Lexington, MANCT07439042Now EnrollingIRB Ready

Anxiety Clinical Trial in Lexington, MA

Access cutting-edge anxiety treatment through this phase 4 clinical trial at a research site in Lexington. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

Quick Self-Assessment

See if you qualify for this Lexington location

Preparing your pre-screening questions…

Expert Care in Lexington

Access anxiety specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related anxiety treatment provided free

Apply for This Lexington Location

Check if you qualify for this anxiety clinical trial in Lexington, MA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Lexington

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Lexington site if eligible
  4. 4Begin participation

About This Anxiety Study in Lexington

The purpose of the study is to do a preliminary trial to determine if buspirone is effective, safe, and tolerable in autistic youth with anxiety.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

Age 7-17 years
Diagnosis of Autism Spectrum Disorder (ASD) confirmed by the study clinician using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and Social Communication Questionnaire (SCQ)
Diagnosis of social phobia, separation anxiety disorder, or generalized anxiety disorder of at least moderate severity based on the Anxiety and Related Disorders Interview Schedule (ADIS), 5-item Pediatric Anxiety Rating Scale (PARS) score ≥10, and Clinical Global Impression Severity subscale (CGI-S) ≥4
IQ ≥50 based on Stanford Binet, 5th Edition Abbreviated IQ test or the Kaufman Brief Intelligence Test, 2nd Edition (KBIT-2)
Stable medications for ≥30 days
English speaking
Ability to swallow buspirone capsules or liquid suspension

Exclusion Criteria

Known diagnosis of a genetic syndrome associated with ASD (e.g. Fragile X syndrome, Angelman syndrome) based on parent report
Known cardiac arrythmia based on parent report
Current primary diagnosis of bipolar disorder, psychosis, substance use disorder, posttraumatic stress disorder, eating disorder, or major depressive disorder in the opinion of the PI
Any past or present conditions that would make treatment with buspirone unsafe
Current use of any of the following psychotropic medications: SSRIs, SNRIs, mirtazapine, benzodiazepines, tricyclic antidepressants, monoamine oxidase inhibitors, mood stabilizers, or antipsychotics
Previous adequate trial of buspirone (≥20 mg/day for at least 4 weeks) or significant adverse effects
Aberrant Behavior Checklist Irritability subscale score (ABC-I) ≥18
Pregnancy or sexual activity without the use of an acceptable form of birth control in females of childbearing age
Acutely unstable medical/psychiatric condition (e.g. self-injury, suicidality) that would preclude study participation in the opinion of the PI
Inability to tolerate Bittium Faros device in the opinion of the parent or a known allergy to adhesives

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Lexington?

Yes, this clinical trial (NCT07439042) has an active research site in Lexington, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Anxiety Treatment Options in Lexington, MA

If you're searching for anxiety treatment options in Lexington, MA, this clinical trial (NCT07439042) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Lexington research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced anxiety specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all anxiety clinical trials near you to find additional studies recruiting in your area.

More Essential Tremor Trials in Lexington, MA

See all essential tremor clinical trials recruiting in Lexington — not just this study.

Browse Essential Tremor Trials in Lexington →

Browse More Trials by Condition

Essential Tremor TrialsAnxiety TrialsAll Conditions →

Ready to Join in Lexington?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Lexington, MA