Birmingham, ALNCT07001800Now EnrollingIRB Ready

Aortic Valve Stenosis Clinical Trial in Birmingham, AL

Access cutting-edge aortic valve stenosis treatment through this phase 2/3 clinical trial at a research site in Birmingham. Study-provided care at no cost to qualified participants.

Sponsored by Kardigan, Inc.

Quick Self-Assessment

See if you qualify for this Birmingham location

Preparing your pre-screening questions…

Expert Care in Birmingham

Access aortic valve stenosis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related aortic valve stenosis treatment provided free

Apply for This Birmingham Location

Check if you qualify for this aortic valve stenosis clinical trial in Birmingham, AL

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Birmingham

    Convenient for AL residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Birmingham site if eligible
  4. 4Begin participation

About This Aortic Valve Stenosis Study in Birmingham

The purpose of this study is to evaluate if ataciguat slows the progression of moderate calcific aortic valve stenosis in adults.

Sponsor: Kardigan, Inc.

Who Can Participate

Inclusion Criteria

Adult male or female at least 50 years of age
Has moderate CAVS as defined by:
An AVA of ≥1.0 cm2 to ≤1.50 cm2
An AVC score between \>300 to 1200 Agatston units (AU) for women and between \>300 to 2000 AU for men
Has a left ventricular ejection fraction (EF) of ≥45% at the time of Screening as determined by the echocardiography Imaging Core Laboratory
For participants in CPET sub-study in Part A and all participants in Part B: If on beta blockade, the dose must be stable for at least 90 days prior to the Screening Visit with no anticipated changes during the study Key

Exclusion Criteria

For participants in the CPET sub-study in Part A and all participants in Part B: Has any medical or physical condition that, in the Investigator's opinion, could lead to an inability to complete Protocol-required CPET procedures (eg, pulmonary disease, joint, leg, hip, back conditions that limit physical activity, or other absolute contraindications for CPET)
Anticipated or planned prior aortic valve replacement, repair, surgery, or intervention in the next 6 months
Has moderate, moderate-to-severe, or severe (Grade 2 or higher) mitral stenosis, mitral regurgitation, and/or aortic regurgitation
Has suspected or known congenital aortic valve disease including bicuspid aortic valve
New York Heart Association (NYHA) Class IV heart failure symptoms and/or requires continuous inotropes
Has history of hypertrophic, genetic/familial cardiomyopathy or cardiomyopathy related to amyloid or sarcoid
Has untreated obstructive coronary artery disease or anticipating coronary stenting surgery
Abnormal electrocardiogram (ECG) results or long-standing persistent or permanent atrial fibrillation

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Birmingham?

Yes, this clinical trial (NCT07001800) has an active research site in Birmingham, AL that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Aortic Valve Stenosis Treatment Options in Birmingham, AL

If you're searching for aortic valve stenosis treatment options in Birmingham, AL, this clinical trial (NCT07001800) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Birmingham research site is actively enrolling participants for this phase 2/3 clinical trial. You'll receive care from experienced aortic valve stenosis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all aortic valve stenosis clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Birmingham, AL