

Early-onset Alzheimer's disease, as defined by a diagnosis occurring prior to age 65.
Clinically significant depression, as defined by a score of \>10 on the Geriatric Depression Scale
Moderate to severe untreated obstructive sleep apnea, as defined by an Apnea-Hypopnea Index (AHI) ≥ 15.
Has other medical or psychiatric symptoms or conditions that, in the opinion of the investigator, will interfere with study activities or confound interpretation of study results.
Is on medication which, in the opinion of the investigator, will confound study results.
Has a history of deep brain stimulation or ablative surgery
Has a history of substance abuse including alcohol use disorder in the past 6 months
Has a history of traumatic brain injury
Has any contraindications for completing a brain MRI scan. a. The subject's head must fit within the head coil.
Has an uncontrolled medical condition which may impact study results.
Is or has an immediate family member of staff directly involved with this trial.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Francisco?

Yes, this clinical trial (NCT07866768) has an active research site in San Francisco, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Alzheimer's Disease (AD) Treatment Options in San Francisco, CA

If you're searching for alzheimer's disease (ad) treatment options in San Francisco, CA, this clinical trial (NCT07866768) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Francisco research site is actively enrolling participants for this clinical trial. You'll receive care from experienced alzheimer's disease (ad) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all alzheimer's disease (ad) clinical trials near you to find additional studies recruiting in your area.

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